One-Pot Two-Step Synthesis of 2-Aryl benzimidazole N-oxides Using Microwave Heating as a Tool

A methodology is reported for the preparation of 2-aryl-benzimidazole-3-oxide derivatives. By means of a one-pot two-step protocol, a library of 42 new compounds has been prepared. Reactions were performed in a total time of 40 min using microwave heating as a tool. A streamlined work-up process was...

Descripción completa

Detalles Bibliográficos
Autores principales: Politano, Fabrizio, Gran-Magano, Ana K., Leadbeater, Nicholas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832536/
https://www.ncbi.nlm.nih.gov/pubmed/31600970
http://dx.doi.org/10.3390/molecules24203639
_version_ 1783466196064010240
author Politano, Fabrizio
Gran-Magano, Ana K.
Leadbeater, Nicholas E.
author_facet Politano, Fabrizio
Gran-Magano, Ana K.
Leadbeater, Nicholas E.
author_sort Politano, Fabrizio
collection PubMed
description A methodology is reported for the preparation of 2-aryl-benzimidazole-3-oxide derivatives. By means of a one-pot two-step protocol, a library of 42 new compounds has been prepared. Reactions were performed in a total time of 40 min using microwave heating as a tool. A streamlined work-up process was also developed, allowing for facile isolation of the products. The methodology offers a more sustainable approach than previous routes, with only water and ethanol being used as solvents, and the products being isolated by means of a simple filtration without the need for any further purification.
format Online
Article
Text
id pubmed-6832536
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-68325362019-11-25 One-Pot Two-Step Synthesis of 2-Aryl benzimidazole N-oxides Using Microwave Heating as a Tool Politano, Fabrizio Gran-Magano, Ana K. Leadbeater, Nicholas E. Molecules Article A methodology is reported for the preparation of 2-aryl-benzimidazole-3-oxide derivatives. By means of a one-pot two-step protocol, a library of 42 new compounds has been prepared. Reactions were performed in a total time of 40 min using microwave heating as a tool. A streamlined work-up process was also developed, allowing for facile isolation of the products. The methodology offers a more sustainable approach than previous routes, with only water and ethanol being used as solvents, and the products being isolated by means of a simple filtration without the need for any further purification. MDPI 2019-10-09 /pmc/articles/PMC6832536/ /pubmed/31600970 http://dx.doi.org/10.3390/molecules24203639 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Politano, Fabrizio
Gran-Magano, Ana K.
Leadbeater, Nicholas E.
One-Pot Two-Step Synthesis of 2-Aryl benzimidazole N-oxides Using Microwave Heating as a Tool
title One-Pot Two-Step Synthesis of 2-Aryl benzimidazole N-oxides Using Microwave Heating as a Tool
title_full One-Pot Two-Step Synthesis of 2-Aryl benzimidazole N-oxides Using Microwave Heating as a Tool
title_fullStr One-Pot Two-Step Synthesis of 2-Aryl benzimidazole N-oxides Using Microwave Heating as a Tool
title_full_unstemmed One-Pot Two-Step Synthesis of 2-Aryl benzimidazole N-oxides Using Microwave Heating as a Tool
title_short One-Pot Two-Step Synthesis of 2-Aryl benzimidazole N-oxides Using Microwave Heating as a Tool
title_sort one-pot two-step synthesis of 2-aryl benzimidazole n-oxides using microwave heating as a tool
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832536/
https://www.ncbi.nlm.nih.gov/pubmed/31600970
http://dx.doi.org/10.3390/molecules24203639
work_keys_str_mv AT politanofabrizio onepottwostepsynthesisof2arylbenzimidazolenoxidesusingmicrowaveheatingasatool
AT granmaganoanak onepottwostepsynthesisof2arylbenzimidazolenoxidesusingmicrowaveheatingasatool
AT leadbeaternicholase onepottwostepsynthesisof2arylbenzimidazolenoxidesusingmicrowaveheatingasatool

Ejemplares similares