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Evidences from a Systematic Review and Meta-Analysis Unveil the Role of MiRNA Polymorphisms in the Predisposition to Female Neoplasms

Breast (BCa) and gynecological (GCa) cancers constitute a group of female neoplasms that has a worldwide significant contribution to cancer morbidity and mortality. Evidence suggests that polymorphisms influencing miRNA function can provide useful information towards predicting the risk of female ne...

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Autores principales: Bastami, Milad, Choupani, Jalal, Saadatian, Zahra, Zununi Vahed, Sepideh, Ouladsahebmadarek, Elaheh, Mansoori, Yasser, Daraei, Abdolreza, Samadi Kafil, Hossein, Yousefi, Bahman, Mahdipour, Mahdi, Masotti, Andrea, Nariman-Saleh-Fam, Ziba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834313/
https://www.ncbi.nlm.nih.gov/pubmed/31615040
http://dx.doi.org/10.3390/ijms20205088
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author Bastami, Milad
Choupani, Jalal
Saadatian, Zahra
Zununi Vahed, Sepideh
Ouladsahebmadarek, Elaheh
Mansoori, Yasser
Daraei, Abdolreza
Samadi Kafil, Hossein
Yousefi, Bahman
Mahdipour, Mahdi
Masotti, Andrea
Nariman-Saleh-Fam, Ziba
author_facet Bastami, Milad
Choupani, Jalal
Saadatian, Zahra
Zununi Vahed, Sepideh
Ouladsahebmadarek, Elaheh
Mansoori, Yasser
Daraei, Abdolreza
Samadi Kafil, Hossein
Yousefi, Bahman
Mahdipour, Mahdi
Masotti, Andrea
Nariman-Saleh-Fam, Ziba
author_sort Bastami, Milad
collection PubMed
description Breast (BCa) and gynecological (GCa) cancers constitute a group of female neoplasms that has a worldwide significant contribution to cancer morbidity and mortality. Evidence suggests that polymorphisms influencing miRNA function can provide useful information towards predicting the risk of female neoplasms. Inconsistent findings in the literature should be detected and resolved to facilitate the genetic screening of miRNA polymorphisms, even during childhood or adolescence, and their use as predictors of future malignancies. This study represents a comprehensive systematic review and meta-analysis of the association between miRNA polymorphisms and the risk of female neoplasms. Meta-analysis was performed by pooling odds-ratios (ORs) and generalized ORs while using a random-effects model for 15 miRNA polymorphisms. The results suggest that miR-146a rs2910164 is implicated in the susceptibility to GCa. Moreover, miR-196a2 rs11614913-T had a moderate protective effect against female neoplasms, especially GCa, in Asians but not in Caucasians. MiR-27a rs895819-G might pose a protective effect against BCa among Caucasians. MiR-499 rs3746444-C may slightly increase the risk of female neoplasms, especially BCa. MiR-124 rs531564-G may be associated with a lower risk of female neoplasms. The current evidences do not support the association of the remaining polymorphisms and the risk of female neoplasms.
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spelling pubmed-68343132019-11-25 Evidences from a Systematic Review and Meta-Analysis Unveil the Role of MiRNA Polymorphisms in the Predisposition to Female Neoplasms Bastami, Milad Choupani, Jalal Saadatian, Zahra Zununi Vahed, Sepideh Ouladsahebmadarek, Elaheh Mansoori, Yasser Daraei, Abdolreza Samadi Kafil, Hossein Yousefi, Bahman Mahdipour, Mahdi Masotti, Andrea Nariman-Saleh-Fam, Ziba Int J Mol Sci Review Breast (BCa) and gynecological (GCa) cancers constitute a group of female neoplasms that has a worldwide significant contribution to cancer morbidity and mortality. Evidence suggests that polymorphisms influencing miRNA function can provide useful information towards predicting the risk of female neoplasms. Inconsistent findings in the literature should be detected and resolved to facilitate the genetic screening of miRNA polymorphisms, even during childhood or adolescence, and their use as predictors of future malignancies. This study represents a comprehensive systematic review and meta-analysis of the association between miRNA polymorphisms and the risk of female neoplasms. Meta-analysis was performed by pooling odds-ratios (ORs) and generalized ORs while using a random-effects model for 15 miRNA polymorphisms. The results suggest that miR-146a rs2910164 is implicated in the susceptibility to GCa. Moreover, miR-196a2 rs11614913-T had a moderate protective effect against female neoplasms, especially GCa, in Asians but not in Caucasians. MiR-27a rs895819-G might pose a protective effect against BCa among Caucasians. MiR-499 rs3746444-C may slightly increase the risk of female neoplasms, especially BCa. MiR-124 rs531564-G may be associated with a lower risk of female neoplasms. The current evidences do not support the association of the remaining polymorphisms and the risk of female neoplasms. MDPI 2019-10-14 /pmc/articles/PMC6834313/ /pubmed/31615040 http://dx.doi.org/10.3390/ijms20205088 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bastami, Milad
Choupani, Jalal
Saadatian, Zahra
Zununi Vahed, Sepideh
Ouladsahebmadarek, Elaheh
Mansoori, Yasser
Daraei, Abdolreza
Samadi Kafil, Hossein
Yousefi, Bahman
Mahdipour, Mahdi
Masotti, Andrea
Nariman-Saleh-Fam, Ziba
Evidences from a Systematic Review and Meta-Analysis Unveil the Role of MiRNA Polymorphisms in the Predisposition to Female Neoplasms
title Evidences from a Systematic Review and Meta-Analysis Unveil the Role of MiRNA Polymorphisms in the Predisposition to Female Neoplasms
title_full Evidences from a Systematic Review and Meta-Analysis Unveil the Role of MiRNA Polymorphisms in the Predisposition to Female Neoplasms
title_fullStr Evidences from a Systematic Review and Meta-Analysis Unveil the Role of MiRNA Polymorphisms in the Predisposition to Female Neoplasms
title_full_unstemmed Evidences from a Systematic Review and Meta-Analysis Unveil the Role of MiRNA Polymorphisms in the Predisposition to Female Neoplasms
title_short Evidences from a Systematic Review and Meta-Analysis Unveil the Role of MiRNA Polymorphisms in the Predisposition to Female Neoplasms
title_sort evidences from a systematic review and meta-analysis unveil the role of mirna polymorphisms in the predisposition to female neoplasms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834313/
https://www.ncbi.nlm.nih.gov/pubmed/31615040
http://dx.doi.org/10.3390/ijms20205088
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