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A study on spleen transient elastography in predicting the degree of esophageal varices and bleeding

This study aims to investigate the value and determine the accuracy of spleen stiffness in predicting the degree of esophageal varices and bleeding in patients with liver cirrhosis. The age, gender, liver stiffness, spleen stiffness, and gastroscopy results of 124 inpatients or outpatients with live...

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Autores principales: Wang, Xie-Kui, Wang, Ping, Zhang, Yong, Qi, Sheng-Lin, Chi, Kun, Wang, Gong-Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831430/
https://www.ncbi.nlm.nih.gov/pubmed/30817578
http://dx.doi.org/10.1097/MD.0000000000014615
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author Wang, Xie-Kui
Wang, Ping
Zhang, Yong
Qi, Sheng-Lin
Chi, Kun
Wang, Gong-Chen
author_facet Wang, Xie-Kui
Wang, Ping
Zhang, Yong
Qi, Sheng-Lin
Chi, Kun
Wang, Gong-Chen
author_sort Wang, Xie-Kui
collection PubMed
description This study aims to investigate the value and determine the accuracy of spleen stiffness in predicting the degree of esophageal varices and bleeding in patients with liver cirrhosis. The age, gender, liver stiffness, spleen stiffness, and gastroscopy results of 124 inpatients or outpatients with liver cirrhosis and healthy volunteers, who underwent both gastroscopy and FibroScan testing in the fasting state, were retrospectively analyzed. According to the gastroscopy results, the patients and healthy volunteers were divided into six groups: varicose bleeding, severe varices, moderate varices, mild varices, no varices, and healthy control group. Then, the receiver operating characteristic curves were drawn, and the corresponding area under each curve was calculated and evaluated to predict the severity of varices based on the relevance of the area and its parameters. The area under the receiver operating characteristic curve of liver stiffness and spleen stiffness for predicting severe and moderate varices in the bleeding group was 0.955 and 0.989, respectively. The cut-off values were 29.6 kPa and 45.5 kPa, respectively. The area under the receiver operating characteristic curve of liver stiffness for predicting varicose bleeding was 0.860 (95% CI: 0.789–0.931). The liver stiffness cut-off value for predicting varicose bleeding was 33.2 kPa, with a specificity and sensitivity of 66.02% and 95.24%, respectively. The area under the receiver operating characteristic curve of spleen stiffness for predicting varicose bleeding was 0.923 (95% CI: 0.875–0.971). A spleen stiffness cut-off value of 55.2 kPa had a sensitivity and specificity of 90.48% and 86.41%, respectively. Spleen stiffness can predict the degree of esophageal varices and bleeding in liver cirrhosis patients, and has good predictive accuracy.
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spelling pubmed-68314302019-11-19 A study on spleen transient elastography in predicting the degree of esophageal varices and bleeding Wang, Xie-Kui Wang, Ping Zhang, Yong Qi, Sheng-Lin Chi, Kun Wang, Gong-Chen Medicine (Baltimore) 4500 This study aims to investigate the value and determine the accuracy of spleen stiffness in predicting the degree of esophageal varices and bleeding in patients with liver cirrhosis. The age, gender, liver stiffness, spleen stiffness, and gastroscopy results of 124 inpatients or outpatients with liver cirrhosis and healthy volunteers, who underwent both gastroscopy and FibroScan testing in the fasting state, were retrospectively analyzed. According to the gastroscopy results, the patients and healthy volunteers were divided into six groups: varicose bleeding, severe varices, moderate varices, mild varices, no varices, and healthy control group. Then, the receiver operating characteristic curves were drawn, and the corresponding area under each curve was calculated and evaluated to predict the severity of varices based on the relevance of the area and its parameters. The area under the receiver operating characteristic curve of liver stiffness and spleen stiffness for predicting severe and moderate varices in the bleeding group was 0.955 and 0.989, respectively. The cut-off values were 29.6 kPa and 45.5 kPa, respectively. The area under the receiver operating characteristic curve of liver stiffness for predicting varicose bleeding was 0.860 (95% CI: 0.789–0.931). The liver stiffness cut-off value for predicting varicose bleeding was 33.2 kPa, with a specificity and sensitivity of 66.02% and 95.24%, respectively. The area under the receiver operating characteristic curve of spleen stiffness for predicting varicose bleeding was 0.923 (95% CI: 0.875–0.971). A spleen stiffness cut-off value of 55.2 kPa had a sensitivity and specificity of 90.48% and 86.41%, respectively. Spleen stiffness can predict the degree of esophageal varices and bleeding in liver cirrhosis patients, and has good predictive accuracy. Wolters Kluwer Health 2019-03-01 /pmc/articles/PMC6831430/ /pubmed/30817578 http://dx.doi.org/10.1097/MD.0000000000014615 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle 4500
Wang, Xie-Kui
Wang, Ping
Zhang, Yong
Qi, Sheng-Lin
Chi, Kun
Wang, Gong-Chen
A study on spleen transient elastography in predicting the degree of esophageal varices and bleeding
title A study on spleen transient elastography in predicting the degree of esophageal varices and bleeding
title_full A study on spleen transient elastography in predicting the degree of esophageal varices and bleeding
title_fullStr A study on spleen transient elastography in predicting the degree of esophageal varices and bleeding
title_full_unstemmed A study on spleen transient elastography in predicting the degree of esophageal varices and bleeding
title_short A study on spleen transient elastography in predicting the degree of esophageal varices and bleeding
title_sort study on spleen transient elastography in predicting the degree of esophageal varices and bleeding
topic 4500
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831430/
https://www.ncbi.nlm.nih.gov/pubmed/30817578
http://dx.doi.org/10.1097/MD.0000000000014615
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