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Differential Pathogenicity of SHIV KB9 and 89.6 Env Correlates with Bystander Apoptosis Induction in CD4+ T cells

SHIV variants KB9 and 89.6 show differential pathogenesis in primate models with KB9 causing rapid CD4 decline while 89.6 failing to induce disease. We attempted to determine whether the differential pathogenicity of KB9 versus 89.6 was a result of differential bystander apoptosis inducing potential...

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Detalles Bibliográficos
Autores principales: Mehmetoglu-Gurbuz, Tugba, Joshi, Anjali, Garg, Himanshu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832477/
https://www.ncbi.nlm.nih.gov/pubmed/31581579
http://dx.doi.org/10.3390/v11100911

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