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Occurrence of Acute Oesophageal Necrosis (Black Oesophagus) in a Single Tertiary Centre

Acute oesophageal necrosis (AON) is a rare condition characterised by the endoscopic finding of diffuse, circumferential, black mucosal pigmentation of the oesophagus, which typically stops at the gastro-oesophageal junction. This observational study aimed to assess the occurrence, clinical characte...

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Autores principales: Davide, Orlando, Marilia, Carabotti, Maurizio, Ruggeri, Gianluca, Esposito, Domenico, Corleto Vito, Emilio, Di Giulio, Bruno, Annibale
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832419/
https://www.ncbi.nlm.nih.gov/pubmed/31554345
http://dx.doi.org/10.3390/jcm8101532
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author Davide, Orlando
Marilia, Carabotti
Maurizio, Ruggeri
Gianluca, Esposito
Domenico, Corleto Vito
Emilio, Di Giulio
Bruno, Annibale
author_facet Davide, Orlando
Marilia, Carabotti
Maurizio, Ruggeri
Gianluca, Esposito
Domenico, Corleto Vito
Emilio, Di Giulio
Bruno, Annibale
author_sort Davide, Orlando
collection PubMed
description Acute oesophageal necrosis (AON) is a rare condition characterised by the endoscopic finding of diffuse, circumferential, black mucosal pigmentation of the oesophagus, which typically stops at the gastro-oesophageal junction. This observational study aimed to assess the occurrence, clinical characteristics and outcomes of AON in a consecutive endoscopic cohort in a single tertiary university centre. A retrospective analysis of endoscopic data of upper gastrointestinal endoscopy (UGE) was carried out from 2008 to 2018. Out of 25,970 UGE, 16 patients (0.06%) had AON; 75.0% were men with a median age of 75 years. Almost all patients underwent diagnosis during emergency UGE performed for gastrointestinal bleeding, but one patient was diagnosed during elective UGE for persistent vomiting and diarrhoea. All patients reported one or more pre-existing comorbidities and concomitant acute events. Two patients had AON as the first presentation of Zollinger–Ellison syndrome (ZES). One patient developed an oesophageal stenosis, and another patient presented a relapse of AON. Mortality was 50%, but no patient died as a direct consequence of AON. AON is a rare cause of gastrointestinal bleeding diagnosed mainly during emergency UGE. Our study showed that ZES might manifest with this critical presentation, and endoscopists must be aware of this evidence.
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spelling pubmed-68324192019-11-25 Occurrence of Acute Oesophageal Necrosis (Black Oesophagus) in a Single Tertiary Centre Davide, Orlando Marilia, Carabotti Maurizio, Ruggeri Gianluca, Esposito Domenico, Corleto Vito Emilio, Di Giulio Bruno, Annibale J Clin Med Article Acute oesophageal necrosis (AON) is a rare condition characterised by the endoscopic finding of diffuse, circumferential, black mucosal pigmentation of the oesophagus, which typically stops at the gastro-oesophageal junction. This observational study aimed to assess the occurrence, clinical characteristics and outcomes of AON in a consecutive endoscopic cohort in a single tertiary university centre. A retrospective analysis of endoscopic data of upper gastrointestinal endoscopy (UGE) was carried out from 2008 to 2018. Out of 25,970 UGE, 16 patients (0.06%) had AON; 75.0% were men with a median age of 75 years. Almost all patients underwent diagnosis during emergency UGE performed for gastrointestinal bleeding, but one patient was diagnosed during elective UGE for persistent vomiting and diarrhoea. All patients reported one or more pre-existing comorbidities and concomitant acute events. Two patients had AON as the first presentation of Zollinger–Ellison syndrome (ZES). One patient developed an oesophageal stenosis, and another patient presented a relapse of AON. Mortality was 50%, but no patient died as a direct consequence of AON. AON is a rare cause of gastrointestinal bleeding diagnosed mainly during emergency UGE. Our study showed that ZES might manifest with this critical presentation, and endoscopists must be aware of this evidence. MDPI 2019-09-24 /pmc/articles/PMC6832419/ /pubmed/31554345 http://dx.doi.org/10.3390/jcm8101532 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Davide, Orlando
Marilia, Carabotti
Maurizio, Ruggeri
Gianluca, Esposito
Domenico, Corleto Vito
Emilio, Di Giulio
Bruno, Annibale
Occurrence of Acute Oesophageal Necrosis (Black Oesophagus) in a Single Tertiary Centre
title Occurrence of Acute Oesophageal Necrosis (Black Oesophagus) in a Single Tertiary Centre
title_full Occurrence of Acute Oesophageal Necrosis (Black Oesophagus) in a Single Tertiary Centre
title_fullStr Occurrence of Acute Oesophageal Necrosis (Black Oesophagus) in a Single Tertiary Centre
title_full_unstemmed Occurrence of Acute Oesophageal Necrosis (Black Oesophagus) in a Single Tertiary Centre
title_short Occurrence of Acute Oesophageal Necrosis (Black Oesophagus) in a Single Tertiary Centre
title_sort occurrence of acute oesophageal necrosis (black oesophagus) in a single tertiary centre
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832419/
https://www.ncbi.nlm.nih.gov/pubmed/31554345
http://dx.doi.org/10.3390/jcm8101532
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