Insulin Hot-Spot Analogs Formed with N-Methylated Amino Acid Residues Inhibit Aggregation of Native Hormone

In this study, N-methylated analogs of hot-spots of insulin were designed and synthesized, in the expectation that they would inhibit the aggregation of both insulin hot-spots and the entire hormone. Synthesis of insulin “amyloidogenic” analogs containing N-methylated amino acid residues was perform...

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Detalles Bibliográficos
Autores principales: Swiontek, Monika, Wasko, Joanna, Fraczyk, Justyna, Galecki, Krystian, Kaminski, Zbigniew J., Kolesinska, Beata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832904/
https://www.ncbi.nlm.nih.gov/pubmed/31618999
http://dx.doi.org/10.3390/molecules24203706

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832904/
https://www.ncbi.nlm.nih.gov/pubmed/31618999
http://dx.doi.org/10.3390/molecules24203706

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