Cargando…

Mixed-Generation PAMAM G3-G0 Megamer as a Drug Delivery System for Nimesulide: Antitumor Activity of the Conjugate Against Human Squamous Carcinoma and Glioblastoma Cells

Polyhydroxylated dendrimer was synthesized from poly(amidoamine) (PAMAM) dendrimer generation 3 by addition of glycidol (G3(gl)). G3(gl) megamer was further modified by binding PAMAM G0 dendrimers by activation of G3(gl) with p-nitrophenylchloroformate, followed by the addition of excess PAMAM G0 an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zaręba, Magdalena, Sareło, Przemysław, Kopaczyńska, Marta, Białońska, Agata, Uram, Łukasz, Walczak, Małgorzata, Aebisher, David, Wołowiec, Stanisław
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834146/ https://www.ncbi.nlm.nih.gov/pubmed/31601050 http://dx.doi.org/10.3390/ijms20204998

Ejemplares similares

Synthesis and Different Effects of Biotinylated PAMAM G3 Dendrimer Substituted with Nimesulide in Human Normal Fibroblasts and Squamous Carcinoma Cells
por: Uram, Łukasz, et al.
Publicado: (2019)

Exploring the Potential of Lapatinib, Fulvestrant, and Paclitaxel Conjugated with Glycidylated PAMAM G4 Dendrimers for Cancer and Parasite Treatment
por: Uram, Łukasz, et al.
Publicado: (2023)

In vitro cytotoxicity of the ternary PAMAM G3–pyridoxal–biotin bioconjugate
por: Uram, Łukasz, et al.
Publicado: (2013)

Different patterns of nuclear and mitochondrial penetration by the G3 PAMAM dendrimer and its biotin–pyridoxal bioconjugate BC-PAMAM in normal and cancer cells in vitro
por: Uram, Łukasz, et al.
Publicado: (2015)

Biotin Transport-Targeting Polysaccharide-Modified PAMAM G3 Dendrimer as System Delivering α-Mangostin into Cancer Cells and C. elegans Worms
por: Markowicz, Joanna, et al.
Publicado: (2021)

Synthesis of Biotinylated PAMAM G3 Dendrimers Substituted with R-Glycidol and Celecoxib/Simvastatin as Repurposed Drugs and Evaluation of Their Increased Additive Cytotoxicity for Cancer Cell Lines
por: Wróbel, Konrad, et al.
Publicado: (2022)

The Effect of Biotinylated PAMAM G3 Dendrimers Conjugated with COX-2 Inhibitor (celecoxib) and PPARγ Agonist (Fmoc-L-Leucine) on Human Normal Fibroblasts, Immortalized Keratinocytes and Glioma Cells in Vitro
por: Uram, Łukasz, et al.
Publicado: (2019)

Stepwise Glucoheptoamidation of Poly(Amidoamine) Dendrimer G3 to Tune Physicochemical Properties of the Potential Drug Carrier: In Vitro Tests for Cytisine Conjugates
por: Czerniecka-Kubicka, Anna, et al.
Publicado: (2020)

Synthesis and Properties of α-Mangostin and Vadimezan Conjugates with Glucoheptoamidated and Biotinylated 3rd Generation Poly(amidoamine) Dendrimer, and Conjugation Effect on Their Anticancer and Anti-Nematode Activities
por: Markowicz, Joanna, et al.
Publicado: (2022)

Selective cytotoxicity of PAMAM G5 core–PAMAM G2.5 shell tecto-dendrimers on melanoma cells
por: Schilrreff, Priscila, et al.
Publicado: (2012)

Palladium(0) Deposited on PAMAM Dendrimers as a Catalyst for C–C Cross Coupling Reactions
por: Borkowski, Tomasz, et al.
Publicado: (2011)

Bioconjugates of PAMAM dendrimers with trans-retinal, pyridoxal, and pyridoxal phosphate
por: Filipowicz, A, et al.
Publicado: (2012)

Nimesulide inhibits the proliferation of HepG2 by up-regulation of Smad4
por: Yang, Shaoqi, et al.
Publicado: (2012)

Molecular Mechanisms of Antitumor Activity of PAMAM Dendrimer Conjugates with Anticancer Drugs and a Monoclonal Antibody
por: Marcinkowska, Monika, et al.
Publicado: (2019)

MegaM@Rt2 EU Project: Open Source Tools for Mega-Modelling at Runtime of CPSs
por: Cruz, Jesus Gorroñogoitia, et al.
Publicado: (2020)

Polyethylene glycolated PAMAM dendrimers-Efavirenz conjugates
por: Pyreddy, Suneela, et al.
Publicado: (2014)

