Phenotypic Switching of Naïve T Cells to Immune-Suppressive Treg-Like Cells by Mutant KRAS

Oncogenic (mutant) Ras protein Kirsten rat sarcoma viral oncogene homolog (KRAS) promotes uncontrolled proliferation, altered metabolism, and loss of genome integrity in a cell-intrinsic manner. Here, we demonstrate that CD4(+) T cells when incubated with tumor-derived exosomes from mutant (MT) KRAS...

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Detalles Bibliográficos
Autores principales: Kalvala, Arjun, Wallet, Pierre, Yang, Lu, Wang, Chongkai, Li, Haiqing, Nam, Arin, Nathan, Anusha, Mambetsariev, Isa, Poroyko, Valeriy, Gao, Hanlin, Chu, Peiguo, Sattler, Martin, Bild, Andrea, Manuel, Edwin R., Lee, Peter P., Jolly, Mohit Kumar, Kulkarni, Prakash, Salgia, Ravi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832522/
https://www.ncbi.nlm.nih.gov/pubmed/31635338
http://dx.doi.org/10.3390/jcm8101726

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832522/
https://www.ncbi.nlm.nih.gov/pubmed/31635338
http://dx.doi.org/10.3390/jcm8101726

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