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Autophagy, Metabolism, and Alcohol-Related Liver Disease: Novel Modulators and Functions
Alcohol-related liver disease (ALD) is caused by over-consumption of alcohol. ALD can develop a spectrum of pathological changes in the liver, including steatosis, inflammation, cirrhosis, and complications. Autophagy is critical to maintain liver homeostasis, but dysfunction of autophagy has been o...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834312/ https://www.ncbi.nlm.nih.gov/pubmed/31614437 http://dx.doi.org/10.3390/ijms20205029 |
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author | Yan, Shengmin Khambu, Bilon Hong, Honghai Liu, Gang Huda, Nazmul Yin, Xiao-Ming |
author_facet | Yan, Shengmin Khambu, Bilon Hong, Honghai Liu, Gang Huda, Nazmul Yin, Xiao-Ming |
author_sort | Yan, Shengmin |
collection | PubMed |
description | Alcohol-related liver disease (ALD) is caused by over-consumption of alcohol. ALD can develop a spectrum of pathological changes in the liver, including steatosis, inflammation, cirrhosis, and complications. Autophagy is critical to maintain liver homeostasis, but dysfunction of autophagy has been observed in ALD. Generally, autophagy is considered to protect the liver from alcohol-induced injury and steatosis. In this review, we will summarize novel modulators of autophagy in hepatic metabolism and ALD, including autophagy-mediating non-coding RNAs (ncRNAs), and crosstalk of autophagy machinery and nuclear factors. We will also discuss novel functions of autophagy in hepatocytes and non-parenchymal hepatic cells during the pathogenesis of ALD and other liver diseases. |
format | Online Article Text |
id | pubmed-6834312 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-68343122019-11-25 Autophagy, Metabolism, and Alcohol-Related Liver Disease: Novel Modulators and Functions Yan, Shengmin Khambu, Bilon Hong, Honghai Liu, Gang Huda, Nazmul Yin, Xiao-Ming Int J Mol Sci Review Alcohol-related liver disease (ALD) is caused by over-consumption of alcohol. ALD can develop a spectrum of pathological changes in the liver, including steatosis, inflammation, cirrhosis, and complications. Autophagy is critical to maintain liver homeostasis, but dysfunction of autophagy has been observed in ALD. Generally, autophagy is considered to protect the liver from alcohol-induced injury and steatosis. In this review, we will summarize novel modulators of autophagy in hepatic metabolism and ALD, including autophagy-mediating non-coding RNAs (ncRNAs), and crosstalk of autophagy machinery and nuclear factors. We will also discuss novel functions of autophagy in hepatocytes and non-parenchymal hepatic cells during the pathogenesis of ALD and other liver diseases. MDPI 2019-10-11 /pmc/articles/PMC6834312/ /pubmed/31614437 http://dx.doi.org/10.3390/ijms20205029 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Yan, Shengmin Khambu, Bilon Hong, Honghai Liu, Gang Huda, Nazmul Yin, Xiao-Ming Autophagy, Metabolism, and Alcohol-Related Liver Disease: Novel Modulators and Functions |
title | Autophagy, Metabolism, and Alcohol-Related Liver Disease: Novel Modulators and Functions |
title_full | Autophagy, Metabolism, and Alcohol-Related Liver Disease: Novel Modulators and Functions |
title_fullStr | Autophagy, Metabolism, and Alcohol-Related Liver Disease: Novel Modulators and Functions |
title_full_unstemmed | Autophagy, Metabolism, and Alcohol-Related Liver Disease: Novel Modulators and Functions |
title_short | Autophagy, Metabolism, and Alcohol-Related Liver Disease: Novel Modulators and Functions |
title_sort | autophagy, metabolism, and alcohol-related liver disease: novel modulators and functions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834312/ https://www.ncbi.nlm.nih.gov/pubmed/31614437 http://dx.doi.org/10.3390/ijms20205029 |
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