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Association of Serum PCSK9 Levels with Antibiotic Resistance and Severity of Disease in Patients with Bacterial Infections Admitted to Intensive Care Units

Background: The results of several studies have suggested that infections and sepsis, either bacterial or viral, might be associated with elevated plasma proprotein convertase subtilisin/kexin type 9 (PCSK9) levels. Since there are no data on PCSK9 levels and antibiotic resistance or the severity of...

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Autores principales: Jamialahmadi, Tannaz, Panahi, Yunes, Safarpour, Mohamamd Amin, Ganjali, Shiva, Chahabi, Mahdi, Reiner, Zeljko, Solgi, Saeed, Vahedian-azimi, Amir, Kianpour, Parisa, Banach, Maciej, Sahebkar, Amirhossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833014/
https://www.ncbi.nlm.nih.gov/pubmed/31635200
http://dx.doi.org/10.3390/jcm8101742
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author Jamialahmadi, Tannaz
Panahi, Yunes
Safarpour, Mohamamd Amin
Ganjali, Shiva
Chahabi, Mahdi
Reiner, Zeljko
Solgi, Saeed
Vahedian-azimi, Amir
Kianpour, Parisa
Banach, Maciej
Sahebkar, Amirhossein
author_facet Jamialahmadi, Tannaz
Panahi, Yunes
Safarpour, Mohamamd Amin
Ganjali, Shiva
Chahabi, Mahdi
Reiner, Zeljko
Solgi, Saeed
Vahedian-azimi, Amir
Kianpour, Parisa
Banach, Maciej
Sahebkar, Amirhossein
author_sort Jamialahmadi, Tannaz
collection PubMed
description Background: The results of several studies have suggested that infections and sepsis, either bacterial or viral, might be associated with elevated plasma proprotein convertase subtilisin/kexin type 9 (PCSK9) levels. Since there are no data on PCSK9 levels and antibiotic resistance or the severity of disease in patients with bacterial infections in intensive care units, the aim of this study was to investigate whether any such associations exist. Methods: 100 patients (46 males, mean age 67.12 ± 1.34 years) with bacterial infections who were staying in an intensive care unit (ICU) longer than 48 h but less than 7 days and who were not receiving corticosteroids were analyzed. Their serum levels of albumin, C-reactive protein, glucose, lactate, blood urea nitrogen, prothrombin (international normalized ratio), total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, PCSK9, and procalcitonin were measured. The severity of the patients’ condition was assessed by using the Glasgow Coma Scale (GCS), the Sequential Organ Failure Assessment (SOFA), and the Acute Physiology and Chronic Health Evaluation II (APACHE II) scales. Results: Using a hierarchical regression modeling approach, no significant association was found between PCSK9 levels and either the severity of disease (APACHE II, SOFA, and GCS) indices or resistance to antibiotics. Conclusion: The results suggest that there is no association between PCSK9 levels and resistance to antibiotics or the condition of patients hospitalized in intensive care units.
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spelling pubmed-68330142019-11-25 Association of Serum PCSK9 Levels with Antibiotic Resistance and Severity of Disease in Patients with Bacterial Infections Admitted to Intensive Care Units Jamialahmadi, Tannaz Panahi, Yunes Safarpour, Mohamamd Amin Ganjali, Shiva Chahabi, Mahdi Reiner, Zeljko Solgi, Saeed Vahedian-azimi, Amir Kianpour, Parisa Banach, Maciej Sahebkar, Amirhossein J Clin Med Article Background: The results of several studies have suggested that infections and sepsis, either bacterial or viral, might be associated with elevated plasma proprotein convertase subtilisin/kexin type 9 (PCSK9) levels. Since there are no data on PCSK9 levels and antibiotic resistance or the severity of disease in patients with bacterial infections in intensive care units, the aim of this study was to investigate whether any such associations exist. Methods: 100 patients (46 males, mean age 67.12 ± 1.34 years) with bacterial infections who were staying in an intensive care unit (ICU) longer than 48 h but less than 7 days and who were not receiving corticosteroids were analyzed. Their serum levels of albumin, C-reactive protein, glucose, lactate, blood urea nitrogen, prothrombin (international normalized ratio), total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, PCSK9, and procalcitonin were measured. The severity of the patients’ condition was assessed by using the Glasgow Coma Scale (GCS), the Sequential Organ Failure Assessment (SOFA), and the Acute Physiology and Chronic Health Evaluation II (APACHE II) scales. Results: Using a hierarchical regression modeling approach, no significant association was found between PCSK9 levels and either the severity of disease (APACHE II, SOFA, and GCS) indices or resistance to antibiotics. Conclusion: The results suggest that there is no association between PCSK9 levels and resistance to antibiotics or the condition of patients hospitalized in intensive care units. MDPI 2019-10-20 /pmc/articles/PMC6833014/ /pubmed/31635200 http://dx.doi.org/10.3390/jcm8101742 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jamialahmadi, Tannaz
Panahi, Yunes
Safarpour, Mohamamd Amin
Ganjali, Shiva
Chahabi, Mahdi
Reiner, Zeljko
Solgi, Saeed
Vahedian-azimi, Amir
Kianpour, Parisa
Banach, Maciej
Sahebkar, Amirhossein
Association of Serum PCSK9 Levels with Antibiotic Resistance and Severity of Disease in Patients with Bacterial Infections Admitted to Intensive Care Units
title Association of Serum PCSK9 Levels with Antibiotic Resistance and Severity of Disease in Patients with Bacterial Infections Admitted to Intensive Care Units
title_full Association of Serum PCSK9 Levels with Antibiotic Resistance and Severity of Disease in Patients with Bacterial Infections Admitted to Intensive Care Units
title_fullStr Association of Serum PCSK9 Levels with Antibiotic Resistance and Severity of Disease in Patients with Bacterial Infections Admitted to Intensive Care Units
title_full_unstemmed Association of Serum PCSK9 Levels with Antibiotic Resistance and Severity of Disease in Patients with Bacterial Infections Admitted to Intensive Care Units
title_short Association of Serum PCSK9 Levels with Antibiotic Resistance and Severity of Disease in Patients with Bacterial Infections Admitted to Intensive Care Units
title_sort association of serum pcsk9 levels with antibiotic resistance and severity of disease in patients with bacterial infections admitted to intensive care units
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833014/
https://www.ncbi.nlm.nih.gov/pubmed/31635200
http://dx.doi.org/10.3390/jcm8101742
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