A Glimepiride-Metformin Multidrug Crystal: Synthesis, Crystal Structure Analysis, and Physicochemical Properties

A multidrug crystal based on drug combinations was synthesized by the solvent evaporation method. This multicomponent crystal consisted of antidiabetic drugs Glimepiride (Gli) and Metformin (Met), which was performed by single crystal X-ray structure analysis. The results showed an enhancement of th...

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Autores principales: Bian, Xufei, Jiang, Lan, Gan, Zongjie, Guan, Xiaoshu, Zhang, Li, Cai, Linhong, Hu, Xiangnan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832914/
https://www.ncbi.nlm.nih.gov/pubmed/31640214
http://dx.doi.org/10.3390/molecules24203786
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author Bian, Xufei
Jiang, Lan
Gan, Zongjie
Guan, Xiaoshu
Zhang, Li
Cai, Linhong
Hu, Xiangnan
author_facet Bian, Xufei
Jiang, Lan
Gan, Zongjie
Guan, Xiaoshu
Zhang, Li
Cai, Linhong
Hu, Xiangnan
author_sort Bian, Xufei
collection PubMed
description A multidrug crystal based on drug combinations was synthesized by the solvent evaporation method. This multicomponent crystal consisted of antidiabetic drugs Glimepiride (Gli) and Metformin (Met), which was performed by single crystal X-ray structure analysis. The results showed an enhancement of the pharmaceutical properties such as lower hygroscopicity and greater accelerated stability than the parent drug Met, and a higher solubility and dissolution rate than Gli.
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spelling pubmed-68329142019-11-25 A Glimepiride-Metformin Multidrug Crystal: Synthesis, Crystal Structure Analysis, and Physicochemical Properties Bian, Xufei Jiang, Lan Gan, Zongjie Guan, Xiaoshu Zhang, Li Cai, Linhong Hu, Xiangnan Molecules Article A multidrug crystal based on drug combinations was synthesized by the solvent evaporation method. This multicomponent crystal consisted of antidiabetic drugs Glimepiride (Gli) and Metformin (Met), which was performed by single crystal X-ray structure analysis. The results showed an enhancement of the pharmaceutical properties such as lower hygroscopicity and greater accelerated stability than the parent drug Met, and a higher solubility and dissolution rate than Gli. MDPI 2019-10-21 /pmc/articles/PMC6832914/ /pubmed/31640214 http://dx.doi.org/10.3390/molecules24203786 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bian, Xufei
Jiang, Lan
Gan, Zongjie
Guan, Xiaoshu
Zhang, Li
Cai, Linhong
Hu, Xiangnan
A Glimepiride-Metformin Multidrug Crystal: Synthesis, Crystal Structure Analysis, and Physicochemical Properties
title A Glimepiride-Metformin Multidrug Crystal: Synthesis, Crystal Structure Analysis, and Physicochemical Properties
title_full A Glimepiride-Metformin Multidrug Crystal: Synthesis, Crystal Structure Analysis, and Physicochemical Properties
title_fullStr A Glimepiride-Metformin Multidrug Crystal: Synthesis, Crystal Structure Analysis, and Physicochemical Properties
title_full_unstemmed A Glimepiride-Metformin Multidrug Crystal: Synthesis, Crystal Structure Analysis, and Physicochemical Properties
title_short A Glimepiride-Metformin Multidrug Crystal: Synthesis, Crystal Structure Analysis, and Physicochemical Properties
title_sort glimepiride-metformin multidrug crystal: synthesis, crystal structure analysis, and physicochemical properties
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832914/
https://www.ncbi.nlm.nih.gov/pubmed/31640214
http://dx.doi.org/10.3390/molecules24203786
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