The Predictive Role of the Biomarker Kidney Molecule-1 (KIM-1) in Acute Kidney Injury (AKI) Cisplatin-Induced Nephrotoxicity

Acute kidney injury (AKI) following platinum-based chemotherapeutics is a frequently reported serious side-effect. However, there are no approved biomarkers that can properly identify proximal tubular injury while routine assessments such as serum creatinine lack sensitivity. Kidney-injury-molecule...

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Detalles Bibliográficos
Autores principales: Tanase, Daniela Maria, Gosav, Evelina Maria, Radu, Smaranda, Costea, Claudia Florida, Ciocoiu, Manuela, Carauleanu, Alexandru, Lacatusu, Cristina Mihaela, Maranduca, Minela Aida, Floria, Mariana, Rezus, Ciprian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834366/
https://www.ncbi.nlm.nih.gov/pubmed/31652595
http://dx.doi.org/10.3390/ijms20205238
Descripción
Sumario:Acute kidney injury (AKI) following platinum-based chemotherapeutics is a frequently reported serious side-effect. However, there are no approved biomarkers that can properly identify proximal tubular injury while routine assessments such as serum creatinine lack sensitivity. Kidney-injury-molecule 1 (KIM-1) is showing promise in identifying cisplatin-induced renal injury both in vitro and in vivo studies. In this review, we focus on describing the mechanisms of renal tubular cells cisplatin-induced apoptosis, the associated inflammatory response and oxidative stress and the role of KIM-1 as a possible biomarker used to predict cisplatin associated AKI.

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