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Serum hepcidin levels in multiple sclerosis
BACKGROUND: Brain iron accumulation is associated with multiple sclerosis (MS). Hepcidin is the master regulator of iron homeostasis and distribution. Dysregulation of hepcidin is a feature of different chronic inflammatory diseases but has not been investigated in MS so far. OBJECTIVE: The aim of t...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831977/ https://www.ncbi.nlm.nih.gov/pubmed/31723437 http://dx.doi.org/10.1177/2055217319885984 |
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author | Bsteh, Gabriel Haschka, David Tymoszuk, Piotr Berek, Klaus Petzer, Verena Hegen, Harald Wurth, Sebastian Auer, Michael Zinganell, Anne Pauli, Franziska Di Deisenhammer, Florian Weiss, Guenter Berger, Thomas |
author_facet | Bsteh, Gabriel Haschka, David Tymoszuk, Piotr Berek, Klaus Petzer, Verena Hegen, Harald Wurth, Sebastian Auer, Michael Zinganell, Anne Pauli, Franziska Di Deisenhammer, Florian Weiss, Guenter Berger, Thomas |
author_sort | Bsteh, Gabriel |
collection | PubMed |
description | BACKGROUND: Brain iron accumulation is associated with multiple sclerosis (MS). Hepcidin is the master regulator of iron homeostasis and distribution. Dysregulation of hepcidin is a feature of different chronic inflammatory diseases but has not been investigated in MS so far. OBJECTIVE: The aim of this study was to determine serum hepcidin levels of MS patients and healthy volunteers serving as controls and to investigate possible relations between hepcidin levels, disease activity and disease course. METHODS: In a cross-sectional design, we measured serum hepcidin levels in 71 MS patients and 16 healthy controls (HC). MS patients were sub-grouped in active relapsing–remitting MS (aRRMS), inactive (i)RRMS, active progressive MS (aPMS) and inactive (i)PMS. Blood parameters were measured by standard laboratory methods. RESULTS: Median hepcidin levels were 26.9 ng/ml (confidence interval (CI) 22.8; 30.9) in MS and 17.3 ng/ml (CI 12.8; 23.4) in HC with significant age and sex effects. Hepcidin correlates were in line with hepcidin as an indicator of iron stores. After correction for age and sex, hepcidin was neither associated with MS subgroups nor degree of disability and occurrence of relapses. CONCLUSIONS: Serum hepcidin levels are not associated with disease activity and disease course in MS. |
format | Online Article Text |
id | pubmed-6831977 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-68319772019-11-13 Serum hepcidin levels in multiple sclerosis Bsteh, Gabriel Haschka, David Tymoszuk, Piotr Berek, Klaus Petzer, Verena Hegen, Harald Wurth, Sebastian Auer, Michael Zinganell, Anne Pauli, Franziska Di Deisenhammer, Florian Weiss, Guenter Berger, Thomas Mult Scler J Exp Transl Clin Original Research Paper BACKGROUND: Brain iron accumulation is associated with multiple sclerosis (MS). Hepcidin is the master regulator of iron homeostasis and distribution. Dysregulation of hepcidin is a feature of different chronic inflammatory diseases but has not been investigated in MS so far. OBJECTIVE: The aim of this study was to determine serum hepcidin levels of MS patients and healthy volunteers serving as controls and to investigate possible relations between hepcidin levels, disease activity and disease course. METHODS: In a cross-sectional design, we measured serum hepcidin levels in 71 MS patients and 16 healthy controls (HC). MS patients were sub-grouped in active relapsing–remitting MS (aRRMS), inactive (i)RRMS, active progressive MS (aPMS) and inactive (i)PMS. Blood parameters were measured by standard laboratory methods. RESULTS: Median hepcidin levels were 26.9 ng/ml (confidence interval (CI) 22.8; 30.9) in MS and 17.3 ng/ml (CI 12.8; 23.4) in HC with significant age and sex effects. Hepcidin correlates were in line with hepcidin as an indicator of iron stores. After correction for age and sex, hepcidin was neither associated with MS subgroups nor degree of disability and occurrence of relapses. CONCLUSIONS: Serum hepcidin levels are not associated with disease activity and disease course in MS. SAGE Publications 2019-11-04 /pmc/articles/PMC6831977/ /pubmed/31723437 http://dx.doi.org/10.1177/2055217319885984 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Paper Bsteh, Gabriel Haschka, David Tymoszuk, Piotr Berek, Klaus Petzer, Verena Hegen, Harald Wurth, Sebastian Auer, Michael Zinganell, Anne Pauli, Franziska Di Deisenhammer, Florian Weiss, Guenter Berger, Thomas Serum hepcidin levels in multiple sclerosis |
title | Serum hepcidin levels in multiple sclerosis |
title_full | Serum hepcidin levels in multiple sclerosis |
title_fullStr | Serum hepcidin levels in multiple sclerosis |
title_full_unstemmed | Serum hepcidin levels in multiple sclerosis |
title_short | Serum hepcidin levels in multiple sclerosis |
title_sort | serum hepcidin levels in multiple sclerosis |
topic | Original Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831977/ https://www.ncbi.nlm.nih.gov/pubmed/31723437 http://dx.doi.org/10.1177/2055217319885984 |
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