Cargando…
Preeclampsia: Risk Factors, Diagnosis, Management, and the Cardiovascular Impact on the Offspring
Hypertensive disorders of pregnancy affect up to 10% of pregnancies worldwide, which includes the 3%–5% of all pregnancies complicated by preeclampsia. Preeclampsia is defined as new onset hypertension after 20 weeks’ gestation with evidence of maternal organ or uteroplacental dysfunction or protein...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832549/ https://www.ncbi.nlm.nih.gov/pubmed/31590294 http://dx.doi.org/10.3390/jcm8101625 |
_version_ | 1783466199124803584 |
---|---|
author | Fox, Rachael Kitt, Jamie Leeson, Paul Aye, Christina Y.L. Lewandowski, Adam J. |
author_facet | Fox, Rachael Kitt, Jamie Leeson, Paul Aye, Christina Y.L. Lewandowski, Adam J. |
author_sort | Fox, Rachael |
collection | PubMed |
description | Hypertensive disorders of pregnancy affect up to 10% of pregnancies worldwide, which includes the 3%–5% of all pregnancies complicated by preeclampsia. Preeclampsia is defined as new onset hypertension after 20 weeks’ gestation with evidence of maternal organ or uteroplacental dysfunction or proteinuria. Despite its prevalence, the risk factors that have been identified lack accuracy in predicting its onset and preventative therapies only moderately reduce a woman’s risk of preeclampsia. Preeclampsia is a major cause of maternal morbidity and is associated with adverse foetal outcomes including intra-uterine growth restriction, preterm birth, placental abruption, foetal distress, and foetal death in utero. At present, national guidelines for foetal surveillance in preeclamptic pregnancies are inconsistent, due to a lack of evidence detailing the most appropriate assessment modalities as well as the timing and frequency at which assessments should be conducted. Current management of the foetus in preeclampsia involves timely delivery and prevention of adverse effects of prematurity with antenatal corticosteroids and/or magnesium sulphate depending on gestation. Alongside the risks to the foetus during pregnancy, there is also growing evidence that preeclampsia has long-term adverse effects on the offspring. In particular, preeclampsia has been associated with cardiovascular sequelae in the offspring including hypertension and altered vascular function. |
format | Online Article Text |
id | pubmed-6832549 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-68325492019-11-25 Preeclampsia: Risk Factors, Diagnosis, Management, and the Cardiovascular Impact on the Offspring Fox, Rachael Kitt, Jamie Leeson, Paul Aye, Christina Y.L. Lewandowski, Adam J. J Clin Med Review Hypertensive disorders of pregnancy affect up to 10% of pregnancies worldwide, which includes the 3%–5% of all pregnancies complicated by preeclampsia. Preeclampsia is defined as new onset hypertension after 20 weeks’ gestation with evidence of maternal organ or uteroplacental dysfunction or proteinuria. Despite its prevalence, the risk factors that have been identified lack accuracy in predicting its onset and preventative therapies only moderately reduce a woman’s risk of preeclampsia. Preeclampsia is a major cause of maternal morbidity and is associated with adverse foetal outcomes including intra-uterine growth restriction, preterm birth, placental abruption, foetal distress, and foetal death in utero. At present, national guidelines for foetal surveillance in preeclamptic pregnancies are inconsistent, due to a lack of evidence detailing the most appropriate assessment modalities as well as the timing and frequency at which assessments should be conducted. Current management of the foetus in preeclampsia involves timely delivery and prevention of adverse effects of prematurity with antenatal corticosteroids and/or magnesium sulphate depending on gestation. Alongside the risks to the foetus during pregnancy, there is also growing evidence that preeclampsia has long-term adverse effects on the offspring. In particular, preeclampsia has been associated with cardiovascular sequelae in the offspring including hypertension and altered vascular function. MDPI 2019-10-04 /pmc/articles/PMC6832549/ /pubmed/31590294 http://dx.doi.org/10.3390/jcm8101625 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Fox, Rachael Kitt, Jamie Leeson, Paul Aye, Christina Y.L. Lewandowski, Adam J. Preeclampsia: Risk Factors, Diagnosis, Management, and the Cardiovascular Impact on the Offspring |
title | Preeclampsia: Risk Factors, Diagnosis, Management, and the Cardiovascular Impact on the Offspring |
title_full | Preeclampsia: Risk Factors, Diagnosis, Management, and the Cardiovascular Impact on the Offspring |
title_fullStr | Preeclampsia: Risk Factors, Diagnosis, Management, and the Cardiovascular Impact on the Offspring |
title_full_unstemmed | Preeclampsia: Risk Factors, Diagnosis, Management, and the Cardiovascular Impact on the Offspring |
title_short | Preeclampsia: Risk Factors, Diagnosis, Management, and the Cardiovascular Impact on the Offspring |
title_sort | preeclampsia: risk factors, diagnosis, management, and the cardiovascular impact on the offspring |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832549/ https://www.ncbi.nlm.nih.gov/pubmed/31590294 http://dx.doi.org/10.3390/jcm8101625 |
work_keys_str_mv | AT foxrachael preeclampsiariskfactorsdiagnosismanagementandthecardiovascularimpactontheoffspring AT kittjamie preeclampsiariskfactorsdiagnosismanagementandthecardiovascularimpactontheoffspring AT leesonpaul preeclampsiariskfactorsdiagnosismanagementandthecardiovascularimpactontheoffspring AT ayechristinayl preeclampsiariskfactorsdiagnosismanagementandthecardiovascularimpactontheoffspring AT lewandowskiadamj preeclampsiariskfactorsdiagnosismanagementandthecardiovascularimpactontheoffspring |