Immunological Effects and Viral Gene Expression Determine the Efficacy of Oncolytic Measles Vaccines Encoding IL-12 or IL-15 Agonists

Tumor-targeted immunomodulation using oncolytic viral vectors is currently being investigated as a promising strategy in cancer therapy. In a previous study, we showed that a measles virus Schwarz vaccine strain (MeVac) vector encoding an interleukin-12 fusion protein (FmIL-12) is an effective immun...

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Detalles Bibliográficos
Autores principales: Backhaus, Paul S., Veinalde, Rūta, Hartmann, Laura, Dunder, Jessica E., Jeworowski, Lara M., Albert, Jessica, Hoyler, Birgit, Poth, Tanja, Jäger, Dirk, Ungerechts, Guy, Engeland, Christine E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832518/
https://www.ncbi.nlm.nih.gov/pubmed/31623390
http://dx.doi.org/10.3390/v11100914

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832518/
https://www.ncbi.nlm.nih.gov/pubmed/31623390
http://dx.doi.org/10.3390/v11100914

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