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Elucidation of the time-dependent degradation process in insoluble hyaluronic acid formulations with a controlled degradation rate
Degradation rate of hyaluronic acid to prolong its stability in vivo would be beneficial. We investigated a potential solution for prolonging the stability of hyaluronic acid within the body. We focused on decreasing the swelling ratio to slow the degradation rate of hyaluronic acid by insolubilizin...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831965/ https://www.ncbi.nlm.nih.gov/pubmed/31723398 http://dx.doi.org/10.1177/2041731419885032 |
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author | Uemura, Akiko Ogawa, Shingo Isono, Yasuyuki Tanaka, Ryou |
author_facet | Uemura, Akiko Ogawa, Shingo Isono, Yasuyuki Tanaka, Ryou |
author_sort | Uemura, Akiko |
collection | PubMed |
description | Degradation rate of hyaluronic acid to prolong its stability in vivo would be beneficial. We investigated a potential solution for prolonging the stability of hyaluronic acid within the body. We focused on decreasing the swelling ratio to slow the degradation rate of hyaluronic acid by insolubilizing sodium hyaluronate without using potentially harmful substances such as crosslinkers or modifiers. Hyaluronic acid formulations were created with three different swelling ratios and time-dependent morphological changes in hyaluronic acid formulations and were scored based on each swelling ratio. In vivo degradation was modeled in simulated body fluid and the extent of decay of test membranes were monitored over time. Results showed that, by adjusting the swelling ratio, the degradation rate of hyaluronic acid formulation could be controlled. Our research could lead to improvements in many products, not only preventive materials for postoperative adhesions, but also pharmaceutical products such as osteoarthritis treatments and cosmetic medicines. |
format | Online Article Text |
id | pubmed-6831965 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-68319652019-11-13 Elucidation of the time-dependent degradation process in insoluble hyaluronic acid formulations with a controlled degradation rate Uemura, Akiko Ogawa, Shingo Isono, Yasuyuki Tanaka, Ryou J Tissue Eng Original Article Degradation rate of hyaluronic acid to prolong its stability in vivo would be beneficial. We investigated a potential solution for prolonging the stability of hyaluronic acid within the body. We focused on decreasing the swelling ratio to slow the degradation rate of hyaluronic acid by insolubilizing sodium hyaluronate without using potentially harmful substances such as crosslinkers or modifiers. Hyaluronic acid formulations were created with three different swelling ratios and time-dependent morphological changes in hyaluronic acid formulations and were scored based on each swelling ratio. In vivo degradation was modeled in simulated body fluid and the extent of decay of test membranes were monitored over time. Results showed that, by adjusting the swelling ratio, the degradation rate of hyaluronic acid formulation could be controlled. Our research could lead to improvements in many products, not only preventive materials for postoperative adhesions, but also pharmaceutical products such as osteoarthritis treatments and cosmetic medicines. SAGE Publications 2019-11-05 /pmc/articles/PMC6831965/ /pubmed/31723398 http://dx.doi.org/10.1177/2041731419885032 Text en © The Author(s) 2019 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Article Uemura, Akiko Ogawa, Shingo Isono, Yasuyuki Tanaka, Ryou Elucidation of the time-dependent degradation process in insoluble hyaluronic acid formulations with a controlled degradation rate |
title | Elucidation of the time-dependent degradation process in insoluble
hyaluronic acid formulations with a controlled degradation rate |
title_full | Elucidation of the time-dependent degradation process in insoluble
hyaluronic acid formulations with a controlled degradation rate |
title_fullStr | Elucidation of the time-dependent degradation process in insoluble
hyaluronic acid formulations with a controlled degradation rate |
title_full_unstemmed | Elucidation of the time-dependent degradation process in insoluble
hyaluronic acid formulations with a controlled degradation rate |
title_short | Elucidation of the time-dependent degradation process in insoluble
hyaluronic acid formulations with a controlled degradation rate |
title_sort | elucidation of the time-dependent degradation process in insoluble
hyaluronic acid formulations with a controlled degradation rate |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831965/ https://www.ncbi.nlm.nih.gov/pubmed/31723398 http://dx.doi.org/10.1177/2041731419885032 |
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