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Sensitivity and Specificity of Ultrawide-Field Fundus Photography for the Staging of Sickle Cell Retinopathy in Real-Life Practice at Varying Expertise Level

Purpose: To evaluate the sensitivity and specificity of ultrawide-field fundus photography (UWF-FP) for the detection and classification of sickle cell retinopathy (SCR) by ophthalmologists with varying degrees of expertise in retinal disease. Methods: Patients presenting with sickle cell disease (S...

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Autores principales: Bunod, Roxane, Mouallem-Beziere, Alexandra, Amoroso, Francesca, Capuano, Vittorio, Bitton, Karen, Kamami-Levy, Cynthia, Jung, Camille, Souied, Eric H., Miere, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832510/
https://www.ncbi.nlm.nih.gov/pubmed/31614597
http://dx.doi.org/10.3390/jcm8101660
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author Bunod, Roxane
Mouallem-Beziere, Alexandra
Amoroso, Francesca
Capuano, Vittorio
Bitton, Karen
Kamami-Levy, Cynthia
Jung, Camille
Souied, Eric H.
Miere, Alexandra
author_facet Bunod, Roxane
Mouallem-Beziere, Alexandra
Amoroso, Francesca
Capuano, Vittorio
Bitton, Karen
Kamami-Levy, Cynthia
Jung, Camille
Souied, Eric H.
Miere, Alexandra
author_sort Bunod, Roxane
collection PubMed
description Purpose: To evaluate the sensitivity and specificity of ultrawide-field fundus photography (UWF-FP) for the detection and classification of sickle cell retinopathy (SCR) by ophthalmologists with varying degrees of expertise in retinal disease. Methods: Patients presenting with sickle cell disease (SCD) in the Créteil University Eye Clinic, having undergone UWF-FP and ultrawide-field fluorescein angiography (UWF-FA) on the same day, were retrospectively included. Eyes with previous retinal photocoagulation were excluded. SCR was graded independently by UWF-FP and UWF-FA using Goldberg classification by two ophthalmologists with varying expertise levels. Results: Sixty-six eyes of 33 patients were included in the study. The sensitivity of UWF-FP for the detection of proliferative SCR was 100%, (95% confidence interval [CI95%] 76.8–100) for the retinal specialist and 100% (CI95% 71.5–100) for the ophthalmology resident. The specificity of UWF-FP for the detection of proliferative SCR was 100% (CI95% 92.7–100) for the retinal specialist and 98.1% (CI95% 89.7–100) for the ophthalmology resident. Conclusions: UWF-FP is a valuable exam for proliferative SCR screening, with excellent sensitivity and specificity and a good inter-grader agreement for ophthalmologists with various degree of skills, and is easy to use in a real-life setting.
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spelling pubmed-68325102019-11-25 Sensitivity and Specificity of Ultrawide-Field Fundus Photography for the Staging of Sickle Cell Retinopathy in Real-Life Practice at Varying Expertise Level Bunod, Roxane Mouallem-Beziere, Alexandra Amoroso, Francesca Capuano, Vittorio Bitton, Karen Kamami-Levy, Cynthia Jung, Camille Souied, Eric H. Miere, Alexandra J Clin Med Article Purpose: To evaluate the sensitivity and specificity of ultrawide-field fundus photography (UWF-FP) for the detection and classification of sickle cell retinopathy (SCR) by ophthalmologists with varying degrees of expertise in retinal disease. Methods: Patients presenting with sickle cell disease (SCD) in the Créteil University Eye Clinic, having undergone UWF-FP and ultrawide-field fluorescein angiography (UWF-FA) on the same day, were retrospectively included. Eyes with previous retinal photocoagulation were excluded. SCR was graded independently by UWF-FP and UWF-FA using Goldberg classification by two ophthalmologists with varying expertise levels. Results: Sixty-six eyes of 33 patients were included in the study. The sensitivity of UWF-FP for the detection of proliferative SCR was 100%, (95% confidence interval [CI95%] 76.8–100) for the retinal specialist and 100% (CI95% 71.5–100) for the ophthalmology resident. The specificity of UWF-FP for the detection of proliferative SCR was 100% (CI95% 92.7–100) for the retinal specialist and 98.1% (CI95% 89.7–100) for the ophthalmology resident. Conclusions: UWF-FP is a valuable exam for proliferative SCR screening, with excellent sensitivity and specificity and a good inter-grader agreement for ophthalmologists with various degree of skills, and is easy to use in a real-life setting. MDPI 2019-10-11 /pmc/articles/PMC6832510/ /pubmed/31614597 http://dx.doi.org/10.3390/jcm8101660 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bunod, Roxane
Mouallem-Beziere, Alexandra
Amoroso, Francesca
Capuano, Vittorio
Bitton, Karen
Kamami-Levy, Cynthia
Jung, Camille
Souied, Eric H.
Miere, Alexandra
Sensitivity and Specificity of Ultrawide-Field Fundus Photography for the Staging of Sickle Cell Retinopathy in Real-Life Practice at Varying Expertise Level
title Sensitivity and Specificity of Ultrawide-Field Fundus Photography for the Staging of Sickle Cell Retinopathy in Real-Life Practice at Varying Expertise Level
title_full Sensitivity and Specificity of Ultrawide-Field Fundus Photography for the Staging of Sickle Cell Retinopathy in Real-Life Practice at Varying Expertise Level
title_fullStr Sensitivity and Specificity of Ultrawide-Field Fundus Photography for the Staging of Sickle Cell Retinopathy in Real-Life Practice at Varying Expertise Level
title_full_unstemmed Sensitivity and Specificity of Ultrawide-Field Fundus Photography for the Staging of Sickle Cell Retinopathy in Real-Life Practice at Varying Expertise Level
title_short Sensitivity and Specificity of Ultrawide-Field Fundus Photography for the Staging of Sickle Cell Retinopathy in Real-Life Practice at Varying Expertise Level
title_sort sensitivity and specificity of ultrawide-field fundus photography for the staging of sickle cell retinopathy in real-life practice at varying expertise level
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832510/
https://www.ncbi.nlm.nih.gov/pubmed/31614597
http://dx.doi.org/10.3390/jcm8101660
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