PPARγ and Cognitive Performance

Recent findings have led to the discovery of many signaling pathways that link nuclear receptors with human conditions, including mental decline and neurodegenerative diseases. PPARγ agonists have been indicated as neuroprotective agents, supporting synaptic plasticity and neurite outgrowth. For the...

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Detalles Bibliográficos
Autores principales: d’Angelo, Michele, Castelli, Vanessa, Catanesi, Mariano, Antonosante, Andrea, Dominguez-Benot, Reyes, Ippoliti, Rodolfo, Benedetti, Elisabetta, Cimini, Annamaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834178/
https://www.ncbi.nlm.nih.gov/pubmed/31614739
http://dx.doi.org/10.3390/ijms20205068
Descripción
Sumario:Recent findings have led to the discovery of many signaling pathways that link nuclear receptors with human conditions, including mental decline and neurodegenerative diseases. PPARγ agonists have been indicated as neuroprotective agents, supporting synaptic plasticity and neurite outgrowth. For these reasons, many PPARγ ligands have been proposed for the improvement of cognitive performance in different pathological conditions. In this review, the research on this issue is extensively discussed.

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