Cargando…
Phase I study of cancer lesion-targeted microwave coagulation therapy for localized prostate cancer: A pilot clinical study protocol
BACKGROUND: Whole-gland therapy for prostate cancer, which might cause more harm than no therapy (observation or active surveillance), might be a overtreatment. In order to avoid overtreatment as well as undertreatment of localize prostate cancer, novel strategy of organ-preserving therapies have be...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831715/ https://www.ncbi.nlm.nih.gov/pubmed/31701044 http://dx.doi.org/10.1016/j.conctc.2019.100471 |
_version_ | 1783466033752834048 |
---|---|
author | Yamada, Yasuhiro Shiaishi, Takumi Ueno, Akihisa Kaneko, Masatomo Inoue, Yuta Fujihara, Atsuko Hongo, Fumiya Ukimura, Osamu |
author_facet | Yamada, Yasuhiro Shiaishi, Takumi Ueno, Akihisa Kaneko, Masatomo Inoue, Yuta Fujihara, Atsuko Hongo, Fumiya Ukimura, Osamu |
author_sort | Yamada, Yasuhiro |
collection | PubMed |
description | BACKGROUND: Whole-gland therapy for prostate cancer, which might cause more harm than no therapy (observation or active surveillance), might be a overtreatment. In order to avoid overtreatment as well as undertreatment of localize prostate cancer, novel strategy of organ-preserving therapies have been developed to achieve both cancer control and functional preservation. For the therapeutic techniques, microwave ablation would be an option for lesion-targeted focal therapy to eradicate biopsy-proven cancer lesion with its safety margin. Following our recent pilot clinical study of lesion-targeted focal cryotherapy, prospective clinical trial was designed to investigate the safety and therapeutic effects of lesion-targeted microwave therapy for localized prostate cancer. METHODS: This is a single-center, phase I, clinical study to evaluate primarily the safety of lesion-targeted focal microwave treatment for prostate cancer. Patients with a magnetic resonance imaging (MRI)-visible, MR-ultrasound image-fusion targeted biopsy-proven clinically significant cancer will be enrolled. The target sample size is 5. Transrectal ultrasound-guided focal microwave ablation will be performed under general anesthesia. The primary endpoint is adverse events after microwave focal therapy. Secondary endpoint includes to assess both cancer control and quality of life (functional preservation). DISCUSSION: This single-center, phase I, clinical study aims to evaluate the safety and efficacy of lesion-targeted focal microwave treatment for prostate cancer. The importance of this clinical trial is that it may establish new treatment for prostate cancer. TRIAL REGISTRATION: This study was registered with Japan Registry of Clinical Trials (jRCTs052190026). |
format | Online Article Text |
id | pubmed-6831715 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-68317152019-11-07 Phase I study of cancer lesion-targeted microwave coagulation therapy for localized prostate cancer: A pilot clinical study protocol Yamada, Yasuhiro Shiaishi, Takumi Ueno, Akihisa Kaneko, Masatomo Inoue, Yuta Fujihara, Atsuko Hongo, Fumiya Ukimura, Osamu Contemp Clin Trials Commun Article BACKGROUND: Whole-gland therapy for prostate cancer, which might cause more harm than no therapy (observation or active surveillance), might be a overtreatment. In order to avoid overtreatment as well as undertreatment of localize prostate cancer, novel strategy of organ-preserving therapies have been developed to achieve both cancer control and functional preservation. For the therapeutic techniques, microwave ablation would be an option for lesion-targeted focal therapy to eradicate biopsy-proven cancer lesion with its safety margin. Following our recent pilot clinical study of lesion-targeted focal cryotherapy, prospective clinical trial was designed to investigate the safety and therapeutic effects of lesion-targeted microwave therapy for localized prostate cancer. METHODS: This is a single-center, phase I, clinical study to evaluate primarily the safety of lesion-targeted focal microwave treatment for prostate cancer. Patients with a magnetic resonance imaging (MRI)-visible, MR-ultrasound image-fusion targeted biopsy-proven clinically significant cancer will be enrolled. The target sample size is 5. Transrectal ultrasound-guided focal microwave ablation will be performed under general anesthesia. The primary endpoint is adverse events after microwave focal therapy. Secondary endpoint includes to assess both cancer control and quality of life (functional preservation). DISCUSSION: This single-center, phase I, clinical study aims to evaluate the safety and efficacy of lesion-targeted focal microwave treatment for prostate cancer. The importance of this clinical trial is that it may establish new treatment for prostate cancer. TRIAL REGISTRATION: This study was registered with Japan Registry of Clinical Trials (jRCTs052190026). Elsevier 2019-10-12 /pmc/articles/PMC6831715/ /pubmed/31701044 http://dx.doi.org/10.1016/j.conctc.2019.100471 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Yamada, Yasuhiro Shiaishi, Takumi Ueno, Akihisa Kaneko, Masatomo Inoue, Yuta Fujihara, Atsuko Hongo, Fumiya Ukimura, Osamu Phase I study of cancer lesion-targeted microwave coagulation therapy for localized prostate cancer: A pilot clinical study protocol |
title | Phase I study of cancer lesion-targeted microwave coagulation therapy for localized prostate cancer: A pilot clinical study protocol |
title_full | Phase I study of cancer lesion-targeted microwave coagulation therapy for localized prostate cancer: A pilot clinical study protocol |
title_fullStr | Phase I study of cancer lesion-targeted microwave coagulation therapy for localized prostate cancer: A pilot clinical study protocol |
title_full_unstemmed | Phase I study of cancer lesion-targeted microwave coagulation therapy for localized prostate cancer: A pilot clinical study protocol |
title_short | Phase I study of cancer lesion-targeted microwave coagulation therapy for localized prostate cancer: A pilot clinical study protocol |
title_sort | phase i study of cancer lesion-targeted microwave coagulation therapy for localized prostate cancer: a pilot clinical study protocol |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831715/ https://www.ncbi.nlm.nih.gov/pubmed/31701044 http://dx.doi.org/10.1016/j.conctc.2019.100471 |
work_keys_str_mv | AT yamadayasuhiro phaseistudyofcancerlesiontargetedmicrowavecoagulationtherapyforlocalizedprostatecancerapilotclinicalstudyprotocol AT shiaishitakumi phaseistudyofcancerlesiontargetedmicrowavecoagulationtherapyforlocalizedprostatecancerapilotclinicalstudyprotocol AT uenoakihisa phaseistudyofcancerlesiontargetedmicrowavecoagulationtherapyforlocalizedprostatecancerapilotclinicalstudyprotocol AT kanekomasatomo phaseistudyofcancerlesiontargetedmicrowavecoagulationtherapyforlocalizedprostatecancerapilotclinicalstudyprotocol AT inoueyuta phaseistudyofcancerlesiontargetedmicrowavecoagulationtherapyforlocalizedprostatecancerapilotclinicalstudyprotocol AT fujiharaatsuko phaseistudyofcancerlesiontargetedmicrowavecoagulationtherapyforlocalizedprostatecancerapilotclinicalstudyprotocol AT hongofumiya phaseistudyofcancerlesiontargetedmicrowavecoagulationtherapyforlocalizedprostatecancerapilotclinicalstudyprotocol AT ukimuraosamu phaseistudyofcancerlesiontargetedmicrowavecoagulationtherapyforlocalizedprostatecancerapilotclinicalstudyprotocol |