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Osteoporosis from an Endocrine Perspective: The Role of Hormonal Changes in the Elderly

Introduction: Osteoporosis is increasingly prevalent in the elderly, with fractures mostly occurring in women and men who are older than 55 and 65 years of age, respectively. The aim of this review was to examine the evidence regarding the influence of hormones on bone metabolism, followed by clinic...

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Autores principales: Cannarella, Rossella, Barbagallo, Federica, Condorelli, Rosita A., Aversa, Antonio, La Vignera, Sandro, Calogero, Aldo E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832998/
https://www.ncbi.nlm.nih.gov/pubmed/31581477
http://dx.doi.org/10.3390/jcm8101564
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author Cannarella, Rossella
Barbagallo, Federica
Condorelli, Rosita A.
Aversa, Antonio
La Vignera, Sandro
Calogero, Aldo E.
author_facet Cannarella, Rossella
Barbagallo, Federica
Condorelli, Rosita A.
Aversa, Antonio
La Vignera, Sandro
Calogero, Aldo E.
author_sort Cannarella, Rossella
collection PubMed
description Introduction: Osteoporosis is increasingly prevalent in the elderly, with fractures mostly occurring in women and men who are older than 55 and 65 years of age, respectively. The aim of this review was to examine the evidence regarding the influence of hormones on bone metabolism, followed by clinical data of hormonal changes in the elderly, in the attempt to provide possible poorly explored diagnostic and therapeutic candidate targets for the management of primary osteoporosis in the aging population. Material and methods: An extensive Medline search using PubMed, Embase, and Cochrane Library was performed. Results: While the rise in Thyroid-stimulating hormone (TSH) levels has a protective role on bone mass, the decline of estrogen, testosterone, Insulin-like growth factor 1 (IGF1), and vitamin D and the rise of cortisol, parathyroid hormone, and follicle-stimulating hormone (FSH) favor bone loss in the elderly. Particularly, the AA rs6166 FSH receptor (FSHR) genotype, encoding for a more sensitive FSHR than that encoded by the GG one, is associated with low total body mass density (BMD), independently of circulating estrogen. A polyclonal antibody with a FSHR-binding sequence against the β-subunit of murine FSH seems to be effective in ameliorating bone loss in ovariectomized mice. Conclusions: A complete hormonal assessment should be completed for both women and men during bone loss evaluation. Novel possible diagnostic and therapeutic tools might be developed for the management of male and female osteoporosis.
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spelling pubmed-68329982019-11-25 Osteoporosis from an Endocrine Perspective: The Role of Hormonal Changes in the Elderly Cannarella, Rossella Barbagallo, Federica Condorelli, Rosita A. Aversa, Antonio La Vignera, Sandro Calogero, Aldo E. J Clin Med Review Introduction: Osteoporosis is increasingly prevalent in the elderly, with fractures mostly occurring in women and men who are older than 55 and 65 years of age, respectively. The aim of this review was to examine the evidence regarding the influence of hormones on bone metabolism, followed by clinical data of hormonal changes in the elderly, in the attempt to provide possible poorly explored diagnostic and therapeutic candidate targets for the management of primary osteoporosis in the aging population. Material and methods: An extensive Medline search using PubMed, Embase, and Cochrane Library was performed. Results: While the rise in Thyroid-stimulating hormone (TSH) levels has a protective role on bone mass, the decline of estrogen, testosterone, Insulin-like growth factor 1 (IGF1), and vitamin D and the rise of cortisol, parathyroid hormone, and follicle-stimulating hormone (FSH) favor bone loss in the elderly. Particularly, the AA rs6166 FSH receptor (FSHR) genotype, encoding for a more sensitive FSHR than that encoded by the GG one, is associated with low total body mass density (BMD), independently of circulating estrogen. A polyclonal antibody with a FSHR-binding sequence against the β-subunit of murine FSH seems to be effective in ameliorating bone loss in ovariectomized mice. Conclusions: A complete hormonal assessment should be completed for both women and men during bone loss evaluation. Novel possible diagnostic and therapeutic tools might be developed for the management of male and female osteoporosis. MDPI 2019-10-01 /pmc/articles/PMC6832998/ /pubmed/31581477 http://dx.doi.org/10.3390/jcm8101564 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cannarella, Rossella
Barbagallo, Federica
Condorelli, Rosita A.
Aversa, Antonio
La Vignera, Sandro
Calogero, Aldo E.
Osteoporosis from an Endocrine Perspective: The Role of Hormonal Changes in the Elderly
title Osteoporosis from an Endocrine Perspective: The Role of Hormonal Changes in the Elderly
title_full Osteoporosis from an Endocrine Perspective: The Role of Hormonal Changes in the Elderly
title_fullStr Osteoporosis from an Endocrine Perspective: The Role of Hormonal Changes in the Elderly
title_full_unstemmed Osteoporosis from an Endocrine Perspective: The Role of Hormonal Changes in the Elderly
title_short Osteoporosis from an Endocrine Perspective: The Role of Hormonal Changes in the Elderly
title_sort osteoporosis from an endocrine perspective: the role of hormonal changes in the elderly
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832998/
https://www.ncbi.nlm.nih.gov/pubmed/31581477
http://dx.doi.org/10.3390/jcm8101564
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