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CRL4 ubiquitin ligase stimulates Fanconi anemia pathway-induced single-stranded DNA-RPA signaling

BACKGROUND: DNA-crosslinking agents like cisplatin and mitomycin C (MMC) are indispensible for the treatment of many solid malignancies. These anticancer drugs generate DNA interstrand crosslinks (ICLs) that cause cell death by blocking replication forks. Many factors counteracting ICL-induced DNA r...

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Detalles Bibliográficos
Autores principales:	Codilupi, Tamara, Taube, Doreen, Naegeli, Hanspeter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833152/ https://www.ncbi.nlm.nih.gov/pubmed/31690264 http://dx.doi.org/10.1186/s12885-019-6305-x

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