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Serial, Visually-Evoked Potentials for the Assessment of Visual Function in Patients with Craniosynostosis

This study aimed to evaluate the effect of craniofacial surgical intervention on the visual pathway’s function by comparing pre- to post-operative patterned, visually-evoked potentials (pVEP). A retrospective review was conducted on craniosynostosis patients who had pre- and post-craniofacial surger...

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Autores principales: Haredy, Mostafa M., Liasis, Alki, Davis, Amani, Koesarie, Kathleen, Fu, Valeria, Losee, Joseph E., Goldstein, Jesse A., Nischal, Ken K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832611/
https://www.ncbi.nlm.nih.gov/pubmed/31569741
http://dx.doi.org/10.3390/jcm8101555
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author Haredy, Mostafa M.
Liasis, Alki
Davis, Amani
Koesarie, Kathleen
Fu, Valeria
Losee, Joseph E.
Goldstein, Jesse A.
Nischal, Ken K.
author_facet Haredy, Mostafa M.
Liasis, Alki
Davis, Amani
Koesarie, Kathleen
Fu, Valeria
Losee, Joseph E.
Goldstein, Jesse A.
Nischal, Ken K.
author_sort Haredy, Mostafa M.
collection PubMed
description This study aimed to evaluate the effect of craniofacial surgical intervention on the visual pathway’s function by comparing pre- to post-operative patterned, visually-evoked potentials (pVEP). A retrospective review was conducted on craniosynostosis patients who had pre- and post-craniofacial surgery pVEP testing. The pVEP measured grade in terms of amplitude latency and morphology of the waveforms. The pre- and post-operative results were compared. The study identified 63 patients (mean age at preoperative pVEP of 16.9 months). Preoperatively, 33 patients (52.4%) had abnormal pVEP. Nine patients had evidence of intracranial hypertension, and of those, eight (88.9%) had abnormal pVEP. Within 6 months postoperatively, 24 of 33 patients (72.7%) with abnormal preoperative pVEP developed normal postoperative pVEP, while all 30 patients with normal preoperative VEP maintained their normal results postoperatively. Significant improvements in pVEP latency in patients with broad or delayed latency waveforms was evident for subjects with preoperative grades 2–4 (grade 2, p = 0.015; grade 3, p = 0.029; grade 4; p = 0.007), while significant postoperative increase in amplitude was significant for patients with abnormally low amplitude grade 3 and 5 waveforms (grade 3, p = 0.011; grade 5, p = 0.029). Serial pVEP testing represents a useful tool for the early detection of visual pathway dysfunction and follow up visual pathway function in craniosynostosis. Surgical intervention for craniosynostosis can result in the reversal of preoperative pVEP abnormalities seen in these patients, resulting in the normalization of the pVEP waveform, amplitude and latency, depending on the preoperative pVEP abnormality.
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spelling pubmed-68326112019-11-25 Serial, Visually-Evoked Potentials for the Assessment of Visual Function in Patients with Craniosynostosis Haredy, Mostafa M. Liasis, Alki Davis, Amani Koesarie, Kathleen Fu, Valeria Losee, Joseph E. Goldstein, Jesse A. Nischal, Ken K. J Clin Med Article This study aimed to evaluate the effect of craniofacial surgical intervention on the visual pathway’s function by comparing pre- to post-operative patterned, visually-evoked potentials (pVEP). A retrospective review was conducted on craniosynostosis patients who had pre- and post-craniofacial surgery pVEP testing. The pVEP measured grade in terms of amplitude latency and morphology of the waveforms. The pre- and post-operative results were compared. The study identified 63 patients (mean age at preoperative pVEP of 16.9 months). Preoperatively, 33 patients (52.4%) had abnormal pVEP. Nine patients had evidence of intracranial hypertension, and of those, eight (88.9%) had abnormal pVEP. Within 6 months postoperatively, 24 of 33 patients (72.7%) with abnormal preoperative pVEP developed normal postoperative pVEP, while all 30 patients with normal preoperative VEP maintained their normal results postoperatively. Significant improvements in pVEP latency in patients with broad or delayed latency waveforms was evident for subjects with preoperative grades 2–4 (grade 2, p = 0.015; grade 3, p = 0.029; grade 4; p = 0.007), while significant postoperative increase in amplitude was significant for patients with abnormally low amplitude grade 3 and 5 waveforms (grade 3, p = 0.011; grade 5, p = 0.029). Serial pVEP testing represents a useful tool for the early detection of visual pathway dysfunction and follow up visual pathway function in craniosynostosis. Surgical intervention for craniosynostosis can result in the reversal of preoperative pVEP abnormalities seen in these patients, resulting in the normalization of the pVEP waveform, amplitude and latency, depending on the preoperative pVEP abnormality. MDPI 2019-09-27 /pmc/articles/PMC6832611/ /pubmed/31569741 http://dx.doi.org/10.3390/jcm8101555 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Haredy, Mostafa M.
Liasis, Alki
Davis, Amani
Koesarie, Kathleen
Fu, Valeria
Losee, Joseph E.
Goldstein, Jesse A.
Nischal, Ken K.
Serial, Visually-Evoked Potentials for the Assessment of Visual Function in Patients with Craniosynostosis
title Serial, Visually-Evoked Potentials for the Assessment of Visual Function in Patients with Craniosynostosis
title_full Serial, Visually-Evoked Potentials for the Assessment of Visual Function in Patients with Craniosynostosis
title_fullStr Serial, Visually-Evoked Potentials for the Assessment of Visual Function in Patients with Craniosynostosis
title_full_unstemmed Serial, Visually-Evoked Potentials for the Assessment of Visual Function in Patients with Craniosynostosis
title_short Serial, Visually-Evoked Potentials for the Assessment of Visual Function in Patients with Craniosynostosis
title_sort serial, visually-evoked potentials for the assessment of visual function in patients with craniosynostosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832611/
https://www.ncbi.nlm.nih.gov/pubmed/31569741
http://dx.doi.org/10.3390/jcm8101555
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