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Closed-Loop Acoustic Stimulation Enhances Sleep Oscillations But Not Memory Performance

Slow oscillations and spindle activity during non-rapid eye movement sleep have been implicated in memory consolidation. Closed-loop acoustic stimulation has previously been shown to enhance slow oscillations and spindle activity during sleep and improve verbal associative memory. We assessed the ef...

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Autores principales: Henin, Simon, Borges, Helen, Shankar, Anita, Sarac, Cansu, Melloni, Lucia, Friedman, Daniel, Flinker, Adeen, Parra, Lucas C., Buzsaki, Gyorgy, Devinsky, Orrin, Liu, Anli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831893/
https://www.ncbi.nlm.nih.gov/pubmed/31604814
http://dx.doi.org/10.1523/ENEURO.0306-19.2019
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author Henin, Simon
Borges, Helen
Shankar, Anita
Sarac, Cansu
Melloni, Lucia
Friedman, Daniel
Flinker, Adeen
Parra, Lucas C.
Buzsaki, Gyorgy
Devinsky, Orrin
Liu, Anli
author_facet Henin, Simon
Borges, Helen
Shankar, Anita
Sarac, Cansu
Melloni, Lucia
Friedman, Daniel
Flinker, Adeen
Parra, Lucas C.
Buzsaki, Gyorgy
Devinsky, Orrin
Liu, Anli
author_sort Henin, Simon
collection PubMed
description Slow oscillations and spindle activity during non-rapid eye movement sleep have been implicated in memory consolidation. Closed-loop acoustic stimulation has previously been shown to enhance slow oscillations and spindle activity during sleep and improve verbal associative memory. We assessed the effect of closed-loop acoustic stimulation during a daytime nap on a virtual reality spatial navigation task in 12 healthy human subjects in a randomized within-subject crossover design. We show robust enhancement of slow oscillation and spindle activity during sleep. However, no effects on behavioral performance were observed when comparing real versus sham stimulation. To explore whether memory enhancement effects were task specific and dependent on nocturnal sleep, in a second experiment with 19 healthy subjects, we aimed to replicate a previous study that used closed-loop acoustic stimulation to enhance memory for word pairs. The methods used were as close as possible to those used in the original study, except that we used a double-blind protocol, in which both subject and experimenter were unaware of the test condition. Again, we successfully enhanced slow oscillation and spindle power, but again did not strengthen associative memory performance with stimulation. We conclude that enhancement of sleep oscillations may be insufficient to enhance memory performance in spatial navigation or verbal association tasks, and provide possible explanations for lack of behavioral replication.
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spelling pubmed-68318932019-11-06 Closed-Loop Acoustic Stimulation Enhances Sleep Oscillations But Not Memory Performance Henin, Simon Borges, Helen Shankar, Anita Sarac, Cansu Melloni, Lucia Friedman, Daniel Flinker, Adeen Parra, Lucas C. Buzsaki, Gyorgy Devinsky, Orrin Liu, Anli eNeuro Negative Results Slow oscillations and spindle activity during non-rapid eye movement sleep have been implicated in memory consolidation. Closed-loop acoustic stimulation has previously been shown to enhance slow oscillations and spindle activity during sleep and improve verbal associative memory. We assessed the effect of closed-loop acoustic stimulation during a daytime nap on a virtual reality spatial navigation task in 12 healthy human subjects in a randomized within-subject crossover design. We show robust enhancement of slow oscillation and spindle activity during sleep. However, no effects on behavioral performance were observed when comparing real versus sham stimulation. To explore whether memory enhancement effects were task specific and dependent on nocturnal sleep, in a second experiment with 19 healthy subjects, we aimed to replicate a previous study that used closed-loop acoustic stimulation to enhance memory for word pairs. The methods used were as close as possible to those used in the original study, except that we used a double-blind protocol, in which both subject and experimenter were unaware of the test condition. Again, we successfully enhanced slow oscillation and spindle power, but again did not strengthen associative memory performance with stimulation. We conclude that enhancement of sleep oscillations may be insufficient to enhance memory performance in spatial navigation or verbal association tasks, and provide possible explanations for lack of behavioral replication. Society for Neuroscience 2019-11-05 /pmc/articles/PMC6831893/ /pubmed/31604814 http://dx.doi.org/10.1523/ENEURO.0306-19.2019 Text en Copyright © 2019 Henin et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Negative Results
Henin, Simon
Borges, Helen
Shankar, Anita
Sarac, Cansu
Melloni, Lucia
Friedman, Daniel
Flinker, Adeen
Parra, Lucas C.
Buzsaki, Gyorgy
Devinsky, Orrin
Liu, Anli
Closed-Loop Acoustic Stimulation Enhances Sleep Oscillations But Not Memory Performance
title Closed-Loop Acoustic Stimulation Enhances Sleep Oscillations But Not Memory Performance
title_full Closed-Loop Acoustic Stimulation Enhances Sleep Oscillations But Not Memory Performance
title_fullStr Closed-Loop Acoustic Stimulation Enhances Sleep Oscillations But Not Memory Performance
title_full_unstemmed Closed-Loop Acoustic Stimulation Enhances Sleep Oscillations But Not Memory Performance
title_short Closed-Loop Acoustic Stimulation Enhances Sleep Oscillations But Not Memory Performance
title_sort closed-loop acoustic stimulation enhances sleep oscillations but not memory performance
topic Negative Results
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831893/
https://www.ncbi.nlm.nih.gov/pubmed/31604814
http://dx.doi.org/10.1523/ENEURO.0306-19.2019
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