GSKIP-Mediated Anchoring Increases Phosphorylation of Tau by PKA but Not by GSK3beta via cAMP/PKA/GSKIP/GSK3/Tau Axis Signaling in Cerebrospinal Fluid and iPS Cells in Alzheimer Disease

Based on the protein kinase A (PKA)/GSK3β interaction protein (GSKIP)/glycogen synthase kinase 3β (GSK3β) axis, we hypothesized that these might play a role in Tau phosphorylation. Here, we report that the phosphorylation of Tau Ser409 in SHSY5Y cells was increased by overexpression of GSKIP WT more...

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Detalles Bibliográficos
Autores principales: Ko, Huey-Jiun, Chiou, Shean-Jaw, Wong, Yu-Hui, Wang, Yin-Hsuan, Lai, Yun-Ling, Chou, Chia-Hua, Wang, Chihuei, Loh, Joon-Khim, Lieu, Ann-Shung, Cheng, Jiin-Tsuey, Lin, Yu-Te, Lu, Pei-Jung, Fann, Ming-Ji, Huang, Chi-Ying, Hong, Yi-Ren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832502/
https://www.ncbi.nlm.nih.gov/pubmed/31640277
http://dx.doi.org/10.3390/jcm8101751

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