Tyrosine Kinases in Helicobacter pylori Infections and Gastric Cancer

Helicobacter pylori (H. pylori) has been identified as a leading cause of gastric cancer, which is one of the most frequent and malignant types of tumor. It is characterized by its rapid progression, distant metastases, and resistance to conventional chemotherapy. A number of receptor tyrosine kinas...

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Autores principales: Chichirau, Bianca E., Diechler, Sebastian, Posselt, Gernot, Wessler, Silja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832112/
https://www.ncbi.nlm.nih.gov/pubmed/31614680
http://dx.doi.org/10.3390/toxins11100591
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author Chichirau, Bianca E.
Diechler, Sebastian
Posselt, Gernot
Wessler, Silja
author_facet Chichirau, Bianca E.
Diechler, Sebastian
Posselt, Gernot
Wessler, Silja
author_sort Chichirau, Bianca E.
collection PubMed
description Helicobacter pylori (H. pylori) has been identified as a leading cause of gastric cancer, which is one of the most frequent and malignant types of tumor. It is characterized by its rapid progression, distant metastases, and resistance to conventional chemotherapy. A number of receptor tyrosine kinases and non-receptor tyrosine kinases have been implicated in H. pylori-mediated pathogenesis and tumorigenesis. In this review, recent findings of deregulated EGFR, c-Met, JAK, FAK, Src, and c-Abl and their functions in H. pylori pathogenesis are summarized.
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spelling pubmed-68321122019-11-20 Tyrosine Kinases in Helicobacter pylori Infections and Gastric Cancer Chichirau, Bianca E. Diechler, Sebastian Posselt, Gernot Wessler, Silja Toxins (Basel) Review Helicobacter pylori (H. pylori) has been identified as a leading cause of gastric cancer, which is one of the most frequent and malignant types of tumor. It is characterized by its rapid progression, distant metastases, and resistance to conventional chemotherapy. A number of receptor tyrosine kinases and non-receptor tyrosine kinases have been implicated in H. pylori-mediated pathogenesis and tumorigenesis. In this review, recent findings of deregulated EGFR, c-Met, JAK, FAK, Src, and c-Abl and their functions in H. pylori pathogenesis are summarized. MDPI 2019-10-11 /pmc/articles/PMC6832112/ /pubmed/31614680 http://dx.doi.org/10.3390/toxins11100591 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chichirau, Bianca E.
Diechler, Sebastian
Posselt, Gernot
Wessler, Silja
Tyrosine Kinases in Helicobacter pylori Infections and Gastric Cancer
title Tyrosine Kinases in Helicobacter pylori Infections and Gastric Cancer
title_full Tyrosine Kinases in Helicobacter pylori Infections and Gastric Cancer
title_fullStr Tyrosine Kinases in Helicobacter pylori Infections and Gastric Cancer
title_full_unstemmed Tyrosine Kinases in Helicobacter pylori Infections and Gastric Cancer
title_short Tyrosine Kinases in Helicobacter pylori Infections and Gastric Cancer
title_sort tyrosine kinases in helicobacter pylori infections and gastric cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832112/
https://www.ncbi.nlm.nih.gov/pubmed/31614680
http://dx.doi.org/10.3390/toxins11100591
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