The yin and yang of imaging tumor associated macrophages with PET and MRI

Tumor associated macrophages (TAM) are key players in the cancer microenvironment. Molecular imaging modalities such as MRI and PET can be used to track and monitor TAM dynamics in tumors non-invasively, based on specific uptake and quantification of MRI-detectable nanoparticles or PET-detectable ra...

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Autores principales: Mukherjee, Sudip, Sonanini, Dominik, Maurer, Andreas, Daldrup-Link, Heike E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831464/
https://www.ncbi.nlm.nih.gov/pubmed/31695797
http://dx.doi.org/10.7150/thno.37306
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author Mukherjee, Sudip
Sonanini, Dominik
Maurer, Andreas
Daldrup-Link, Heike E.
author_facet Mukherjee, Sudip
Sonanini, Dominik
Maurer, Andreas
Daldrup-Link, Heike E.
author_sort Mukherjee, Sudip
collection PubMed
description Tumor associated macrophages (TAM) are key players in the cancer microenvironment. Molecular imaging modalities such as MRI and PET can be used to track and monitor TAM dynamics in tumors non-invasively, based on specific uptake and quantification of MRI-detectable nanoparticles or PET-detectable radiotracers. Particular molecular signatures can be leveraged to target anti-inflammatory TAM, which support tumor growth, and pro-inflammatory TAM, which suppress tumor growth. In addition, TAM-directed imaging probes can be designed to include immune modulating properties, thereby leading to combined diagnostic and therapeutic (theranostic) effects. In this review, we will discuss the complementary role of TAM-directed radiotracers and iron oxide nanoparticles for monitoring cancer immunotherapies with PET and MRI technologies. In addition, we will outline how TAM-directed imaging and therapy is interdependent and can be connected towards improved clinical outcomes
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spelling pubmed-68314642019-11-06 The yin and yang of imaging tumor associated macrophages with PET and MRI Mukherjee, Sudip Sonanini, Dominik Maurer, Andreas Daldrup-Link, Heike E. Theranostics Review Tumor associated macrophages (TAM) are key players in the cancer microenvironment. Molecular imaging modalities such as MRI and PET can be used to track and monitor TAM dynamics in tumors non-invasively, based on specific uptake and quantification of MRI-detectable nanoparticles or PET-detectable radiotracers. Particular molecular signatures can be leveraged to target anti-inflammatory TAM, which support tumor growth, and pro-inflammatory TAM, which suppress tumor growth. In addition, TAM-directed imaging probes can be designed to include immune modulating properties, thereby leading to combined diagnostic and therapeutic (theranostic) effects. In this review, we will discuss the complementary role of TAM-directed radiotracers and iron oxide nanoparticles for monitoring cancer immunotherapies with PET and MRI technologies. In addition, we will outline how TAM-directed imaging and therapy is interdependent and can be connected towards improved clinical outcomes Ivyspring International Publisher 2019-10-15 /pmc/articles/PMC6831464/ /pubmed/31695797 http://dx.doi.org/10.7150/thno.37306 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Mukherjee, Sudip
Sonanini, Dominik
Maurer, Andreas
Daldrup-Link, Heike E.
The yin and yang of imaging tumor associated macrophages with PET and MRI
title The yin and yang of imaging tumor associated macrophages with PET and MRI
title_full The yin and yang of imaging tumor associated macrophages with PET and MRI
title_fullStr The yin and yang of imaging tumor associated macrophages with PET and MRI
title_full_unstemmed The yin and yang of imaging tumor associated macrophages with PET and MRI
title_short The yin and yang of imaging tumor associated macrophages with PET and MRI
title_sort yin and yang of imaging tumor associated macrophages with pet and mri
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831464/
https://www.ncbi.nlm.nih.gov/pubmed/31695797
http://dx.doi.org/10.7150/thno.37306
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