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Phase I study of cancer lesion-targeted microwave coagulation therapy for localized prostate cancer: A pilot clinical study protocol

BACKGROUND: Whole-gland therapy for prostate cancer, which might cause more harm than no therapy (observation or active surveillance), might be a overtreatment. In order to avoid overtreatment as well as undertreatment of localize prostate cancer, novel strategy of organ-preserving therapies have be...

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Autores principales: Yamada, Yasuhiro, Shiaishi, Takumi, Ueno, Akihisa, Kaneko, Masatomo, Inoue, Yuta, Fujihara, Atsuko, Hongo, Fumiya, Ukimura, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831715/
https://www.ncbi.nlm.nih.gov/pubmed/31701044
http://dx.doi.org/10.1016/j.conctc.2019.100471
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author Yamada, Yasuhiro
Shiaishi, Takumi
Ueno, Akihisa
Kaneko, Masatomo
Inoue, Yuta
Fujihara, Atsuko
Hongo, Fumiya
Ukimura, Osamu
author_facet Yamada, Yasuhiro
Shiaishi, Takumi
Ueno, Akihisa
Kaneko, Masatomo
Inoue, Yuta
Fujihara, Atsuko
Hongo, Fumiya
Ukimura, Osamu
author_sort Yamada, Yasuhiro
collection PubMed
description BACKGROUND: Whole-gland therapy for prostate cancer, which might cause more harm than no therapy (observation or active surveillance), might be a overtreatment. In order to avoid overtreatment as well as undertreatment of localize prostate cancer, novel strategy of organ-preserving therapies have been developed to achieve both cancer control and functional preservation. For the therapeutic techniques, microwave ablation would be an option for lesion-targeted focal therapy to eradicate biopsy-proven cancer lesion with its safety margin. Following our recent pilot clinical study of lesion-targeted focal cryotherapy, prospective clinical trial was designed to investigate the safety and therapeutic effects of lesion-targeted microwave therapy for localized prostate cancer. METHODS: This is a single-center, phase I, clinical study to evaluate primarily the safety of lesion-targeted focal microwave treatment for prostate cancer. Patients with a magnetic resonance imaging (MRI)-visible, MR-ultrasound image-fusion targeted biopsy-proven clinically significant cancer will be enrolled. The target sample size is 5. Transrectal ultrasound-guided focal microwave ablation will be performed under general anesthesia. The primary endpoint is adverse events after microwave focal therapy. Secondary endpoint includes to assess both cancer control and quality of life (functional preservation). DISCUSSION: This single-center, phase I, clinical study aims to evaluate the safety and efficacy of lesion-targeted focal microwave treatment for prostate cancer. The importance of this clinical trial is that it may establish new treatment for prostate cancer. TRIAL REGISTRATION: This study was registered with Japan Registry of Clinical Trials (jRCTs052190026).
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spelling pubmed-68317152019-11-07 Phase I study of cancer lesion-targeted microwave coagulation therapy for localized prostate cancer: A pilot clinical study protocol Yamada, Yasuhiro Shiaishi, Takumi Ueno, Akihisa Kaneko, Masatomo Inoue, Yuta Fujihara, Atsuko Hongo, Fumiya Ukimura, Osamu Contemp Clin Trials Commun Article BACKGROUND: Whole-gland therapy for prostate cancer, which might cause more harm than no therapy (observation or active surveillance), might be a overtreatment. In order to avoid overtreatment as well as undertreatment of localize prostate cancer, novel strategy of organ-preserving therapies have been developed to achieve both cancer control and functional preservation. For the therapeutic techniques, microwave ablation would be an option for lesion-targeted focal therapy to eradicate biopsy-proven cancer lesion with its safety margin. Following our recent pilot clinical study of lesion-targeted focal cryotherapy, prospective clinical trial was designed to investigate the safety and therapeutic effects of lesion-targeted microwave therapy for localized prostate cancer. METHODS: This is a single-center, phase I, clinical study to evaluate primarily the safety of lesion-targeted focal microwave treatment for prostate cancer. Patients with a magnetic resonance imaging (MRI)-visible, MR-ultrasound image-fusion targeted biopsy-proven clinically significant cancer will be enrolled. The target sample size is 5. Transrectal ultrasound-guided focal microwave ablation will be performed under general anesthesia. The primary endpoint is adverse events after microwave focal therapy. Secondary endpoint includes to assess both cancer control and quality of life (functional preservation). DISCUSSION: This single-center, phase I, clinical study aims to evaluate the safety and efficacy of lesion-targeted focal microwave treatment for prostate cancer. The importance of this clinical trial is that it may establish new treatment for prostate cancer. TRIAL REGISTRATION: This study was registered with Japan Registry of Clinical Trials (jRCTs052190026). Elsevier 2019-10-12 /pmc/articles/PMC6831715/ /pubmed/31701044 http://dx.doi.org/10.1016/j.conctc.2019.100471 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Yamada, Yasuhiro
Shiaishi, Takumi
Ueno, Akihisa
Kaneko, Masatomo
Inoue, Yuta
Fujihara, Atsuko
Hongo, Fumiya
Ukimura, Osamu
Phase I study of cancer lesion-targeted microwave coagulation therapy for localized prostate cancer: A pilot clinical study protocol
title Phase I study of cancer lesion-targeted microwave coagulation therapy for localized prostate cancer: A pilot clinical study protocol
title_full Phase I study of cancer lesion-targeted microwave coagulation therapy for localized prostate cancer: A pilot clinical study protocol
title_fullStr Phase I study of cancer lesion-targeted microwave coagulation therapy for localized prostate cancer: A pilot clinical study protocol
title_full_unstemmed Phase I study of cancer lesion-targeted microwave coagulation therapy for localized prostate cancer: A pilot clinical study protocol
title_short Phase I study of cancer lesion-targeted microwave coagulation therapy for localized prostate cancer: A pilot clinical study protocol
title_sort phase i study of cancer lesion-targeted microwave coagulation therapy for localized prostate cancer: a pilot clinical study protocol
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831715/
https://www.ncbi.nlm.nih.gov/pubmed/31701044
http://dx.doi.org/10.1016/j.conctc.2019.100471
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