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Abnormal expression and clinical significance of 25-hydroxyvitamin D and sFlt-1 in patients with preeclampsia

OBJECTIVE: To determine the association between levels of serum 25-hydroxyvitamin D (25[OH]D) and soluble fms-like tyrosine kinase 1 (sFlt-1) in patients with preeclampsia. METHODS: Clinical and demographic data were collected from patients with preeclampsia and healthy pregnant controls. Serum 25(O...

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Autores principales: Chen, Xinhua, Xi, Xuxia, Cui, Fan, Wen, Ming, Hong, Aijuan, Hu, Zemei, Ni, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833401/
https://www.ncbi.nlm.nih.gov/pubmed/31510832
http://dx.doi.org/10.1177/0300060519860979
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author Chen, Xinhua
Xi, Xuxia
Cui, Fan
Wen, Ming
Hong, Aijuan
Hu, Zemei
Ni, Juan
author_facet Chen, Xinhua
Xi, Xuxia
Cui, Fan
Wen, Ming
Hong, Aijuan
Hu, Zemei
Ni, Juan
author_sort Chen, Xinhua
collection PubMed
description OBJECTIVE: To determine the association between levels of serum 25-hydroxyvitamin D (25[OH]D) and soluble fms-like tyrosine kinase 1 (sFlt-1) in patients with preeclampsia. METHODS: Clinical and demographic data were collected from patients with preeclampsia and healthy pregnant controls. Serum 25(OH)D and sFlt-1 levels were evaluated by enzyme-linked immunosorbent assay and their correlations were determined using Spearman’s rank correlation coefficient. Associations between serum 25(OH)D and sFlt-1 levels and disease severity and clinical parameters were evaluated. RESULTS: Significantly lower serum 25(OH)D and higher sFlt-1 levels were observed in patients with preeclampsia (n = 100) versus controls (n = 100), and 25(OH)D was inversely correlated with sFlt-1 in patients with preeclampsia. Serum 25(OH)D levels were reduced, while sFlt-1 concentration was increased in patients with severe versus mild preeclampsia. Serum 25(OH)D levels were reduced in late-onset versus early-onset severe preeclampsia. Patients with preeclampsia who had lower serum 25(OH)D or elevated sFlt-1 levels showed significantly higher blood pressure indexes versus those with higher 25(OH)D or lower sFlt-1. CONCLUSIONS: Low serum 25(OH)D and high sFlt-1 may be candidate biomarkers for preeclampsia diagnosis and prognosis.
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spelling pubmed-68334012019-11-13 Abnormal expression and clinical significance of 25-hydroxyvitamin D and sFlt-1 in patients with preeclampsia Chen, Xinhua Xi, Xuxia Cui, Fan Wen, Ming Hong, Aijuan Hu, Zemei Ni, Juan J Int Med Res Clinical Research Reports OBJECTIVE: To determine the association between levels of serum 25-hydroxyvitamin D (25[OH]D) and soluble fms-like tyrosine kinase 1 (sFlt-1) in patients with preeclampsia. METHODS: Clinical and demographic data were collected from patients with preeclampsia and healthy pregnant controls. Serum 25(OH)D and sFlt-1 levels were evaluated by enzyme-linked immunosorbent assay and their correlations were determined using Spearman’s rank correlation coefficient. Associations between serum 25(OH)D and sFlt-1 levels and disease severity and clinical parameters were evaluated. RESULTS: Significantly lower serum 25(OH)D and higher sFlt-1 levels were observed in patients with preeclampsia (n = 100) versus controls (n = 100), and 25(OH)D was inversely correlated with sFlt-1 in patients with preeclampsia. Serum 25(OH)D levels were reduced, while sFlt-1 concentration was increased in patients with severe versus mild preeclampsia. Serum 25(OH)D levels were reduced in late-onset versus early-onset severe preeclampsia. Patients with preeclampsia who had lower serum 25(OH)D or elevated sFlt-1 levels showed significantly higher blood pressure indexes versus those with higher 25(OH)D or lower sFlt-1. CONCLUSIONS: Low serum 25(OH)D and high sFlt-1 may be candidate biomarkers for preeclampsia diagnosis and prognosis. SAGE Publications 2019-09-12 2019-10 /pmc/articles/PMC6833401/ /pubmed/31510832 http://dx.doi.org/10.1177/0300060519860979 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Clinical Research Reports
Chen, Xinhua
Xi, Xuxia
Cui, Fan
Wen, Ming
Hong, Aijuan
Hu, Zemei
Ni, Juan
Abnormal expression and clinical significance of 25-hydroxyvitamin D and sFlt-1 in patients with preeclampsia
title Abnormal expression and clinical significance of 25-hydroxyvitamin D and sFlt-1 in patients with preeclampsia
title_full Abnormal expression and clinical significance of 25-hydroxyvitamin D and sFlt-1 in patients with preeclampsia
title_fullStr Abnormal expression and clinical significance of 25-hydroxyvitamin D and sFlt-1 in patients with preeclampsia
title_full_unstemmed Abnormal expression and clinical significance of 25-hydroxyvitamin D and sFlt-1 in patients with preeclampsia
title_short Abnormal expression and clinical significance of 25-hydroxyvitamin D and sFlt-1 in patients with preeclampsia
title_sort abnormal expression and clinical significance of 25-hydroxyvitamin d and sflt-1 in patients with preeclampsia
topic Clinical Research Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833401/
https://www.ncbi.nlm.nih.gov/pubmed/31510832
http://dx.doi.org/10.1177/0300060519860979
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