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Association between Bladder Outlet Obstruction and Bladder Cancer in Patients with Aging Male

The associations between the treatment outcomes of benign prostatic hyperplasia/benign prostatic obstruction and lifelong health status, including urologic cancer incidence as well as geriatric adverse events (AEs), are unknown. This retrospective cohort study analyzed claims data collected during t...

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Autores principales: Lin, Yu-Hsiang, Hou, Chen-Pang, Juang, Horng-Heng, Chang, Phei-Lang, Chen, Tien-Hsing, Chen, Chien-Lun, Tsui, Ke-Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832159/
https://www.ncbi.nlm.nih.gov/pubmed/31569597
http://dx.doi.org/10.3390/jcm8101550
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author Lin, Yu-Hsiang
Hou, Chen-Pang
Juang, Horng-Heng
Chang, Phei-Lang
Chen, Tien-Hsing
Chen, Chien-Lun
Tsui, Ke-Hung
author_facet Lin, Yu-Hsiang
Hou, Chen-Pang
Juang, Horng-Heng
Chang, Phei-Lang
Chen, Tien-Hsing
Chen, Chien-Lun
Tsui, Ke-Hung
author_sort Lin, Yu-Hsiang
collection PubMed
description The associations between the treatment outcomes of benign prostatic hyperplasia/benign prostatic obstruction and lifelong health status, including urologic cancer incidence as well as geriatric adverse events (AEs), are unknown. This retrospective cohort study analyzed claims data collected during the period of 1997–2012 from Taiwan’s Longitudinal Health Insurance Database 2000. Patients who received transurethral resection of the prostate (TURP) were prioritized, and the remaining patients who were prescribed alpha-blockers were, subsequently, identified. Patients in the TURP and medication-only groups were further divided into two groups, according to the presence or absence of AEs during the first six-month follow-up. Outcomes of primary interest were all-cause mortality, occurrence of prostate cancer, transurethral resection of the bladder tumor, and radical cystectomy for bladder cancer. Compared with patients in the AE-free TURP group, those in the TURP with AEs had a higher risk of lifelong bladder cancer (subdistribution hazard ratio: 2.3, 95% confidence interval (CI): 1.56–3.39), whereas the risk of prostate cancer was comparable between the two groups (SHR: 1.2, 95% CI: 0.83–1.74). In the medication cohorts, patients undergoing alpha-blocker treatment who had AEs had a higher risk of all-cause mortality (hazard ratio: 1.63, 95% CI: 1.49–1.78) and a higher risk of lifelong bladder cancer (SHR: 2.72, 95% CI: 1.99–3.71) when compared with those without AE. Our study reveals that unfavorable treatment outcomes of benign prostate hyperplasia, whether caused by medication or surgical treatment, are associated with a higher incidence of bladder cancer. Unfavorable outcomes of surgical treatment are associated with higher risk of geriatric AEs, and unfavorable outcomes of medication treatment are associated with a higher risk of all-cause mortality.
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spelling pubmed-68321592019-11-20 Association between Bladder Outlet Obstruction and Bladder Cancer in Patients with Aging Male Lin, Yu-Hsiang Hou, Chen-Pang Juang, Horng-Heng Chang, Phei-Lang Chen, Tien-Hsing Chen, Chien-Lun Tsui, Ke-Hung J Clin Med Article The associations between the treatment outcomes of benign prostatic hyperplasia/benign prostatic obstruction and lifelong health status, including urologic cancer incidence as well as geriatric adverse events (AEs), are unknown. This retrospective cohort study analyzed claims data collected during the period of 1997–2012 from Taiwan’s Longitudinal Health Insurance Database 2000. Patients who received transurethral resection of the prostate (TURP) were prioritized, and the remaining patients who were prescribed alpha-blockers were, subsequently, identified. Patients in the TURP and medication-only groups were further divided into two groups, according to the presence or absence of AEs during the first six-month follow-up. Outcomes of primary interest were all-cause mortality, occurrence of prostate cancer, transurethral resection of the bladder tumor, and radical cystectomy for bladder cancer. Compared with patients in the AE-free TURP group, those in the TURP with AEs had a higher risk of lifelong bladder cancer (subdistribution hazard ratio: 2.3, 95% confidence interval (CI): 1.56–3.39), whereas the risk of prostate cancer was comparable between the two groups (SHR: 1.2, 95% CI: 0.83–1.74). In the medication cohorts, patients undergoing alpha-blocker treatment who had AEs had a higher risk of all-cause mortality (hazard ratio: 1.63, 95% CI: 1.49–1.78) and a higher risk of lifelong bladder cancer (SHR: 2.72, 95% CI: 1.99–3.71) when compared with those without AE. Our study reveals that unfavorable treatment outcomes of benign prostate hyperplasia, whether caused by medication or surgical treatment, are associated with a higher incidence of bladder cancer. Unfavorable outcomes of surgical treatment are associated with higher risk of geriatric AEs, and unfavorable outcomes of medication treatment are associated with a higher risk of all-cause mortality. MDPI 2019-09-27 /pmc/articles/PMC6832159/ /pubmed/31569597 http://dx.doi.org/10.3390/jcm8101550 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lin, Yu-Hsiang
Hou, Chen-Pang
Juang, Horng-Heng
Chang, Phei-Lang
Chen, Tien-Hsing
Chen, Chien-Lun
Tsui, Ke-Hung
Association between Bladder Outlet Obstruction and Bladder Cancer in Patients with Aging Male
title Association between Bladder Outlet Obstruction and Bladder Cancer in Patients with Aging Male
title_full Association between Bladder Outlet Obstruction and Bladder Cancer in Patients with Aging Male
title_fullStr Association between Bladder Outlet Obstruction and Bladder Cancer in Patients with Aging Male
title_full_unstemmed Association between Bladder Outlet Obstruction and Bladder Cancer in Patients with Aging Male
title_short Association between Bladder Outlet Obstruction and Bladder Cancer in Patients with Aging Male
title_sort association between bladder outlet obstruction and bladder cancer in patients with aging male
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832159/
https://www.ncbi.nlm.nih.gov/pubmed/31569597
http://dx.doi.org/10.3390/jcm8101550
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