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Association between CSF1 and CSF1R Polymorphisms and Parkinson’s Disease in Taiwan
Background: CSF1/CSF1R neuroinflammatory signaling is emerging as an important pathway involved in the pathogenesis of Parkinson’s disease (PD). However, the genetic associations between CSF1/CSF1R and PD have not yet been explored. Methods: We investigated the effects of two functional genetic vari...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832167/ https://www.ncbi.nlm.nih.gov/pubmed/31554150 http://dx.doi.org/10.3390/jcm8101529 |
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author | Chang, Kuo-Hsuan Wu, Yih-Ru Chen, Yi-Chun Wu, Hsiu-Chuan Chen, Chiung-Mei |
author_facet | Chang, Kuo-Hsuan Wu, Yih-Ru Chen, Yi-Chun Wu, Hsiu-Chuan Chen, Chiung-Mei |
author_sort | Chang, Kuo-Hsuan |
collection | PubMed |
description | Background: CSF1/CSF1R neuroinflammatory signaling is emerging as an important pathway involved in the pathogenesis of Parkinson’s disease (PD). However, the genetic associations between CSF1/CSF1R and PD have not yet been explored. Methods: We investigated the effects of two functional genetic variants, including CSF1 rs1058885 and CSF1R rs10079250 in a cohort including 502 Taiwanese patients with PD and 511 age- and gender-matched healthy controls. Results: The CSF1 rs1058885 TT genotype was less frequent in PD patients compared with control subjects (odds ratio (OR) = 0.63, 95% confidence interval (CI): 0.43–0.92, p = 0.015). The PD patients also had a lower frequency of the CSF1 rs1058885 T allele compared with the control subjects (OR = 0.80, 95% CI: 0.67–0.96, p = 0.014). No statistically significant differences in allelic and genotypic frequencies of CSF1R rs10079250 between the PD and control subjects were found, even after stratification by age at onset and gender. Conclusion: This study reports a genetic association between CSF1 and PD for the first time. |
format | Online Article Text |
id | pubmed-6832167 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-68321672019-11-20 Association between CSF1 and CSF1R Polymorphisms and Parkinson’s Disease in Taiwan Chang, Kuo-Hsuan Wu, Yih-Ru Chen, Yi-Chun Wu, Hsiu-Chuan Chen, Chiung-Mei J Clin Med Article Background: CSF1/CSF1R neuroinflammatory signaling is emerging as an important pathway involved in the pathogenesis of Parkinson’s disease (PD). However, the genetic associations between CSF1/CSF1R and PD have not yet been explored. Methods: We investigated the effects of two functional genetic variants, including CSF1 rs1058885 and CSF1R rs10079250 in a cohort including 502 Taiwanese patients with PD and 511 age- and gender-matched healthy controls. Results: The CSF1 rs1058885 TT genotype was less frequent in PD patients compared with control subjects (odds ratio (OR) = 0.63, 95% confidence interval (CI): 0.43–0.92, p = 0.015). The PD patients also had a lower frequency of the CSF1 rs1058885 T allele compared with the control subjects (OR = 0.80, 95% CI: 0.67–0.96, p = 0.014). No statistically significant differences in allelic and genotypic frequencies of CSF1R rs10079250 between the PD and control subjects were found, even after stratification by age at onset and gender. Conclusion: This study reports a genetic association between CSF1 and PD for the first time. MDPI 2019-09-24 /pmc/articles/PMC6832167/ /pubmed/31554150 http://dx.doi.org/10.3390/jcm8101529 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chang, Kuo-Hsuan Wu, Yih-Ru Chen, Yi-Chun Wu, Hsiu-Chuan Chen, Chiung-Mei Association between CSF1 and CSF1R Polymorphisms and Parkinson’s Disease in Taiwan |
title | Association between CSF1 and CSF1R Polymorphisms and Parkinson’s Disease in Taiwan |
title_full | Association between CSF1 and CSF1R Polymorphisms and Parkinson’s Disease in Taiwan |
title_fullStr | Association between CSF1 and CSF1R Polymorphisms and Parkinson’s Disease in Taiwan |
title_full_unstemmed | Association between CSF1 and CSF1R Polymorphisms and Parkinson’s Disease in Taiwan |
title_short | Association between CSF1 and CSF1R Polymorphisms and Parkinson’s Disease in Taiwan |
title_sort | association between csf1 and csf1r polymorphisms and parkinson’s disease in taiwan |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832167/ https://www.ncbi.nlm.nih.gov/pubmed/31554150 http://dx.doi.org/10.3390/jcm8101529 |
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