Two Novel Polysaccharides in Psoralea corylifolia L and anti-A549 Lung Cancer Cells Activity In Vitro

Two novel water soluble heteroglycan (PCp-I and PCp-II) with anti-A549 lung cancer cells activity were isolated from Psoralea corylifolia L. Their average molecular weights were 2.721 × 10(4) and 2.850 × 10(4). PCp-I and PCp-II had the same monosaccharide composition, but their molar ratios were dif...

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Autores principales: Yin, Zhenhua, Zhang, Wei, Zhang, Juanjuan, Liu, Huili, Guo, Qingfeng, Chen, Lin, Wang, Jinmei, Kang, Wenyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833038/
https://www.ncbi.nlm.nih.gov/pubmed/31623207
http://dx.doi.org/10.3390/molecules24203733
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author Yin, Zhenhua
Zhang, Wei
Zhang, Juanjuan
Liu, Huili
Guo, Qingfeng
Chen, Lin
Wang, Jinmei
Kang, Wenyi
author_facet Yin, Zhenhua
Zhang, Wei
Zhang, Juanjuan
Liu, Huili
Guo, Qingfeng
Chen, Lin
Wang, Jinmei
Kang, Wenyi
author_sort Yin, Zhenhua
collection PubMed
description Two novel water soluble heteroglycan (PCp-I and PCp-II) with anti-A549 lung cancer cells activity were isolated from Psoralea corylifolia L. Their average molecular weights were 2.721 × 10(4) and 2.850 × 10(4). PCp-I and PCp-II had the same monosaccharide composition, but their molar ratios were different. Based on methylation and NMR spectroscopy, the part structure of PCp-I was identified. The results of scanning electron microscope (SEM) showed that PCp-I had an irregular porous structure and PCp-II was flaky and irregularly curved. The results of thermogravimetry-differential scanning calorimetry (TG-DSC) showed that PCp-I and PCp-II had good thermal stability. Furthermore, PCp-I and PCp-II exhibited significant anti-A549 lung cancer cells activity (IC(50) = 64.84 and 126.30 μM) in vitro.
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spelling pubmed-68330382019-11-25 Two Novel Polysaccharides in Psoralea corylifolia L and anti-A549 Lung Cancer Cells Activity In Vitro Yin, Zhenhua Zhang, Wei Zhang, Juanjuan Liu, Huili Guo, Qingfeng Chen, Lin Wang, Jinmei Kang, Wenyi Molecules Article Two novel water soluble heteroglycan (PCp-I and PCp-II) with anti-A549 lung cancer cells activity were isolated from Psoralea corylifolia L. Their average molecular weights were 2.721 × 10(4) and 2.850 × 10(4). PCp-I and PCp-II had the same monosaccharide composition, but their molar ratios were different. Based on methylation and NMR spectroscopy, the part structure of PCp-I was identified. The results of scanning electron microscope (SEM) showed that PCp-I had an irregular porous structure and PCp-II was flaky and irregularly curved. The results of thermogravimetry-differential scanning calorimetry (TG-DSC) showed that PCp-I and PCp-II had good thermal stability. Furthermore, PCp-I and PCp-II exhibited significant anti-A549 lung cancer cells activity (IC(50) = 64.84 and 126.30 μM) in vitro. MDPI 2019-10-16 /pmc/articles/PMC6833038/ /pubmed/31623207 http://dx.doi.org/10.3390/molecules24203733 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yin, Zhenhua
Zhang, Wei
Zhang, Juanjuan
Liu, Huili
Guo, Qingfeng
Chen, Lin
Wang, Jinmei
Kang, Wenyi
Two Novel Polysaccharides in Psoralea corylifolia L and anti-A549 Lung Cancer Cells Activity In Vitro
title Two Novel Polysaccharides in Psoralea corylifolia L and anti-A549 Lung Cancer Cells Activity In Vitro
title_full Two Novel Polysaccharides in Psoralea corylifolia L and anti-A549 Lung Cancer Cells Activity In Vitro
title_fullStr Two Novel Polysaccharides in Psoralea corylifolia L and anti-A549 Lung Cancer Cells Activity In Vitro
title_full_unstemmed Two Novel Polysaccharides in Psoralea corylifolia L and anti-A549 Lung Cancer Cells Activity In Vitro
title_short Two Novel Polysaccharides in Psoralea corylifolia L and anti-A549 Lung Cancer Cells Activity In Vitro
title_sort two novel polysaccharides in psoralea corylifolia l and anti-a549 lung cancer cells activity in vitro
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833038/
https://www.ncbi.nlm.nih.gov/pubmed/31623207
http://dx.doi.org/10.3390/molecules24203733
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