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Characteristic alteration of subcortical nuclei shape in medication-free patients with obsessive-compulsive disorder

BACKGROUND: Subcortical nuclei are important components in the pathology model of obsessive-compulsive disorder (OCD), and subregions of these structures subserve different functions that may distinctively contribute to OCD symptoms. Exploration of the subregional-level profile of structural abnorma...

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Autores principales: Zhang, Lianqing, Hu, Xinyu, Li, Hailong, Lu, Lu, Li, Bin, Hu, Xiaoxiao, Bu, Xuan, Tang, Shi, Tang, Wanjie, Liu, Naici, Yang, Yanchun, Gong, Qiyong, Huang, Xiaoqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831899/
https://www.ncbi.nlm.nih.gov/pubmed/31670068
http://dx.doi.org/10.1016/j.nicl.2019.102040
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author Zhang, Lianqing
Hu, Xinyu
Li, Hailong
Lu, Lu
Li, Bin
Hu, Xiaoxiao
Bu, Xuan
Tang, Shi
Tang, Wanjie
Liu, Naici
Yang, Yanchun
Gong, Qiyong
Huang, Xiaoqi
author_facet Zhang, Lianqing
Hu, Xinyu
Li, Hailong
Lu, Lu
Li, Bin
Hu, Xiaoxiao
Bu, Xuan
Tang, Shi
Tang, Wanjie
Liu, Naici
Yang, Yanchun
Gong, Qiyong
Huang, Xiaoqi
author_sort Zhang, Lianqing
collection PubMed
description BACKGROUND: Subcortical nuclei are important components in the pathology model of obsessive-compulsive disorder (OCD), and subregions of these structures subserve different functions that may distinctively contribute to OCD symptoms. Exploration of the subregional-level profile of structural abnormalities of these nuclei is needed to develop a better understanding of the neural mechanism of OCD. METHODS: A total of 83 medication-free, non-comorbid OCD patients and 93 age- and sex-matched healthy controls were recruited, and high-resolution T1-weighted MR images were obtained for all participants. The volume and shape of the subcortical nuclei (including the nucleus accumbens, amygdala, caudate, pallidum, putamen and thalamus) were quantified and compared with an automated parcellation approach and vertex-wise shape analysis using FSL-FIRST software. Sex differences in these measurements were also explored with an exploratory subgroup analysis. RESULTS: Volumetric analysis showed no significant differences between patients and healthy control subjects. Relative to healthy control subjects, the OCD patients showed an expansion of the lateral amygdala (right hemisphere) and right pallidum. These deformities were associated with illness duration and symptom severity of OCD. Exploratory subgroup analysis by sex revealed amygdala deformity in male patients and caudate deformity in female patients. CONCLUSIONS: The lateral amygdala and the dorsal pallidum were associated with OCD. Neuroanatomic evidence of sexual dimorphism was also found in OCD. Our study not only provides deeper insight into how these structures contribute to OCD symptoms by revealing these subregional-level deformities but also suggests that gender effects may be important in OCD studies.
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spelling pubmed-68318992019-11-08 Characteristic alteration of subcortical nuclei shape in medication-free patients with obsessive-compulsive disorder Zhang, Lianqing Hu, Xinyu Li, Hailong Lu, Lu Li, Bin Hu, Xiaoxiao Bu, Xuan Tang, Shi Tang, Wanjie Liu, Naici Yang, Yanchun Gong, Qiyong Huang, Xiaoqi Neuroimage Clin Regular Article BACKGROUND: Subcortical nuclei are important components in the pathology model of obsessive-compulsive disorder (OCD), and subregions of these structures subserve different functions that may distinctively contribute to OCD symptoms. Exploration of the subregional-level profile of structural abnormalities of these nuclei is needed to develop a better understanding of the neural mechanism of OCD. METHODS: A total of 83 medication-free, non-comorbid OCD patients and 93 age- and sex-matched healthy controls were recruited, and high-resolution T1-weighted MR images were obtained for all participants. The volume and shape of the subcortical nuclei (including the nucleus accumbens, amygdala, caudate, pallidum, putamen and thalamus) were quantified and compared with an automated parcellation approach and vertex-wise shape analysis using FSL-FIRST software. Sex differences in these measurements were also explored with an exploratory subgroup analysis. RESULTS: Volumetric analysis showed no significant differences between patients and healthy control subjects. Relative to healthy control subjects, the OCD patients showed an expansion of the lateral amygdala (right hemisphere) and right pallidum. These deformities were associated with illness duration and symptom severity of OCD. Exploratory subgroup analysis by sex revealed amygdala deformity in male patients and caudate deformity in female patients. CONCLUSIONS: The lateral amygdala and the dorsal pallidum were associated with OCD. Neuroanatomic evidence of sexual dimorphism was also found in OCD. Our study not only provides deeper insight into how these structures contribute to OCD symptoms by revealing these subregional-level deformities but also suggests that gender effects may be important in OCD studies. Elsevier 2019-10-18 /pmc/articles/PMC6831899/ /pubmed/31670068 http://dx.doi.org/10.1016/j.nicl.2019.102040 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Zhang, Lianqing
Hu, Xinyu
Li, Hailong
Lu, Lu
Li, Bin
Hu, Xiaoxiao
Bu, Xuan
Tang, Shi
Tang, Wanjie
Liu, Naici
Yang, Yanchun
Gong, Qiyong
Huang, Xiaoqi
Characteristic alteration of subcortical nuclei shape in medication-free patients with obsessive-compulsive disorder
title Characteristic alteration of subcortical nuclei shape in medication-free patients with obsessive-compulsive disorder
title_full Characteristic alteration of subcortical nuclei shape in medication-free patients with obsessive-compulsive disorder
title_fullStr Characteristic alteration of subcortical nuclei shape in medication-free patients with obsessive-compulsive disorder
title_full_unstemmed Characteristic alteration of subcortical nuclei shape in medication-free patients with obsessive-compulsive disorder
title_short Characteristic alteration of subcortical nuclei shape in medication-free patients with obsessive-compulsive disorder
title_sort characteristic alteration of subcortical nuclei shape in medication-free patients with obsessive-compulsive disorder
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831899/
https://www.ncbi.nlm.nih.gov/pubmed/31670068
http://dx.doi.org/10.1016/j.nicl.2019.102040
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