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Functional connectivity in multiple sclerosis after robotic rehabilitative treatment: A case report
RATIONALE: Multiple sclerosis (MS) is an inflammatory demyelinating disease of central nervous system and it is associated with an impaired motor function status. The efficacy of rehabilitation in promoting functional recovery and increasing quality of life in MS patients has been demonstrated. PATI...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831415/ https://www.ncbi.nlm.nih.gov/pubmed/31027053 http://dx.doi.org/10.1097/MD.0000000000015047 |
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author | Bonanno, Lilla Russo, Margherita Bramanti, Alessia Calabrò, Rocco Salvatore Marino, Silvia |
author_facet | Bonanno, Lilla Russo, Margherita Bramanti, Alessia Calabrò, Rocco Salvatore Marino, Silvia |
author_sort | Bonanno, Lilla |
collection | PubMed |
description | RATIONALE: Multiple sclerosis (MS) is an inflammatory demyelinating disease of central nervous system and it is associated with an impaired motor function status. The efficacy of rehabilitation in promoting functional recovery and increasing quality of life in MS patients has been demonstrated. PATIENT CONCERNS: A 47-year-old woman was diagnosed with relapsing-remitting multiple sclerosis (RRMS) in November 2014 because of left upper limb hypoesthesia and weakness with difficulty in hand manipulation skills (there was a 1-point Expanded Disability Status Scale (EDSS) progression, i.e., 2.5 vs 1.5). Magnetic resonance image (MRI) showed a new frontal right cortical high-signal-intensity lesion. DIAGNOSIS: Neurological and MRI examination were suggestive of MS diagnosis. INTERVENTIONS: Patient was treated with robotic rehabilitation and evaluated by a Glove Analyzer for fMRI system (GAF). Functional MRI (fMRI) was acquired before and at the end of rehabilitative treatment performed with robotic device (Armeo-power). OUTCOMES: At the end of the rehabilitation program, most of the behavioral parameters, GAF and fMRI evaluation, showed a significative improvement. Moreover, fMRI showed a significantly increased functional activation within the sensory-motor network in the active, motor task. LESSONS: Our findings suggest a possible restorative effect of robotics on brain networks. Moreover, we may argue that GAF may be a valuable tool in assessing functional recovery after upper limb rehabilitation, especially of associated to fMRI examination. |
format | Online Article Text |
id | pubmed-6831415 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-68314152019-11-19 Functional connectivity in multiple sclerosis after robotic rehabilitative treatment: A case report Bonanno, Lilla Russo, Margherita Bramanti, Alessia Calabrò, Rocco Salvatore Marino, Silvia Medicine (Baltimore) 5300 RATIONALE: Multiple sclerosis (MS) is an inflammatory demyelinating disease of central nervous system and it is associated with an impaired motor function status. The efficacy of rehabilitation in promoting functional recovery and increasing quality of life in MS patients has been demonstrated. PATIENT CONCERNS: A 47-year-old woman was diagnosed with relapsing-remitting multiple sclerosis (RRMS) in November 2014 because of left upper limb hypoesthesia and weakness with difficulty in hand manipulation skills (there was a 1-point Expanded Disability Status Scale (EDSS) progression, i.e., 2.5 vs 1.5). Magnetic resonance image (MRI) showed a new frontal right cortical high-signal-intensity lesion. DIAGNOSIS: Neurological and MRI examination were suggestive of MS diagnosis. INTERVENTIONS: Patient was treated with robotic rehabilitation and evaluated by a Glove Analyzer for fMRI system (GAF). Functional MRI (fMRI) was acquired before and at the end of rehabilitative treatment performed with robotic device (Armeo-power). OUTCOMES: At the end of the rehabilitation program, most of the behavioral parameters, GAF and fMRI evaluation, showed a significative improvement. Moreover, fMRI showed a significantly increased functional activation within the sensory-motor network in the active, motor task. LESSONS: Our findings suggest a possible restorative effect of robotics on brain networks. Moreover, we may argue that GAF may be a valuable tool in assessing functional recovery after upper limb rehabilitation, especially of associated to fMRI examination. Wolters Kluwer Health 2019-04-26 /pmc/articles/PMC6831415/ /pubmed/31027053 http://dx.doi.org/10.1097/MD.0000000000015047 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | 5300 Bonanno, Lilla Russo, Margherita Bramanti, Alessia Calabrò, Rocco Salvatore Marino, Silvia Functional connectivity in multiple sclerosis after robotic rehabilitative treatment: A case report |
title | Functional connectivity in multiple sclerosis after robotic rehabilitative treatment: A case report |
title_full | Functional connectivity in multiple sclerosis after robotic rehabilitative treatment: A case report |
title_fullStr | Functional connectivity in multiple sclerosis after robotic rehabilitative treatment: A case report |
title_full_unstemmed | Functional connectivity in multiple sclerosis after robotic rehabilitative treatment: A case report |
title_short | Functional connectivity in multiple sclerosis after robotic rehabilitative treatment: A case report |
title_sort | functional connectivity in multiple sclerosis after robotic rehabilitative treatment: a case report |
topic | 5300 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831415/ https://www.ncbi.nlm.nih.gov/pubmed/31027053 http://dx.doi.org/10.1097/MD.0000000000015047 |
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