PPARγ and Cognitive Performance

Recent findings have led to the discovery of many signaling pathways that link nuclear receptors with human conditions, including mental decline and neurodegenerative diseases. PPARγ agonists have been indicated as neuroprotective agents, supporting synaptic plasticity and neurite outgrowth. For the...

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Autores principales: d’Angelo, Michele, Castelli, Vanessa, Catanesi, Mariano, Antonosante, Andrea, Dominguez-Benot, Reyes, Ippoliti, Rodolfo, Benedetti, Elisabetta, Cimini, Annamaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834178/
https://www.ncbi.nlm.nih.gov/pubmed/31614739
http://dx.doi.org/10.3390/ijms20205068
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author d’Angelo, Michele
Castelli, Vanessa
Catanesi, Mariano
Antonosante, Andrea
Dominguez-Benot, Reyes
Ippoliti, Rodolfo
Benedetti, Elisabetta
Cimini, Annamaria
author_facet d’Angelo, Michele
Castelli, Vanessa
Catanesi, Mariano
Antonosante, Andrea
Dominguez-Benot, Reyes
Ippoliti, Rodolfo
Benedetti, Elisabetta
Cimini, Annamaria
author_sort d’Angelo, Michele
collection PubMed
description Recent findings have led to the discovery of many signaling pathways that link nuclear receptors with human conditions, including mental decline and neurodegenerative diseases. PPARγ agonists have been indicated as neuroprotective agents, supporting synaptic plasticity and neurite outgrowth. For these reasons, many PPARγ ligands have been proposed for the improvement of cognitive performance in different pathological conditions. In this review, the research on this issue is extensively discussed.
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spelling pubmed-68341782019-11-25 PPARγ and Cognitive Performance d’Angelo, Michele Castelli, Vanessa Catanesi, Mariano Antonosante, Andrea Dominguez-Benot, Reyes Ippoliti, Rodolfo Benedetti, Elisabetta Cimini, Annamaria Int J Mol Sci Review Recent findings have led to the discovery of many signaling pathways that link nuclear receptors with human conditions, including mental decline and neurodegenerative diseases. PPARγ agonists have been indicated as neuroprotective agents, supporting synaptic plasticity and neurite outgrowth. For these reasons, many PPARγ ligands have been proposed for the improvement of cognitive performance in different pathological conditions. In this review, the research on this issue is extensively discussed. MDPI 2019-10-12 /pmc/articles/PMC6834178/ /pubmed/31614739 http://dx.doi.org/10.3390/ijms20205068 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
d’Angelo, Michele
Castelli, Vanessa
Catanesi, Mariano
Antonosante, Andrea
Dominguez-Benot, Reyes
Ippoliti, Rodolfo
Benedetti, Elisabetta
Cimini, Annamaria
PPARγ and Cognitive Performance
title PPARγ and Cognitive Performance
title_full PPARγ and Cognitive Performance
title_fullStr PPARγ and Cognitive Performance
title_full_unstemmed PPARγ and Cognitive Performance
title_short PPARγ and Cognitive Performance
title_sort pparγ and cognitive performance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834178/
https://www.ncbi.nlm.nih.gov/pubmed/31614739
http://dx.doi.org/10.3390/ijms20205068
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