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Chronic Stress, Inflammation, and Colon Cancer: A CRH System-Driven Molecular Crosstalk

Chronic stress is thought to be involved in the occurrence and progression of multiple diseases, via mechanisms that still remain largely unknown. Interestingly, key regulators of the stress response, such as members of the corticotropin-releasing-hormone (CRH) family of neuropeptides and receptors,...

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Autores principales: Baritaki, Stavroula, de Bree, Eelco, Chatzaki, Ekaterini, Pothoulakis, Charalabos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833069/
https://www.ncbi.nlm.nih.gov/pubmed/31614860
http://dx.doi.org/10.3390/jcm8101669
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author Baritaki, Stavroula
de Bree, Eelco
Chatzaki, Ekaterini
Pothoulakis, Charalabos
author_facet Baritaki, Stavroula
de Bree, Eelco
Chatzaki, Ekaterini
Pothoulakis, Charalabos
author_sort Baritaki, Stavroula
collection PubMed
description Chronic stress is thought to be involved in the occurrence and progression of multiple diseases, via mechanisms that still remain largely unknown. Interestingly, key regulators of the stress response, such as members of the corticotropin-releasing-hormone (CRH) family of neuropeptides and receptors, are now known to be implicated in the regulation of chronic inflammation, one of the predisposing factors for oncogenesis and disease progression. However, an interrelationship between stress, inflammation, and malignancy, at least at the molecular level, still remains unclear. Here, we attempt to summarize the current knowledge that supports the inseparable link between chronic stress, inflammation, and colorectal cancer (CRC), by modulation of a cascade of molecular signaling pathways, which are under the regulation of CRH-family members expressed in the brain and periphery. The understanding of the molecular basis of the link among these processes may provide a step forward towards personalized medicine in terms of CRC diagnosis, prognosis and therapeutic targeting.
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spelling pubmed-68330692019-11-25 Chronic Stress, Inflammation, and Colon Cancer: A CRH System-Driven Molecular Crosstalk Baritaki, Stavroula de Bree, Eelco Chatzaki, Ekaterini Pothoulakis, Charalabos J Clin Med Review Chronic stress is thought to be involved in the occurrence and progression of multiple diseases, via mechanisms that still remain largely unknown. Interestingly, key regulators of the stress response, such as members of the corticotropin-releasing-hormone (CRH) family of neuropeptides and receptors, are now known to be implicated in the regulation of chronic inflammation, one of the predisposing factors for oncogenesis and disease progression. However, an interrelationship between stress, inflammation, and malignancy, at least at the molecular level, still remains unclear. Here, we attempt to summarize the current knowledge that supports the inseparable link between chronic stress, inflammation, and colorectal cancer (CRC), by modulation of a cascade of molecular signaling pathways, which are under the regulation of CRH-family members expressed in the brain and periphery. The understanding of the molecular basis of the link among these processes may provide a step forward towards personalized medicine in terms of CRC diagnosis, prognosis and therapeutic targeting. MDPI 2019-10-12 /pmc/articles/PMC6833069/ /pubmed/31614860 http://dx.doi.org/10.3390/jcm8101669 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Baritaki, Stavroula
de Bree, Eelco
Chatzaki, Ekaterini
Pothoulakis, Charalabos
Chronic Stress, Inflammation, and Colon Cancer: A CRH System-Driven Molecular Crosstalk
title Chronic Stress, Inflammation, and Colon Cancer: A CRH System-Driven Molecular Crosstalk
title_full Chronic Stress, Inflammation, and Colon Cancer: A CRH System-Driven Molecular Crosstalk
title_fullStr Chronic Stress, Inflammation, and Colon Cancer: A CRH System-Driven Molecular Crosstalk
title_full_unstemmed Chronic Stress, Inflammation, and Colon Cancer: A CRH System-Driven Molecular Crosstalk
title_short Chronic Stress, Inflammation, and Colon Cancer: A CRH System-Driven Molecular Crosstalk
title_sort chronic stress, inflammation, and colon cancer: a crh system-driven molecular crosstalk
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833069/
https://www.ncbi.nlm.nih.gov/pubmed/31614860
http://dx.doi.org/10.3390/jcm8101669
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