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Structure-based characterization of novel TRPV5 inhibitors

Transient receptor potential vanilloid 5 (TRPV5) is a highly calcium selective ion channel that acts as the rate-limiting step of calcium reabsorption in the kidney. The lack of potent, specific modulators of TRPV5 has limited the ability to probe the contribution of TRPV5 in disease phenotypes such...

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Detalles Bibliográficos
Autores principales:	Hughes, Taylor ET, Del Rosario, John Smith, Kapoor, Abhijeet, Yazici, Aysenur Torun, Yudin, Yevgen, Fluck, Edwin C, Filizola, Marta, Rohacs, Tibor, Moiseenkova-Bell, Vera Y
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Structural Biology and Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834369/ https://www.ncbi.nlm.nih.gov/pubmed/31647410 http://dx.doi.org/10.7554/eLife.49572

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