Molecular characterization of multidrug-resistance in Gram-negative bacteria from the Peshawar teaching hospital, Pakistan

Extended-spectrum β-lactamases, carbapenemases, 16S rRNA methylases conferring pan-drug aminoglycoside resistance and colistin resistance were investigated among Gram-negative bacteria recovered from clinical samples (infections) from 200 individuals hospitalized at the Khyber Teaching Hospital of P...

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Autores principales: Masseron, A., Poirel, L., Jamil Ali, B., Syed, M.A., Nordmann, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831882/
https://www.ncbi.nlm.nih.gov/pubmed/31709068
http://dx.doi.org/10.1016/j.nmni.2019.100605
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author Masseron, A.
Poirel, L.
Jamil Ali, B.
Syed, M.A.
Nordmann, P.
author_facet Masseron, A.
Poirel, L.
Jamil Ali, B.
Syed, M.A.
Nordmann, P.
author_sort Masseron, A.
collection PubMed
description Extended-spectrum β-lactamases, carbapenemases, 16S rRNA methylases conferring pan-drug aminoglycoside resistance and colistin resistance were investigated among Gram-negative bacteria recovered from clinical samples (infections) from 200 individuals hospitalized at the Khyber Teaching Hospital of Peshawar, north Pakistan, from December 2017 to March 2018. Out of 65 isolates recovered, 19% were carbapenem resistant and 16% carried a bla(NDM-1) gene, confirming the widespread distribution of NDM producers in this country. The association of the NDM carbapenem-resistance determinant, together with the extended-spectrum β-lactamase CTX-M-15 and 16S rRNA methylases, was frequent, explaining the multidrug-resistance pattern observed. All isolates remained susceptible to colistin.
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spelling pubmed-68318822019-11-08 Molecular characterization of multidrug-resistance in Gram-negative bacteria from the Peshawar teaching hospital, Pakistan Masseron, A. Poirel, L. Jamil Ali, B. Syed, M.A. Nordmann, P. New Microbes New Infect Original Article Extended-spectrum β-lactamases, carbapenemases, 16S rRNA methylases conferring pan-drug aminoglycoside resistance and colistin resistance were investigated among Gram-negative bacteria recovered from clinical samples (infections) from 200 individuals hospitalized at the Khyber Teaching Hospital of Peshawar, north Pakistan, from December 2017 to March 2018. Out of 65 isolates recovered, 19% were carbapenem resistant and 16% carried a bla(NDM-1) gene, confirming the widespread distribution of NDM producers in this country. The association of the NDM carbapenem-resistance determinant, together with the extended-spectrum β-lactamase CTX-M-15 and 16S rRNA methylases, was frequent, explaining the multidrug-resistance pattern observed. All isolates remained susceptible to colistin. Elsevier 2019-10-11 /pmc/articles/PMC6831882/ /pubmed/31709068 http://dx.doi.org/10.1016/j.nmni.2019.100605 Text en © 2019 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Masseron, A.
Poirel, L.
Jamil Ali, B.
Syed, M.A.
Nordmann, P.
Molecular characterization of multidrug-resistance in Gram-negative bacteria from the Peshawar teaching hospital, Pakistan
title Molecular characterization of multidrug-resistance in Gram-negative bacteria from the Peshawar teaching hospital, Pakistan
title_full Molecular characterization of multidrug-resistance in Gram-negative bacteria from the Peshawar teaching hospital, Pakistan
title_fullStr Molecular characterization of multidrug-resistance in Gram-negative bacteria from the Peshawar teaching hospital, Pakistan
title_full_unstemmed Molecular characterization of multidrug-resistance in Gram-negative bacteria from the Peshawar teaching hospital, Pakistan
title_short Molecular characterization of multidrug-resistance in Gram-negative bacteria from the Peshawar teaching hospital, Pakistan
title_sort molecular characterization of multidrug-resistance in gram-negative bacteria from the peshawar teaching hospital, pakistan
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831882/
https://www.ncbi.nlm.nih.gov/pubmed/31709068
http://dx.doi.org/10.1016/j.nmni.2019.100605
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