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The White Blood Cell Count to Mean Platelet Volume Ratio for the Prediction of Chronic Limb-Threatening Ischemia in Lower Extremity Artery Disease

Background: The white blood cell count to mean platelet volume ratio (WMR) is increasingly gaining importance as a promising prognostic marker in atherosclerotic disease, but data on lower extremity artery disease (LEAD) are not yet available. The principle aim of this study was to assess the associ...

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Autores principales: Guetl, Katharina, Raggam, Reinhard Bernd, Muster, Viktoria, Gressenberger, Paul, Vujic, Jovan, Avian, Alexander, Hafner, Franz, Wehrschuetz, Martin, Brodmann, Marianne, Gary, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832925/
https://www.ncbi.nlm.nih.gov/pubmed/31581728
http://dx.doi.org/10.3390/jcm8101593
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author Guetl, Katharina
Raggam, Reinhard Bernd
Muster, Viktoria
Gressenberger, Paul
Vujic, Jovan
Avian, Alexander
Hafner, Franz
Wehrschuetz, Martin
Brodmann, Marianne
Gary, Thomas
author_facet Guetl, Katharina
Raggam, Reinhard Bernd
Muster, Viktoria
Gressenberger, Paul
Vujic, Jovan
Avian, Alexander
Hafner, Franz
Wehrschuetz, Martin
Brodmann, Marianne
Gary, Thomas
author_sort Guetl, Katharina
collection PubMed
description Background: The white blood cell count to mean platelet volume ratio (WMR) is increasingly gaining importance as a promising prognostic marker in atherosclerotic disease, but data on lower extremity artery disease (LEAD) are not yet available. The principle aim of this study was to assess the association of the WMR with the occurrence of CLTI (chronic limb-threatening ischemia) as the most advanced stage of disease. Methods: This study was performed as a retrospective analysis on 2121 patients with a diagnosis of LEAD. Patients were admitted to the hospital for the reason of LEAD and received conservative or endovascular treatment. Blood sampling, in order to obtain the required values for this analysis, was implemented at admission. Statistical analysis was conducted by univariate regression in a first step and, in case of significance, by multivariate regression additionally. Results: Multivariate regression revealed an increased WMR (p < 0.001, OR (95%CI) 2.258 (1.460–3.492)), but also advanced age (p < 0.001, OR (95%CI) 1.050 (1.040–1.061)), increased CRP (p < 0.001, OR (95%CI) 1.010 (1.007–1.014)), and diabetes (p < 0.001, OR (95%CI) 2.386 (1.933–2.946)) as independent predictors for CLTI. Conclusions: The WMR presents an easily obtainable and cost-effective parameter to identify LEAD patients at high risk for CLTI.
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spelling pubmed-68329252019-11-25 The White Blood Cell Count to Mean Platelet Volume Ratio for the Prediction of Chronic Limb-Threatening Ischemia in Lower Extremity Artery Disease Guetl, Katharina Raggam, Reinhard Bernd Muster, Viktoria Gressenberger, Paul Vujic, Jovan Avian, Alexander Hafner, Franz Wehrschuetz, Martin Brodmann, Marianne Gary, Thomas J Clin Med Article Background: The white blood cell count to mean platelet volume ratio (WMR) is increasingly gaining importance as a promising prognostic marker in atherosclerotic disease, but data on lower extremity artery disease (LEAD) are not yet available. The principle aim of this study was to assess the association of the WMR with the occurrence of CLTI (chronic limb-threatening ischemia) as the most advanced stage of disease. Methods: This study was performed as a retrospective analysis on 2121 patients with a diagnosis of LEAD. Patients were admitted to the hospital for the reason of LEAD and received conservative or endovascular treatment. Blood sampling, in order to obtain the required values for this analysis, was implemented at admission. Statistical analysis was conducted by univariate regression in a first step and, in case of significance, by multivariate regression additionally. Results: Multivariate regression revealed an increased WMR (p < 0.001, OR (95%CI) 2.258 (1.460–3.492)), but also advanced age (p < 0.001, OR (95%CI) 1.050 (1.040–1.061)), increased CRP (p < 0.001, OR (95%CI) 1.010 (1.007–1.014)), and diabetes (p < 0.001, OR (95%CI) 2.386 (1.933–2.946)) as independent predictors for CLTI. Conclusions: The WMR presents an easily obtainable and cost-effective parameter to identify LEAD patients at high risk for CLTI. MDPI 2019-10-02 /pmc/articles/PMC6832925/ /pubmed/31581728 http://dx.doi.org/10.3390/jcm8101593 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Guetl, Katharina
Raggam, Reinhard Bernd
Muster, Viktoria
Gressenberger, Paul
Vujic, Jovan
Avian, Alexander
Hafner, Franz
Wehrschuetz, Martin
Brodmann, Marianne
Gary, Thomas
The White Blood Cell Count to Mean Platelet Volume Ratio for the Prediction of Chronic Limb-Threatening Ischemia in Lower Extremity Artery Disease
title The White Blood Cell Count to Mean Platelet Volume Ratio for the Prediction of Chronic Limb-Threatening Ischemia in Lower Extremity Artery Disease
title_full The White Blood Cell Count to Mean Platelet Volume Ratio for the Prediction of Chronic Limb-Threatening Ischemia in Lower Extremity Artery Disease
title_fullStr The White Blood Cell Count to Mean Platelet Volume Ratio for the Prediction of Chronic Limb-Threatening Ischemia in Lower Extremity Artery Disease
title_full_unstemmed The White Blood Cell Count to Mean Platelet Volume Ratio for the Prediction of Chronic Limb-Threatening Ischemia in Lower Extremity Artery Disease
title_short The White Blood Cell Count to Mean Platelet Volume Ratio for the Prediction of Chronic Limb-Threatening Ischemia in Lower Extremity Artery Disease
title_sort white blood cell count to mean platelet volume ratio for the prediction of chronic limb-threatening ischemia in lower extremity artery disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832925/
https://www.ncbi.nlm.nih.gov/pubmed/31581728
http://dx.doi.org/10.3390/jcm8101593
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