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Evidences from a Systematic Review and Meta-Analysis Unveil the Role of MiRNA Polymorphisms in the Predisposition to Female Neoplasms
Breast (BCa) and gynecological (GCa) cancers constitute a group of female neoplasms that has a worldwide significant contribution to cancer morbidity and mortality. Evidence suggests that polymorphisms influencing miRNA function can provide useful information towards predicting the risk of female ne...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834313/ https://www.ncbi.nlm.nih.gov/pubmed/31615040 http://dx.doi.org/10.3390/ijms20205088 |
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author | Bastami, Milad Choupani, Jalal Saadatian, Zahra Zununi Vahed, Sepideh Ouladsahebmadarek, Elaheh Mansoori, Yasser Daraei, Abdolreza Samadi Kafil, Hossein Yousefi, Bahman Mahdipour, Mahdi Masotti, Andrea Nariman-Saleh-Fam, Ziba |
author_facet | Bastami, Milad Choupani, Jalal Saadatian, Zahra Zununi Vahed, Sepideh Ouladsahebmadarek, Elaheh Mansoori, Yasser Daraei, Abdolreza Samadi Kafil, Hossein Yousefi, Bahman Mahdipour, Mahdi Masotti, Andrea Nariman-Saleh-Fam, Ziba |
author_sort | Bastami, Milad |
collection | PubMed |
description | Breast (BCa) and gynecological (GCa) cancers constitute a group of female neoplasms that has a worldwide significant contribution to cancer morbidity and mortality. Evidence suggests that polymorphisms influencing miRNA function can provide useful information towards predicting the risk of female neoplasms. Inconsistent findings in the literature should be detected and resolved to facilitate the genetic screening of miRNA polymorphisms, even during childhood or adolescence, and their use as predictors of future malignancies. This study represents a comprehensive systematic review and meta-analysis of the association between miRNA polymorphisms and the risk of female neoplasms. Meta-analysis was performed by pooling odds-ratios (ORs) and generalized ORs while using a random-effects model for 15 miRNA polymorphisms. The results suggest that miR-146a rs2910164 is implicated in the susceptibility to GCa. Moreover, miR-196a2 rs11614913-T had a moderate protective effect against female neoplasms, especially GCa, in Asians but not in Caucasians. MiR-27a rs895819-G might pose a protective effect against BCa among Caucasians. MiR-499 rs3746444-C may slightly increase the risk of female neoplasms, especially BCa. MiR-124 rs531564-G may be associated with a lower risk of female neoplasms. The current evidences do not support the association of the remaining polymorphisms and the risk of female neoplasms. |
format | Online Article Text |
id | pubmed-6834313 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-68343132019-11-25 Evidences from a Systematic Review and Meta-Analysis Unveil the Role of MiRNA Polymorphisms in the Predisposition to Female Neoplasms Bastami, Milad Choupani, Jalal Saadatian, Zahra Zununi Vahed, Sepideh Ouladsahebmadarek, Elaheh Mansoori, Yasser Daraei, Abdolreza Samadi Kafil, Hossein Yousefi, Bahman Mahdipour, Mahdi Masotti, Andrea Nariman-Saleh-Fam, Ziba Int J Mol Sci Review Breast (BCa) and gynecological (GCa) cancers constitute a group of female neoplasms that has a worldwide significant contribution to cancer morbidity and mortality. Evidence suggests that polymorphisms influencing miRNA function can provide useful information towards predicting the risk of female neoplasms. Inconsistent findings in the literature should be detected and resolved to facilitate the genetic screening of miRNA polymorphisms, even during childhood or adolescence, and their use as predictors of future malignancies. This study represents a comprehensive systematic review and meta-analysis of the association between miRNA polymorphisms and the risk of female neoplasms. Meta-analysis was performed by pooling odds-ratios (ORs) and generalized ORs while using a random-effects model for 15 miRNA polymorphisms. The results suggest that miR-146a rs2910164 is implicated in the susceptibility to GCa. Moreover, miR-196a2 rs11614913-T had a moderate protective effect against female neoplasms, especially GCa, in Asians but not in Caucasians. MiR-27a rs895819-G might pose a protective effect against BCa among Caucasians. MiR-499 rs3746444-C may slightly increase the risk of female neoplasms, especially BCa. MiR-124 rs531564-G may be associated with a lower risk of female neoplasms. The current evidences do not support the association of the remaining polymorphisms and the risk of female neoplasms. MDPI 2019-10-14 /pmc/articles/PMC6834313/ /pubmed/31615040 http://dx.doi.org/10.3390/ijms20205088 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bastami, Milad Choupani, Jalal Saadatian, Zahra Zununi Vahed, Sepideh Ouladsahebmadarek, Elaheh Mansoori, Yasser Daraei, Abdolreza Samadi Kafil, Hossein Yousefi, Bahman Mahdipour, Mahdi Masotti, Andrea Nariman-Saleh-Fam, Ziba Evidences from a Systematic Review and Meta-Analysis Unveil the Role of MiRNA Polymorphisms in the Predisposition to Female Neoplasms |
title | Evidences from a Systematic Review and Meta-Analysis Unveil the Role of MiRNA Polymorphisms in the Predisposition to Female Neoplasms |
title_full | Evidences from a Systematic Review and Meta-Analysis Unveil the Role of MiRNA Polymorphisms in the Predisposition to Female Neoplasms |
title_fullStr | Evidences from a Systematic Review and Meta-Analysis Unveil the Role of MiRNA Polymorphisms in the Predisposition to Female Neoplasms |
title_full_unstemmed | Evidences from a Systematic Review and Meta-Analysis Unveil the Role of MiRNA Polymorphisms in the Predisposition to Female Neoplasms |
title_short | Evidences from a Systematic Review and Meta-Analysis Unveil the Role of MiRNA Polymorphisms in the Predisposition to Female Neoplasms |
title_sort | evidences from a systematic review and meta-analysis unveil the role of mirna polymorphisms in the predisposition to female neoplasms |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834313/ https://www.ncbi.nlm.nih.gov/pubmed/31615040 http://dx.doi.org/10.3390/ijms20205088 |
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