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The Predictive Role of the Biomarker Kidney Molecule-1 (KIM-1) in Acute Kidney Injury (AKI) Cisplatin-Induced Nephrotoxicity
Acute kidney injury (AKI) following platinum-based chemotherapeutics is a frequently reported serious side-effect. However, there are no approved biomarkers that can properly identify proximal tubular injury while routine assessments such as serum creatinine lack sensitivity. Kidney-injury-molecule...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834366/ https://www.ncbi.nlm.nih.gov/pubmed/31652595 http://dx.doi.org/10.3390/ijms20205238 |
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author | Tanase, Daniela Maria Gosav, Evelina Maria Radu, Smaranda Costea, Claudia Florida Ciocoiu, Manuela Carauleanu, Alexandru Lacatusu, Cristina Mihaela Maranduca, Minela Aida Floria, Mariana Rezus, Ciprian |
author_facet | Tanase, Daniela Maria Gosav, Evelina Maria Radu, Smaranda Costea, Claudia Florida Ciocoiu, Manuela Carauleanu, Alexandru Lacatusu, Cristina Mihaela Maranduca, Minela Aida Floria, Mariana Rezus, Ciprian |
author_sort | Tanase, Daniela Maria |
collection | PubMed |
description | Acute kidney injury (AKI) following platinum-based chemotherapeutics is a frequently reported serious side-effect. However, there are no approved biomarkers that can properly identify proximal tubular injury while routine assessments such as serum creatinine lack sensitivity. Kidney-injury-molecule 1 (KIM-1) is showing promise in identifying cisplatin-induced renal injury both in vitro and in vivo studies. In this review, we focus on describing the mechanisms of renal tubular cells cisplatin-induced apoptosis, the associated inflammatory response and oxidative stress and the role of KIM-1 as a possible biomarker used to predict cisplatin associated AKI. |
format | Online Article Text |
id | pubmed-6834366 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-68343662019-11-25 The Predictive Role of the Biomarker Kidney Molecule-1 (KIM-1) in Acute Kidney Injury (AKI) Cisplatin-Induced Nephrotoxicity Tanase, Daniela Maria Gosav, Evelina Maria Radu, Smaranda Costea, Claudia Florida Ciocoiu, Manuela Carauleanu, Alexandru Lacatusu, Cristina Mihaela Maranduca, Minela Aida Floria, Mariana Rezus, Ciprian Int J Mol Sci Review Acute kidney injury (AKI) following platinum-based chemotherapeutics is a frequently reported serious side-effect. However, there are no approved biomarkers that can properly identify proximal tubular injury while routine assessments such as serum creatinine lack sensitivity. Kidney-injury-molecule 1 (KIM-1) is showing promise in identifying cisplatin-induced renal injury both in vitro and in vivo studies. In this review, we focus on describing the mechanisms of renal tubular cells cisplatin-induced apoptosis, the associated inflammatory response and oxidative stress and the role of KIM-1 as a possible biomarker used to predict cisplatin associated AKI. MDPI 2019-10-22 /pmc/articles/PMC6834366/ /pubmed/31652595 http://dx.doi.org/10.3390/ijms20205238 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tanase, Daniela Maria Gosav, Evelina Maria Radu, Smaranda Costea, Claudia Florida Ciocoiu, Manuela Carauleanu, Alexandru Lacatusu, Cristina Mihaela Maranduca, Minela Aida Floria, Mariana Rezus, Ciprian The Predictive Role of the Biomarker Kidney Molecule-1 (KIM-1) in Acute Kidney Injury (AKI) Cisplatin-Induced Nephrotoxicity |
title | The Predictive Role of the Biomarker Kidney Molecule-1 (KIM-1) in Acute Kidney Injury (AKI) Cisplatin-Induced Nephrotoxicity |
title_full | The Predictive Role of the Biomarker Kidney Molecule-1 (KIM-1) in Acute Kidney Injury (AKI) Cisplatin-Induced Nephrotoxicity |
title_fullStr | The Predictive Role of the Biomarker Kidney Molecule-1 (KIM-1) in Acute Kidney Injury (AKI) Cisplatin-Induced Nephrotoxicity |
title_full_unstemmed | The Predictive Role of the Biomarker Kidney Molecule-1 (KIM-1) in Acute Kidney Injury (AKI) Cisplatin-Induced Nephrotoxicity |
title_short | The Predictive Role of the Biomarker Kidney Molecule-1 (KIM-1) in Acute Kidney Injury (AKI) Cisplatin-Induced Nephrotoxicity |
title_sort | predictive role of the biomarker kidney molecule-1 (kim-1) in acute kidney injury (aki) cisplatin-induced nephrotoxicity |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834366/ https://www.ncbi.nlm.nih.gov/pubmed/31652595 http://dx.doi.org/10.3390/ijms20205238 |
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