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Comparison of Hemodynamic Factors Predicting Prognosis in Heart Failure: A Systematic Review

Objectives: We systematically reviewed the literature to address the question of which of the three hemodynamic factors predicts prognosis best in heart failure patients when directly compared to each other: cardiac output, preload or afterload. Methods: Prognostic studies in heart failure (HF) were...

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Autores principales: Aalders, Margot, Kok, Wouter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832156/
https://www.ncbi.nlm.nih.gov/pubmed/31652650
http://dx.doi.org/10.3390/jcm8101757
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author Aalders, Margot
Kok, Wouter
author_facet Aalders, Margot
Kok, Wouter
author_sort Aalders, Margot
collection PubMed
description Objectives: We systematically reviewed the literature to address the question of which of the three hemodynamic factors predicts prognosis best in heart failure patients when directly compared to each other: cardiac output, preload or afterload. Methods: Prognostic studies in heart failure (HF) were searched that included at least two of the three hemodynamic variables: (1) cardiac output or cardiac index (CI), (2) preload represented by pulmonary capillary wedge pressure (PCWP) and (3) afterload simplified to systolic blood pressure (SBP). Critical appraisal was done according to the QUIPS format for prognostic studies. The main endpoint was all-cause mortality, which could be combined with other endpoints. We report the number of studies in which CI, PCWP and SBP remained significant prognostic predictors in multivariate analysis. We also assessed whether hemodynamic predictors of prognosis varied in four different HF-populations. Results: Included were 18 studies containing a multivariate analysis. PCWP was an independent predictor of prognosis in 10 of 18 studies, SBP in 3 of 14 studies and CI in none of 18 studies. Results were not specific for any of the HF-populations. Conclusions: A higher PCWP and lower SBP are independent predictors of poor prognosis in HF. In spite of the frequently used concept behind HF, this review demonstrates that CI is not an independent predictor of prognosis in HF.
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spelling pubmed-68321562019-11-20 Comparison of Hemodynamic Factors Predicting Prognosis in Heart Failure: A Systematic Review Aalders, Margot Kok, Wouter J Clin Med Review Objectives: We systematically reviewed the literature to address the question of which of the three hemodynamic factors predicts prognosis best in heart failure patients when directly compared to each other: cardiac output, preload or afterload. Methods: Prognostic studies in heart failure (HF) were searched that included at least two of the three hemodynamic variables: (1) cardiac output or cardiac index (CI), (2) preload represented by pulmonary capillary wedge pressure (PCWP) and (3) afterload simplified to systolic blood pressure (SBP). Critical appraisal was done according to the QUIPS format for prognostic studies. The main endpoint was all-cause mortality, which could be combined with other endpoints. We report the number of studies in which CI, PCWP and SBP remained significant prognostic predictors in multivariate analysis. We also assessed whether hemodynamic predictors of prognosis varied in four different HF-populations. Results: Included were 18 studies containing a multivariate analysis. PCWP was an independent predictor of prognosis in 10 of 18 studies, SBP in 3 of 14 studies and CI in none of 18 studies. Results were not specific for any of the HF-populations. Conclusions: A higher PCWP and lower SBP are independent predictors of poor prognosis in HF. In spite of the frequently used concept behind HF, this review demonstrates that CI is not an independent predictor of prognosis in HF. MDPI 2019-10-22 /pmc/articles/PMC6832156/ /pubmed/31652650 http://dx.doi.org/10.3390/jcm8101757 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Aalders, Margot
Kok, Wouter
Comparison of Hemodynamic Factors Predicting Prognosis in Heart Failure: A Systematic Review
title Comparison of Hemodynamic Factors Predicting Prognosis in Heart Failure: A Systematic Review
title_full Comparison of Hemodynamic Factors Predicting Prognosis in Heart Failure: A Systematic Review
title_fullStr Comparison of Hemodynamic Factors Predicting Prognosis in Heart Failure: A Systematic Review
title_full_unstemmed Comparison of Hemodynamic Factors Predicting Prognosis in Heart Failure: A Systematic Review
title_short Comparison of Hemodynamic Factors Predicting Prognosis in Heart Failure: A Systematic Review
title_sort comparison of hemodynamic factors predicting prognosis in heart failure: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832156/
https://www.ncbi.nlm.nih.gov/pubmed/31652650
http://dx.doi.org/10.3390/jcm8101757
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