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Chronic Stress, Inflammation, and Colon Cancer: A CRH System-Driven Molecular Crosstalk
Chronic stress is thought to be involved in the occurrence and progression of multiple diseases, via mechanisms that still remain largely unknown. Interestingly, key regulators of the stress response, such as members of the corticotropin-releasing-hormone (CRH) family of neuropeptides and receptors,...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833069/ https://www.ncbi.nlm.nih.gov/pubmed/31614860 http://dx.doi.org/10.3390/jcm8101669 |
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author | Baritaki, Stavroula de Bree, Eelco Chatzaki, Ekaterini Pothoulakis, Charalabos |
author_facet | Baritaki, Stavroula de Bree, Eelco Chatzaki, Ekaterini Pothoulakis, Charalabos |
author_sort | Baritaki, Stavroula |
collection | PubMed |
description | Chronic stress is thought to be involved in the occurrence and progression of multiple diseases, via mechanisms that still remain largely unknown. Interestingly, key regulators of the stress response, such as members of the corticotropin-releasing-hormone (CRH) family of neuropeptides and receptors, are now known to be implicated in the regulation of chronic inflammation, one of the predisposing factors for oncogenesis and disease progression. However, an interrelationship between stress, inflammation, and malignancy, at least at the molecular level, still remains unclear. Here, we attempt to summarize the current knowledge that supports the inseparable link between chronic stress, inflammation, and colorectal cancer (CRC), by modulation of a cascade of molecular signaling pathways, which are under the regulation of CRH-family members expressed in the brain and periphery. The understanding of the molecular basis of the link among these processes may provide a step forward towards personalized medicine in terms of CRC diagnosis, prognosis and therapeutic targeting. |
format | Online Article Text |
id | pubmed-6833069 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-68330692019-11-25 Chronic Stress, Inflammation, and Colon Cancer: A CRH System-Driven Molecular Crosstalk Baritaki, Stavroula de Bree, Eelco Chatzaki, Ekaterini Pothoulakis, Charalabos J Clin Med Review Chronic stress is thought to be involved in the occurrence and progression of multiple diseases, via mechanisms that still remain largely unknown. Interestingly, key regulators of the stress response, such as members of the corticotropin-releasing-hormone (CRH) family of neuropeptides and receptors, are now known to be implicated in the regulation of chronic inflammation, one of the predisposing factors for oncogenesis and disease progression. However, an interrelationship between stress, inflammation, and malignancy, at least at the molecular level, still remains unclear. Here, we attempt to summarize the current knowledge that supports the inseparable link between chronic stress, inflammation, and colorectal cancer (CRC), by modulation of a cascade of molecular signaling pathways, which are under the regulation of CRH-family members expressed in the brain and periphery. The understanding of the molecular basis of the link among these processes may provide a step forward towards personalized medicine in terms of CRC diagnosis, prognosis and therapeutic targeting. MDPI 2019-10-12 /pmc/articles/PMC6833069/ /pubmed/31614860 http://dx.doi.org/10.3390/jcm8101669 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Baritaki, Stavroula de Bree, Eelco Chatzaki, Ekaterini Pothoulakis, Charalabos Chronic Stress, Inflammation, and Colon Cancer: A CRH System-Driven Molecular Crosstalk |
title | Chronic Stress, Inflammation, and Colon Cancer: A CRH System-Driven Molecular Crosstalk |
title_full | Chronic Stress, Inflammation, and Colon Cancer: A CRH System-Driven Molecular Crosstalk |
title_fullStr | Chronic Stress, Inflammation, and Colon Cancer: A CRH System-Driven Molecular Crosstalk |
title_full_unstemmed | Chronic Stress, Inflammation, and Colon Cancer: A CRH System-Driven Molecular Crosstalk |
title_short | Chronic Stress, Inflammation, and Colon Cancer: A CRH System-Driven Molecular Crosstalk |
title_sort | chronic stress, inflammation, and colon cancer: a crh system-driven molecular crosstalk |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833069/ https://www.ncbi.nlm.nih.gov/pubmed/31614860 http://dx.doi.org/10.3390/jcm8101669 |
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