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One-Pot Two-Step Synthesis of 2-Aryl benzimidazole N-oxides Using Microwave Heating as a Tool
A methodology is reported for the preparation of 2-aryl-benzimidazole-3-oxide derivatives. By means of a one-pot two-step protocol, a library of 42 new compounds has been prepared. Reactions were performed in a total time of 40 min using microwave heating as a tool. A streamlined work-up process was...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832536/ https://www.ncbi.nlm.nih.gov/pubmed/31600970 http://dx.doi.org/10.3390/molecules24203639 |
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author | Politano, Fabrizio Gran-Magano, Ana K. Leadbeater, Nicholas E. |
author_facet | Politano, Fabrizio Gran-Magano, Ana K. Leadbeater, Nicholas E. |
author_sort | Politano, Fabrizio |
collection | PubMed |
description | A methodology is reported for the preparation of 2-aryl-benzimidazole-3-oxide derivatives. By means of a one-pot two-step protocol, a library of 42 new compounds has been prepared. Reactions were performed in a total time of 40 min using microwave heating as a tool. A streamlined work-up process was also developed, allowing for facile isolation of the products. The methodology offers a more sustainable approach than previous routes, with only water and ethanol being used as solvents, and the products being isolated by means of a simple filtration without the need for any further purification. |
format | Online Article Text |
id | pubmed-6832536 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-68325362019-11-25 One-Pot Two-Step Synthesis of 2-Aryl benzimidazole N-oxides Using Microwave Heating as a Tool Politano, Fabrizio Gran-Magano, Ana K. Leadbeater, Nicholas E. Molecules Article A methodology is reported for the preparation of 2-aryl-benzimidazole-3-oxide derivatives. By means of a one-pot two-step protocol, a library of 42 new compounds has been prepared. Reactions were performed in a total time of 40 min using microwave heating as a tool. A streamlined work-up process was also developed, allowing for facile isolation of the products. The methodology offers a more sustainable approach than previous routes, with only water and ethanol being used as solvents, and the products being isolated by means of a simple filtration without the need for any further purification. MDPI 2019-10-09 /pmc/articles/PMC6832536/ /pubmed/31600970 http://dx.doi.org/10.3390/molecules24203639 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Politano, Fabrizio Gran-Magano, Ana K. Leadbeater, Nicholas E. One-Pot Two-Step Synthesis of 2-Aryl benzimidazole N-oxides Using Microwave Heating as a Tool |
title | One-Pot Two-Step Synthesis of 2-Aryl benzimidazole N-oxides Using Microwave Heating as a Tool |
title_full | One-Pot Two-Step Synthesis of 2-Aryl benzimidazole N-oxides Using Microwave Heating as a Tool |
title_fullStr | One-Pot Two-Step Synthesis of 2-Aryl benzimidazole N-oxides Using Microwave Heating as a Tool |
title_full_unstemmed | One-Pot Two-Step Synthesis of 2-Aryl benzimidazole N-oxides Using Microwave Heating as a Tool |
title_short | One-Pot Two-Step Synthesis of 2-Aryl benzimidazole N-oxides Using Microwave Heating as a Tool |
title_sort | one-pot two-step synthesis of 2-aryl benzimidazole n-oxides using microwave heating as a tool |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832536/ https://www.ncbi.nlm.nih.gov/pubmed/31600970 http://dx.doi.org/10.3390/molecules24203639 |
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