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Iron Deficiency in Acute Decompensated Heart Failure

The aim of this study was to characterize iron deficiency (ID) in acutely decompensated heart failure (ADHF) and identify whether ID is associated with dyspnea class, length of stay (LOS), biomarker levels, and echocardiographic indices of diastolic function in patients with reduced ejection fractio...

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Autores principales: Beale, Anna, Carballo, David, Stirnemann, Jerome, Garin, Nicolas, Agoritsas, Thomas, Serratrice, Jacques, Kaye, David, Meyer, Philippe, Carballo, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832529/
https://www.ncbi.nlm.nih.gov/pubmed/31581494
http://dx.doi.org/10.3390/jcm8101569
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author Beale, Anna
Carballo, David
Stirnemann, Jerome
Garin, Nicolas
Agoritsas, Thomas
Serratrice, Jacques
Kaye, David
Meyer, Philippe
Carballo, Sebastian
author_facet Beale, Anna
Carballo, David
Stirnemann, Jerome
Garin, Nicolas
Agoritsas, Thomas
Serratrice, Jacques
Kaye, David
Meyer, Philippe
Carballo, Sebastian
author_sort Beale, Anna
collection PubMed
description The aim of this study was to characterize iron deficiency (ID) in acutely decompensated heart failure (ADHF) and identify whether ID is associated with dyspnea class, length of stay (LOS), biomarker levels, and echocardiographic indices of diastolic function in patients with reduced ejection fraction (HFrEF) and with preserved ejection fraction (HFpEF). Consecutive patients admitted with ADHF at a single tertiary center were included. Demographic information, pathology investigations, and metrics regarding hospital stay and readmission were recorded. Patients were classified as having ‘absolute’ ID if they had a ferritin level <100 ng/mL; or ‘functional’ ID if they had a ferritin 100–200 ng/mL and a transferrin saturation <20%. Of 503 patients that were recruited, 270 (55%) had HFpEF, 160 (33%) had HFREF, and 57 (12%) had heart failure with mid-range ejection fraction. ID was present in 54% of patients with HFrEF and 56% of patients with HFpEF. In the HFpEF group, ID was associated with a LOS of 11 ± 7.7 vs. 9 ± 6 days in iron replete patients, p = 0.036, and remained an independent predictor of increased LOS in a multivariate linear regression incorporating comorbidities, age, and ID status. This study corroborates a high prevalence of ID in both HFrEF and HFpEF, and further shows that in patients with HFpEF there is a prolongation of LOS not seen in HFrEF which may indicate a more prominent role for ID in HFpEF.
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spelling pubmed-68325292019-11-25 Iron Deficiency in Acute Decompensated Heart Failure Beale, Anna Carballo, David Stirnemann, Jerome Garin, Nicolas Agoritsas, Thomas Serratrice, Jacques Kaye, David Meyer, Philippe Carballo, Sebastian J Clin Med Article The aim of this study was to characterize iron deficiency (ID) in acutely decompensated heart failure (ADHF) and identify whether ID is associated with dyspnea class, length of stay (LOS), biomarker levels, and echocardiographic indices of diastolic function in patients with reduced ejection fraction (HFrEF) and with preserved ejection fraction (HFpEF). Consecutive patients admitted with ADHF at a single tertiary center were included. Demographic information, pathology investigations, and metrics regarding hospital stay and readmission were recorded. Patients were classified as having ‘absolute’ ID if they had a ferritin level <100 ng/mL; or ‘functional’ ID if they had a ferritin 100–200 ng/mL and a transferrin saturation <20%. Of 503 patients that were recruited, 270 (55%) had HFpEF, 160 (33%) had HFREF, and 57 (12%) had heart failure with mid-range ejection fraction. ID was present in 54% of patients with HFrEF and 56% of patients with HFpEF. In the HFpEF group, ID was associated with a LOS of 11 ± 7.7 vs. 9 ± 6 days in iron replete patients, p = 0.036, and remained an independent predictor of increased LOS in a multivariate linear regression incorporating comorbidities, age, and ID status. This study corroborates a high prevalence of ID in both HFrEF and HFpEF, and further shows that in patients with HFpEF there is a prolongation of LOS not seen in HFrEF which may indicate a more prominent role for ID in HFpEF. MDPI 2019-10-01 /pmc/articles/PMC6832529/ /pubmed/31581494 http://dx.doi.org/10.3390/jcm8101569 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Beale, Anna
Carballo, David
Stirnemann, Jerome
Garin, Nicolas
Agoritsas, Thomas
Serratrice, Jacques
Kaye, David
Meyer, Philippe
Carballo, Sebastian
Iron Deficiency in Acute Decompensated Heart Failure
title Iron Deficiency in Acute Decompensated Heart Failure
title_full Iron Deficiency in Acute Decompensated Heart Failure
title_fullStr Iron Deficiency in Acute Decompensated Heart Failure
title_full_unstemmed Iron Deficiency in Acute Decompensated Heart Failure
title_short Iron Deficiency in Acute Decompensated Heart Failure
title_sort iron deficiency in acute decompensated heart failure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832529/
https://www.ncbi.nlm.nih.gov/pubmed/31581494
http://dx.doi.org/10.3390/jcm8101569
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