Cargando…
Native Nephrectomy before and after Renal Transplantation in Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD)
The aim of this study was 1) to evaluate and compare pre-, peri-, and post-operative data of Autosomal Dominant Polycystic Kidney Disease (ADPKD) patients undergoing native nephrectomy (NN) either before or after renal transplantation and 2) to identify advantages of optimal surgical timing, postope...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832478/ https://www.ncbi.nlm.nih.gov/pubmed/31590248 http://dx.doi.org/10.3390/jcm8101622 |
_version_ | 1783466182079152128 |
---|---|
author | Maxeiner, Andreas Bichmann, Anna Oberländer, Natalie El-Bandar, Nasrin Sugünes, Nesrin Ralla, Bernhard Biernath, Nadine Liefeldt, Lutz Budde, Klemens Giessing, Markus Schlomm, Thorsten Friedersdorff, Frank |
author_facet | Maxeiner, Andreas Bichmann, Anna Oberländer, Natalie El-Bandar, Nasrin Sugünes, Nesrin Ralla, Bernhard Biernath, Nadine Liefeldt, Lutz Budde, Klemens Giessing, Markus Schlomm, Thorsten Friedersdorff, Frank |
author_sort | Maxeiner, Andreas |
collection | PubMed |
description | The aim of this study was 1) to evaluate and compare pre-, peri-, and post-operative data of Autosomal Dominant Polycystic Kidney Disease (ADPKD) patients undergoing native nephrectomy (NN) either before or after renal transplantation and 2) to identify advantages of optimal surgical timing, postoperative outcomes, and economical aspects in a tertiary transplant centre. This retrospective analysis included 121 patients divided into two groups—group 1: patients who underwent NN prior to receiving a kidney transplant (n = 89) and group 2: patients who underwent NN post-transplant (n = 32). Data analysis was performed according to demographic patient details, surgical indication, laboratory parameters, perioperative complications, underlying pathology, and associated mortality. There was no significant difference in patient demographics between the groups, however right-sided nephrectomy was performed predominantly within group 1. The main indication in both groups undergoing a nephrectomy was pain. Patients among group 2 had no postoperative kidney failure and a significantly shorter hospital stay. Higher rates of more severe complications were observed in group 1, even though this was not statistically significant. Even though the differences between both groups were substantial, the time of NN prior or post-transplant does not seem to affect short-term and long-term transplantation outcomes. Retroperitoneal NN remains a low risk treatment option in patients with symptomatic ADPKD and can be performed either pre- or post-kidney transplantation depending on patients’ symptom severity. |
format | Online Article Text |
id | pubmed-6832478 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-68324782019-11-25 Native Nephrectomy before and after Renal Transplantation in Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) Maxeiner, Andreas Bichmann, Anna Oberländer, Natalie El-Bandar, Nasrin Sugünes, Nesrin Ralla, Bernhard Biernath, Nadine Liefeldt, Lutz Budde, Klemens Giessing, Markus Schlomm, Thorsten Friedersdorff, Frank J Clin Med Article The aim of this study was 1) to evaluate and compare pre-, peri-, and post-operative data of Autosomal Dominant Polycystic Kidney Disease (ADPKD) patients undergoing native nephrectomy (NN) either before or after renal transplantation and 2) to identify advantages of optimal surgical timing, postoperative outcomes, and economical aspects in a tertiary transplant centre. This retrospective analysis included 121 patients divided into two groups—group 1: patients who underwent NN prior to receiving a kidney transplant (n = 89) and group 2: patients who underwent NN post-transplant (n = 32). Data analysis was performed according to demographic patient details, surgical indication, laboratory parameters, perioperative complications, underlying pathology, and associated mortality. There was no significant difference in patient demographics between the groups, however right-sided nephrectomy was performed predominantly within group 1. The main indication in both groups undergoing a nephrectomy was pain. Patients among group 2 had no postoperative kidney failure and a significantly shorter hospital stay. Higher rates of more severe complications were observed in group 1, even though this was not statistically significant. Even though the differences between both groups were substantial, the time of NN prior or post-transplant does not seem to affect short-term and long-term transplantation outcomes. Retroperitoneal NN remains a low risk treatment option in patients with symptomatic ADPKD and can be performed either pre- or post-kidney transplantation depending on patients’ symptom severity. MDPI 2019-10-04 /pmc/articles/PMC6832478/ /pubmed/31590248 http://dx.doi.org/10.3390/jcm8101622 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Maxeiner, Andreas Bichmann, Anna Oberländer, Natalie El-Bandar, Nasrin Sugünes, Nesrin Ralla, Bernhard Biernath, Nadine Liefeldt, Lutz Budde, Klemens Giessing, Markus Schlomm, Thorsten Friedersdorff, Frank Native Nephrectomy before and after Renal Transplantation in Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) |
title | Native Nephrectomy before and after Renal Transplantation in Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) |
title_full | Native Nephrectomy before and after Renal Transplantation in Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) |
title_fullStr | Native Nephrectomy before and after Renal Transplantation in Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) |
title_full_unstemmed | Native Nephrectomy before and after Renal Transplantation in Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) |
title_short | Native Nephrectomy before and after Renal Transplantation in Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) |
title_sort | native nephrectomy before and after renal transplantation in patients with autosomal dominant polycystic kidney disease (adpkd) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832478/ https://www.ncbi.nlm.nih.gov/pubmed/31590248 http://dx.doi.org/10.3390/jcm8101622 |
work_keys_str_mv | AT maxeinerandreas nativenephrectomybeforeandafterrenaltransplantationinpatientswithautosomaldominantpolycystickidneydiseaseadpkd AT bichmannanna nativenephrectomybeforeandafterrenaltransplantationinpatientswithautosomaldominantpolycystickidneydiseaseadpkd AT oberlandernatalie nativenephrectomybeforeandafterrenaltransplantationinpatientswithautosomaldominantpolycystickidneydiseaseadpkd AT elbandarnasrin nativenephrectomybeforeandafterrenaltransplantationinpatientswithautosomaldominantpolycystickidneydiseaseadpkd AT sugunesnesrin nativenephrectomybeforeandafterrenaltransplantationinpatientswithautosomaldominantpolycystickidneydiseaseadpkd AT rallabernhard nativenephrectomybeforeandafterrenaltransplantationinpatientswithautosomaldominantpolycystickidneydiseaseadpkd AT biernathnadine nativenephrectomybeforeandafterrenaltransplantationinpatientswithautosomaldominantpolycystickidneydiseaseadpkd AT liefeldtlutz nativenephrectomybeforeandafterrenaltransplantationinpatientswithautosomaldominantpolycystickidneydiseaseadpkd AT buddeklemens nativenephrectomybeforeandafterrenaltransplantationinpatientswithautosomaldominantpolycystickidneydiseaseadpkd AT giessingmarkus nativenephrectomybeforeandafterrenaltransplantationinpatientswithautosomaldominantpolycystickidneydiseaseadpkd AT schlommthorsten nativenephrectomybeforeandafterrenaltransplantationinpatientswithautosomaldominantpolycystickidneydiseaseadpkd AT friedersdorfffrank nativenephrectomybeforeandafterrenaltransplantationinpatientswithautosomaldominantpolycystickidneydiseaseadpkd |