Cargando…

Embelin as a Novel Inhibitor of PKC in the Prevention of Platelet Activation and Thrombus Formation

Embelin is a quinone derivative and found in the fruits of Embelia ribes Burm.f. Embelin has been identified as a small molecular inhibitor of X-chromosome-linked inhibitor of apoptosis proteins, and has multiple biological activities, including antioxidation, anti-inflammation, and antitumor effect...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Jiun Yi, Chen, Ray Jade, Huang, Li Ting, Lee, Tzu Yin, Lu, Wan Jung, Lin, Kuan Hung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832570/ https://www.ncbi.nlm.nih.gov/pubmed/31635287 http://dx.doi.org/10.3390/jcm8101724

Ejemplares similares

VAS2870 and VAS3947 attenuate platelet activation and thrombus formation via a NOX-independent pathway downstream of PKC
por: Lu, Wan Jung, et al.
Publicado: (2019)

Licochalcone A Prevents Platelet Activation and Thrombus Formation through the Inhibition of PLCγ2-PKC, Akt, and MAPK Pathways
por: Lien, Li-Ming, et al.
Publicado: (2017)

Phospholipase D1 and D2 Synergistically Regulate Thrombus Formation
por: Lien, Li-Ming, et al.
Publicado: (2020)

A novel naphthalimide derivative reduces platelet activation and thrombus formation via suppressing GPVI
por: Shih, Tzenge‐Lien, et al.
Publicado: (2021)

Functional Divergence of Platelet Protein Kinase C (PKC) Isoforms in Thrombus Formation on Collagen
por: Gilio, Karen, et al.
Publicado: (2010)

The Application of Embelin for Cancer Prevention and Therapy †
por: Ko, Jeong-Hyeon, et al.
Publicado: (2018)

Amarogentin, a Secoiridoid Glycoside, Abrogates Platelet Activation through PLCγ2-PKC and MAPK Pathways
por: Yen, Ting-Lin, et al.
Publicado: (2014)

Thioredoxin Inhibitors Attenuate Platelet Function and Thrombus Formation
por: Metcalfe, Clive, et al.
Publicado: (2016)

Embelin as Lead Compound for New Neuroserpin Polymerization Inhibitors
por: Visentin, Cristina, et al.
Publicado: (2020)

Stress Degradation Studies on Embelin
por: Ferreira, Galvina, et al.
Publicado: (2013)

Platelet thrombus formation in eHUS is prevented by anti-MBL2
por: Kushak, R. I., et al.
Publicado: (2019)

Importance of Endogenous Fibrinolysis in Platelet Thrombus Formation
por: Gue, Ying X., et al.
Publicado: (2017)

Pentamethylquercetin (PMQ) reduces thrombus formation by inhibiting platelet function
por: Liang, Ming-Lu, et al.
Publicado: (2015)

Sanguinarine Attenuates Collagen-Induced Platelet Activation and Thrombus Formation
por: Shu, Dan, et al.
Publicado: (2021)

Humanin analogue, HNG, inhibits platelet activation and thrombus formation by stabilizing platelet microtubules
por: Ren, Lijie, et al.
Publicado: (2020)

Modulation of Platelet Activation and Thrombus Formation Using a Pan-PI3K Inhibitor S14161
por: Yi, Wenxiu, et al.
Publicado: (2014)

Quantification of Platelet Contractile Movements during Thrombus Formation
por: Tunströmer, Kjersti, et al.
Publicado: (2018)

An Antithrombotic Strategy by Targeting Phospholipase D in Human Platelets
por: Lu, Wan Jung, et al.
Publicado: (2018)

Methylglyoxal Induces Platelet Hyperaggregation and Reduces Thrombus Stability by Activating PKC and Inhibiting PI3K/Akt Pathway
por: Hadas, Karin, et al.
Publicado: (2013)

Honokiol as a specific collagen receptor glycoprotein VI antagonist on human platelets: Functional ex vivo and in vivo studies
por: Lee, Tzu-Yin, et al.
Publicado: (2017)

Differential Roles of the PKC Novel Isoforms, PKCδ and PKCε, in Mouse and Human Platelets
por: Pears, Catherine J., et al.
Publicado: (2008)

XIAP Antagonist Embelin Inhibited Proliferation of Cholangiocarcinoma Cells
por: Wehrkamp, Cody J., et al.
Publicado: (2014)

Embelin binds to human neuroserpin and impairs its polymerisation
por: Saga, Giorgia, et al.
Publicado: (2016)

Anti-plasmodial and Chloroquine Resistance Suppressive Effects of Embelin
por: Zaid, O.I., et al.
Publicado: (2017)

Pharmacological evaluation of embelin - chitosan nanoparticles as an antidiabetic agent
por: Maanvizhi, Saba, et al.
Publicado: (2022)

Synthesis of Quinoline and Dihydroquinoline Embelin Derivatives as Cardioprotective Agents
por: Martín-Acosta, Pedro, et al.
Publicado: (2023)

THE ELECTROPHORESIS OF THE BLOOD PLATELETS OF THE HORSE WITH REFERENCE TO THEIR ORIGIN AND TO THROMBUS FORMATION
por: Abramson, Harold A.
Publicado: (1928)

Chlorogenic Acid Inhibits Human Platelet Activation and Thrombus Formation
por: Fuentes, Eduardo, et al.
Publicado: (2014)

Regulation of platelet activation and thrombus formation by reactive oxygen species
por: Qiao, Jianlin, et al.
Publicado: (2017)

Functional Genomics for the Identification of Modulators of Platelet-Dependent Thrombus Formation
por: Vermeersch, Elien, et al.
Publicado: (2018)

Tumor-Educated Platelets Facilitate Thrombus Formation Through Migration
por: Liu, Zheming, et al.
Publicado: (2022)

Macrophage targeting contributes to the inhibitory effects of embelin on colitis-associated cancer
por: Wu, Ting, et al.
Publicado: (2016)

Xinmailong Modulates Platelet Function and Inhibits Thrombus Formation via the Platelet αIIbβ3-Mediated Signaling Pathway
por: Wang, Huawei, et al.
Publicado: (2019)

Pharmacokinetic and Bioavailability Studies of Embelin after Intravenous and Oral Administration to Rats
por: Li, Zhen, et al.
Publicado: (2019)

Platelet-derived porous nanomotor for thrombus therapy
por: Wan, Mimi, et al.
Publicado: (2020)

Embelin Restores Carbapenem Efficacy against NDM-1-Positive Pathogens
por: Ning, Nian-Zhi, et al.
Publicado: (2018)

Embelin Prevents Seizure and Associated Cognitive Impairments in a Pentylenetetrazole-Induced Kindling Zebrafish Model
por: Kundap, Uday Praful, et al.
Publicado: (2019)

Platycodin D inhibits platelet function and thrombus formation through inducing internalization of platelet glycoprotein receptors
por: Luo, Qi, et al.
Publicado: (2018)

Circadian nuclear receptor Rev-erbα is expressed by platelets and potentiates platelet activation and thrombus formation
por: Shi, Jianfeng, et al.
Publicado: (2022)

Design, synthesis and α-glucosidase inhibition study of novel embelin derivatives
por: Chen, Xiaole, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_beagv6b75fj4qb11rta6i7ebsb