Antibody CD133 Biofunctionalization of Ammonium Acryloyldimethyltaurate and Vinylpyrrolidone Co-Polymer-Based Coating of the Vascular Implants
por: Sareło, Przemysław, et al.
Publicado: (2020)

In Vitro Evaluation of Third Generation PAMAM Dendrimer Conjugates
por: Najlah, Mohammad, et al.
Publicado: (2017)

Twenty Years of Research on Cyclodextrin Conjugates with PAMAM Dendrimers
por: Arima, Hidetoshi
Publicado: (2021)

Mechanism of Anticancer Action of Novel Imidazole Platinum(II) Complex Conjugated with G2 PAMAM-OH Dendrimer in Breast Cancer Cells
por: Czarnomysy, Robert, et al.
Publicado: (2021)

Chiral Recognition of Homochiral Poly (amidoamine) Dendrimers Substituted with R- and S-Glycidol by Keratinocyte (HaCaT) and Squamous Carcinoma (SCC-15) Cells In Vitro
por: Malinga-Drozd, Małgorzata, et al.
Publicado: (2021)

Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate
por: Svenningsen, Søren Wedel, et al.
Publicado: (2020)

Selectively Fluorinated PAMAM–Arginine Conjugates as Gene Delivery Vectors
por: Romani, Carola, et al.
Publicado: (2023)

Biotin-Containing Third Generation Glucoheptoamidated Polyamidoamine Dendrimer for 5-Aminolevulinic Acid Delivery System
por: Kaczorowska, Aleksandra, et al.
Publicado: (2021)

Optimization and In Vivo Toxicity Evaluation of G4.5 Pamam Dendrimer-Risperidone Complexes
por: Prieto, Maria Jimena, et al.
Publicado: (2014)

In vitro and in vivo uptake studies of PAMAM G4.5 dendrimers in breast cancer
por: Oddone, Natalia, et al.
Publicado: (2016)

Effect of Alkaline Conditions on Forming an Effective G4.0 PAMAM Complex with Doxorubicin
por: Szota, Magdalena, et al.
Publicado: (2023)

Photosensitizer and peptide-conjugated PAMAM dendrimer for targeted in vivo photodynamic therapy
por: Narsireddy, Amreddy, et al.
Publicado: (2015)

An Evaluation of CXCR4 Targeting with PAMAM Dendrimer Conjugates for Oncologic Applications
por: Lesniak, Wojciech G., et al.
Publicado: (2022)

DNA Condensation by Peptide-Conjugated PAMAM Dendrimers. Influence of Peptide Charge
por: Dannert, Corinna, et al.
Publicado: (2023)

Impact of Liposomal Drug Formulations on the RBCs Shape, Transmembrane Potential, and Mechanical Properties
por: Cyboran-Mikołajczyk, Sylwia, et al.
Publicado: (2021)

Antitumor activity of a folate receptor-targeted immunoglobulin G-doxorubicin conjugate
por: Yang, Tan, et al.
Publicado: (2017)

CTLA-4 affects expression of key cell cycle regulators of G0/G1 phase in neoplastic lymphocytes from patients with chronic lymphocytic leukaemia
por: Ciszak, Lidia, et al.
Publicado: (2015)

Recent Findings Concerning PAMAM Dendrimer Conjugates with Cyclodextrins as Carriers of DNA and RNA
por: Arima, Hidetoshi, et al.
Publicado: (2009)

Anticancer Activity of Water-Soluble Olsalazine-PAMAM-Dendrimer-Salicylic Acid-Conjugates
por: Cortez-Maya, Sandra, et al.
Publicado: (2019)

Molecular dynamics simulations in drug delivery research: Calcium chelation of G3.5 PAMAM dendrimers
por: Jones, David E., et al.
Publicado: (2016)

In silico and in vivo studies of gp120-HIV-derived peptides in complex with G4-PAMAM dendrimers
por: Rolando Alberto, Rodríguez-Fonseca, et al.
Publicado: (2020)

Synthesis, Internalization and Visualization of N-(4-Carbomethoxy) Pyrrolidone Terminated PAMAM [G5:G3-TREN] Tecto(dendrimers) in Mammalian Cells †
por: Studzian, Maciej, et al.
Publicado: (2020)

Effect of methotrexate conjugated PAMAM dendrimers on the viability of MES-SA uterine cancer cells
por: Khatri, Samreen, et al.
Publicado: (2014)

Systematically probing the bottom-up synthesis of AuPAMAM conjugates for enhanced transfection efficiency
por: Figueroa, Elizabeth R., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_24osuiik5n1e0hqi015k2761ra