Cargando…

Exploration and Development of PPAR Modulators in Health and Disease: An Update of Clinical Evidence

Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that govern the expression of genes responsible for energy metabolism, cellular development, and differentiation. Their crucial biological roles dictate the significance of PPAR-targeting synthetic ligands in medical research...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheng, Hong Sheng, Tan, Wei Ren, Low, Zun Siong, Marvalim, Charlie, Lee, Justin Yin Hao, Tan, Nguan Soon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834327/ https://www.ncbi.nlm.nih.gov/pubmed/31614690 http://dx.doi.org/10.3390/ijms20205055

Ejemplares similares

Kinomic profile in patient-derived glioma cells during hypoxia reveals c-MET-PI3K dependency for adaptation
por: Cheng, Hong Sheng, et al.
Publicado: (2021)

Utility of Human Relevant Preclinical Animal Models in Navigating NAFLD to MAFLD Paradigm
por: Chua, Damien, et al.
Publicado: (2022)

Insights into the Role of PPARβ/δ in NAFLD
por: Chen, Jiapeng, et al.
Publicado: (2018)

PPARs and Tumor Microenvironment: The Emerging Roles of the Metabolic Master Regulators in Tumor Stromal–Epithelial Crosstalk and Carcinogenesis
por: Cheng, Hong Sheng, et al.
Publicado: (2021)

Single-cell analysis of skin immune cells reveals an Angptl4-ifi20b axis that regulates monocyte differentiation during wound healing
por: Wee, Wei Kiat Jonathan, et al.
Publicado: (2022)

YWHAG Deficiency Disrupts the EMT‐Associated Network to Induce Oxidative Cell Death and Prevent Metastasis
por: Lee, Jeannie Xue Ting, et al.
Publicado: (2023)

Investigating the Role of PPARβ/δ in Retinal Vascular Remodeling Using Pparβ/δ-Deficient Mice
por: Ho, Sze Yuan, et al.
Publicado: (2020)

PPARβ/δ Agonism Upregulates Forkhead Box A2 to Reduce Inflammation in C2C12 Myoblasts and in Skeletal Muscle
por: Phua, Wendy Wen Ting, et al.
Publicado: (2020)

ROS release by PPARβ/δ-null fibroblasts reduces tumor load through epithelial antioxidant response
por: Tan, Eddie Han Pin, et al.
Publicado: (2018)

The Blood Microbiome and Health: Current Evidence, Controversies, and Challenges
por: Cheng, Hong Sheng, et al.
Publicado: (2023)

Regulation of epithelial–mesenchymal IL-1 signaling by PPARβ/δ is essential for skin homeostasis and wound healing
por: Chong, Han Chung, et al.
Publicado: (2009)

Impaired skin wound healing in peroxisome proliferator–activated receptor (PPAR)α and PPARβ mutant mice
por: Michalik, Liliane, et al.
Publicado: (2001)

Role of PPAR-related genes in chronic heart failure: evidence from large populations
por: Ke, Zun-Ping, et al.
Publicado: (2023)

Role of p53 in breast cancer progression: An insight into p53 targeted therapy
por: Marvalim, Charlie, et al.
Publicado: (2023)

Epithelial-mesenchymal transition of cancer cells using bioengineered hybrid scaffold composed of hydrogel/3D-fibrous framework
por: Pal, Mintu, et al.
Publicado: (2019)

Exploiting vulnerabilities of cancer by targeting nuclear receptors of stromal cells in tumor microenvironment
por: Cheng, Hong Sheng, et al.
Publicado: (2019)

Mobilization efficiency is critically regulated by fat via marrow PPARδ
por: Suzuki, Tomohide, et al.
Publicado: (2021)

Endothelial‐immune crosstalk contributes to vasculopathy in nonalcoholic fatty liver disease
por: Ng, Chun‐Yi, et al.
Publicado: (2022)

Characterisation of serum progesterone and progesterone-induced blocking factor (PIBF) levels across trimesters in healthy pregnant women
por: Lim, Mark Kit, et al.
Publicado: (2020)

PPARγ and PPARδ as Modulators of Neoplasia and Cell Fate
por: Glazer, Robert I., et al.
Publicado: (2008)

PPAR-α Modulators as Current and Potential Cancer Treatments
por: Tan, Yan, et al.
Publicado: (2021)

Selective deletion of PPARβ/δ in fibroblasts causes dermal fibrosis by attenuated LRG1 expression
por: Sng, Ming Keat, et al.
Publicado: (2018)

Reactive oxygen species: a volatile driver of field cancerization and metastasis
por: Liao, Zehuan, et al.
Publicado: (2019)

Microbial Dysregulation of the Gut-Lung Axis in Bronchiectasis
por: Narayana, Jayanth Kumar, et al.
Publicado: (2022)

Controlled-release nanoencapsulating microcapsules to combat inflammatory diseases
por: Baek, Jong-Suep, et al.
Publicado: (2017)

Targeting vascular leakage in lung inflammation
por: Li, Liang, et al.
Publicado: (2015)

Phytochemicals as Modulators of PPARs and RXRs
por: Ko, Joshua K., et al.
Publicado: (2010)

Matricellular Proteins: A Sticky Affair with Cancers
por: Chong, Han Chung, et al.
Publicado: (2012)

Update on Pparγ and Nonalcoholic Fatty Liver Disease
por: Ables, Gene P.
Publicado: (2012)

Membrane phospholipid alteration causes chronic ER stress through early degradation of homeostatic ER-resident proteins
por: Shyu, Peter, et al.
Publicado: (2019)

Pomegranate activates TFEB to promote autophagy-lysosomal fitness and mitophagy
por: Tan, Sijie, et al.
Publicado: (2019)

Evidence for a Higher Number of Species of Odontotermes (Isoptera) than Currently Known from Peninsular Malaysia from Mitochondrial DNA Phylogenies
por: Cheng, Shawn, et al.
Publicado: (2011)

Prostaglandins as PPARγ Modulators in Adipogenesis
por: Fujimori, Ko
Publicado: (2012)

The emerging role of Nrf2 in dermatotoxicology
por: Tan, Nguan S, et al.
Publicado: (2014)

Curcumin Protects Neuron against Cerebral Ischemia-Induced Inflammation through Improving PPAR-Gamma Function
por: Liu, Zun-Jing, et al.
Publicado: (2013)

Ligand Modulated Antagonism of PPARγ by Genomic and Non-Genomic Actions of PPARδ
por: Gustafsson, Mattias C. U., et al.
Publicado: (2009)

The Potential of the FSP1cre-Pparb/d(−/−) Mouse Model for Studying Juvenile NAFLD
por: Chen, Jiapeng, et al.
Publicado: (2019)

Conditional knock out of N-WASP in keratinocytes causes skin barrier defects and atopic dermatitis-like inflammation
por: Kalailingam, Pazhanichamy, et al.
Publicado: (2017)

Scaffold-Based Pan-Agonist Design for the PPARα, PPARβ and PPARγ Receptors
por: Zhang, Li-Song, et al.
Publicado: (2012)

Screening for PPAR Responsive Regulatory Modules in Cancer
por: Heinäniemi, Merja, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_93vtgd958ssbidd3po26uavoe9