Cargando…
Follow-Up Recommendations after Curative Resection of Well-Differentiated Neuroendocrine Tumours: Review of Current Evidence and Clinical Practice
The incidence of neuroendocrine neoplasms (NENs) is increasing, especially for patients with early stages and grade 1 tumours. Current evidence also shows increased prevalence, probably reflecting earlier stage diagnosis and improvement of treatment options. Definition of adequate postsurgical follo...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833016/ https://www.ncbi.nlm.nih.gov/pubmed/31590343 http://dx.doi.org/10.3390/jcm8101630 |
_version_ | 1783466279760297984 |
---|---|
author | Lamarca, Angela Clouston, Hamish Barriuso, Jorge McNamara, Mairéad G Frizziero, Melissa Mansoor, Was Hubner, Richard A Manoharan, Prakash O’Dwyer, Sarah Valle, Juan W |
author_facet | Lamarca, Angela Clouston, Hamish Barriuso, Jorge McNamara, Mairéad G Frizziero, Melissa Mansoor, Was Hubner, Richard A Manoharan, Prakash O’Dwyer, Sarah Valle, Juan W |
author_sort | Lamarca, Angela |
collection | PubMed |
description | The incidence of neuroendocrine neoplasms (NENs) is increasing, especially for patients with early stages and grade 1 tumours. Current evidence also shows increased prevalence, probably reflecting earlier stage diagnosis and improvement of treatment options. Definition of adequate postsurgical follow-up for NENs is a current challenge. There are limited guidelines, and heterogeneity in adherence to those available is notable. Unfortunately, the population of patients at greatest risk of recurrence has not been defined clearly. Some studies support that for patients with pancreatic neuroendocrine tumours (PanNETs), factors such as primary tumour (T), stage, grade (Ki-67), tumour size, and lymph node metastases (N) are of relevance. For bronchial neuroendocrine tumours (LungNETs) and small intestinal neuroendocrine tumours (siNETs), similar factors have been identified. This review summarises the evidence supporting the rationale behind follow-up after curative resection in well-differentiated PanNETs, siNETs, and LungNETS. Published evidence informing relapse rate, disease-free survival, and relapse patterns are discussed, together with an overview of current guidelines informing postsurgical investigations and duration of follow-up. |
format | Online Article Text |
id | pubmed-6833016 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-68330162019-11-25 Follow-Up Recommendations after Curative Resection of Well-Differentiated Neuroendocrine Tumours: Review of Current Evidence and Clinical Practice Lamarca, Angela Clouston, Hamish Barriuso, Jorge McNamara, Mairéad G Frizziero, Melissa Mansoor, Was Hubner, Richard A Manoharan, Prakash O’Dwyer, Sarah Valle, Juan W J Clin Med Review The incidence of neuroendocrine neoplasms (NENs) is increasing, especially for patients with early stages and grade 1 tumours. Current evidence also shows increased prevalence, probably reflecting earlier stage diagnosis and improvement of treatment options. Definition of adequate postsurgical follow-up for NENs is a current challenge. There are limited guidelines, and heterogeneity in adherence to those available is notable. Unfortunately, the population of patients at greatest risk of recurrence has not been defined clearly. Some studies support that for patients with pancreatic neuroendocrine tumours (PanNETs), factors such as primary tumour (T), stage, grade (Ki-67), tumour size, and lymph node metastases (N) are of relevance. For bronchial neuroendocrine tumours (LungNETs) and small intestinal neuroendocrine tumours (siNETs), similar factors have been identified. This review summarises the evidence supporting the rationale behind follow-up after curative resection in well-differentiated PanNETs, siNETs, and LungNETS. Published evidence informing relapse rate, disease-free survival, and relapse patterns are discussed, together with an overview of current guidelines informing postsurgical investigations and duration of follow-up. MDPI 2019-10-05 /pmc/articles/PMC6833016/ /pubmed/31590343 http://dx.doi.org/10.3390/jcm8101630 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lamarca, Angela Clouston, Hamish Barriuso, Jorge McNamara, Mairéad G Frizziero, Melissa Mansoor, Was Hubner, Richard A Manoharan, Prakash O’Dwyer, Sarah Valle, Juan W Follow-Up Recommendations after Curative Resection of Well-Differentiated Neuroendocrine Tumours: Review of Current Evidence and Clinical Practice |
title | Follow-Up Recommendations after Curative Resection of Well-Differentiated Neuroendocrine Tumours: Review of Current Evidence and Clinical Practice |
title_full | Follow-Up Recommendations after Curative Resection of Well-Differentiated Neuroendocrine Tumours: Review of Current Evidence and Clinical Practice |
title_fullStr | Follow-Up Recommendations after Curative Resection of Well-Differentiated Neuroendocrine Tumours: Review of Current Evidence and Clinical Practice |
title_full_unstemmed | Follow-Up Recommendations after Curative Resection of Well-Differentiated Neuroendocrine Tumours: Review of Current Evidence and Clinical Practice |
title_short | Follow-Up Recommendations after Curative Resection of Well-Differentiated Neuroendocrine Tumours: Review of Current Evidence and Clinical Practice |
title_sort | follow-up recommendations after curative resection of well-differentiated neuroendocrine tumours: review of current evidence and clinical practice |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833016/ https://www.ncbi.nlm.nih.gov/pubmed/31590343 http://dx.doi.org/10.3390/jcm8101630 |
work_keys_str_mv | AT lamarcaangela followuprecommendationsaftercurativeresectionofwelldifferentiatedneuroendocrinetumoursreviewofcurrentevidenceandclinicalpractice AT cloustonhamish followuprecommendationsaftercurativeresectionofwelldifferentiatedneuroendocrinetumoursreviewofcurrentevidenceandclinicalpractice AT barriusojorge followuprecommendationsaftercurativeresectionofwelldifferentiatedneuroendocrinetumoursreviewofcurrentevidenceandclinicalpractice AT mcnamaramaireadg followuprecommendationsaftercurativeresectionofwelldifferentiatedneuroendocrinetumoursreviewofcurrentevidenceandclinicalpractice AT frizzieromelissa followuprecommendationsaftercurativeresectionofwelldifferentiatedneuroendocrinetumoursreviewofcurrentevidenceandclinicalpractice AT mansoorwas followuprecommendationsaftercurativeresectionofwelldifferentiatedneuroendocrinetumoursreviewofcurrentevidenceandclinicalpractice AT hubnerricharda followuprecommendationsaftercurativeresectionofwelldifferentiatedneuroendocrinetumoursreviewofcurrentevidenceandclinicalpractice AT manoharanprakash followuprecommendationsaftercurativeresectionofwelldifferentiatedneuroendocrinetumoursreviewofcurrentevidenceandclinicalpractice AT odwyersarah followuprecommendationsaftercurativeresectionofwelldifferentiatedneuroendocrinetumoursreviewofcurrentevidenceandclinicalpractice AT vallejuanw followuprecommendationsaftercurativeresectionofwelldifferentiatedneuroendocrinetumoursreviewofcurrentevidenceandclinicalpractice |