Chronic TCR-MHC (self)-interactions limit the functional potential of TCR affinity-increased CD8 T lymphocytes

BACKGROUND: Affinity-optimized T cell receptor (TCR)-engineered lymphocytes targeting tumor antigens can mediate potent antitumor responses in cancer patients, but also bear substantial risks for off-target toxicities. Most preclinical studies have focused on T cell responses to antigen-specific sti...

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Detalles Bibliográficos
Autores principales: Duong, Minh Ngoc, Erdes, Efe, Hebeisen, Michael, Rufer, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833194/
https://www.ncbi.nlm.nih.gov/pubmed/31690351
http://dx.doi.org/10.1186/s40425-019-0773-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833194/
https://www.ncbi.nlm.nih.gov/pubmed/31690351
http://dx.doi.org/10.1186/s40425-019-0773-z

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