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Prenatal cold exposure causes hypertension in offspring by hyperactivity of the sympathetic nervous system

Environmental temperature plays a role in the variation of blood pressure. Maternal cold stress could affect the physiological phenotype of the offspring, including blood pressure elevation. In the present study, we found that adult offspring of dams exposed to cold have increased systolic and diast...

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Autores principales: Chen, Ken, Sun, Dongdong, Qu, Shuang, Chen, Yue, Wang, Jialiang, Zhou, Lin, Jose, Pedro A., Yang, Yongjian, Zeng, Chunyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833955/
https://www.ncbi.nlm.nih.gov/pubmed/31015358
http://dx.doi.org/10.1042/CS20190254
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author Chen, Ken
Sun, Dongdong
Qu, Shuang
Chen, Yue
Wang, Jialiang
Zhou, Lin
Jose, Pedro A.
Yang, Yongjian
Zeng, Chunyu
author_facet Chen, Ken
Sun, Dongdong
Qu, Shuang
Chen, Yue
Wang, Jialiang
Zhou, Lin
Jose, Pedro A.
Yang, Yongjian
Zeng, Chunyu
author_sort Chen, Ken
collection PubMed
description Environmental temperature plays a role in the variation of blood pressure. Maternal cold stress could affect the physiological phenotype of the offspring, including blood pressure elevation. In the present study, we found that adult offspring of dams exposed to cold have increased systolic and diastolic blood pressure, and decreased urine volume and sodium excretion, accompanied by increased heart rate and heart rate variability, secondary to increased activity of the sympathetic nervous system. Renal denervation or adrenergic receptor blockade decreased blood pressure and increased sodium excretion. The increase in peripheral sympathetic nerve activity can be ascribed to the central nervous system because administration of clonidine, a centrally acting α(2) adrenergic receptor agonist, lowered blood pressure to a greater degree in the prenatal cold-exposed than control offspring. Moreover, these prenatal cold-exposed offspring had hypothalamic paraventricular nucleus (PVN) disorder because magnetic resonance spectroscopy showed decreased N-acetylaspartate and increased choline and creatine ratios in the PVN. Additional studies found that prenatal cold exposure impaired the balance between inhibitory and excitatory neurons. This led to PVN overactivation that was related to enhanced PVN-angiotensin II type 1 (AT(1)) receptor expression and function. Microinjection of the AT(1) receptor antagonist losartan in the PVN lowered blood pressure to a greater extent in prenatal cold-exposed that control offspring. The present study provides evidence for overactive peripheral and central sympathetic nervous systems in the pathogenesis of prenatal cold-induced hypertension. Central AT(1) receptor blockade in the PVN may be a key step for treatment of this type hypertension.
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spelling pubmed-68339552019-11-06 Prenatal cold exposure causes hypertension in offspring by hyperactivity of the sympathetic nervous system Chen, Ken Sun, Dongdong Qu, Shuang Chen, Yue Wang, Jialiang Zhou, Lin Jose, Pedro A. Yang, Yongjian Zeng, Chunyu Clin Sci (Lond) Article Environmental temperature plays a role in the variation of blood pressure. Maternal cold stress could affect the physiological phenotype of the offspring, including blood pressure elevation. In the present study, we found that adult offspring of dams exposed to cold have increased systolic and diastolic blood pressure, and decreased urine volume and sodium excretion, accompanied by increased heart rate and heart rate variability, secondary to increased activity of the sympathetic nervous system. Renal denervation or adrenergic receptor blockade decreased blood pressure and increased sodium excretion. The increase in peripheral sympathetic nerve activity can be ascribed to the central nervous system because administration of clonidine, a centrally acting α(2) adrenergic receptor agonist, lowered blood pressure to a greater degree in the prenatal cold-exposed than control offspring. Moreover, these prenatal cold-exposed offspring had hypothalamic paraventricular nucleus (PVN) disorder because magnetic resonance spectroscopy showed decreased N-acetylaspartate and increased choline and creatine ratios in the PVN. Additional studies found that prenatal cold exposure impaired the balance between inhibitory and excitatory neurons. This led to PVN overactivation that was related to enhanced PVN-angiotensin II type 1 (AT(1)) receptor expression and function. Microinjection of the AT(1) receptor antagonist losartan in the PVN lowered blood pressure to a greater extent in prenatal cold-exposed that control offspring. The present study provides evidence for overactive peripheral and central sympathetic nervous systems in the pathogenesis of prenatal cold-induced hypertension. Central AT(1) receptor blockade in the PVN may be a key step for treatment of this type hypertension. 2019-05-09 2019-05-31 /pmc/articles/PMC6833955/ /pubmed/31015358 http://dx.doi.org/10.1042/CS20190254 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND).
spellingShingle Article
Chen, Ken
Sun, Dongdong
Qu, Shuang
Chen, Yue
Wang, Jialiang
Zhou, Lin
Jose, Pedro A.
Yang, Yongjian
Zeng, Chunyu
Prenatal cold exposure causes hypertension in offspring by hyperactivity of the sympathetic nervous system
title Prenatal cold exposure causes hypertension in offspring by hyperactivity of the sympathetic nervous system
title_full Prenatal cold exposure causes hypertension in offspring by hyperactivity of the sympathetic nervous system
title_fullStr Prenatal cold exposure causes hypertension in offspring by hyperactivity of the sympathetic nervous system
title_full_unstemmed Prenatal cold exposure causes hypertension in offspring by hyperactivity of the sympathetic nervous system
title_short Prenatal cold exposure causes hypertension in offspring by hyperactivity of the sympathetic nervous system
title_sort prenatal cold exposure causes hypertension in offspring by hyperactivity of the sympathetic nervous system
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833955/
https://www.ncbi.nlm.nih.gov/pubmed/31015358
http://dx.doi.org/10.1042/CS20190254
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