A case of Warthin-like papillary thyroid carcinoma with diffuse sclerosing stroma and a novel RET mutation: a new entity or a combined tumour?

Activating mutations of the RET gene have been described for both papillary (chromosomal rearrangement) and medullary (missense mutations) thyroid carcinomas. Here, we describe a case of a Warthin-like variant of papillary thyroid carcinoma displaying some morphological aspects that mimic the diffus...

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Detalles Bibliográficos
Autores principales: Maffini, Fausto, Lorenzini, Daniele, Lepanto, Daniela, De Fiori, Elvio, Fumagalli, Caterina, Rappa, Alessandra, Tagliabue, Marta, Barberis, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cancer Intelligence 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834387/
https://www.ncbi.nlm.nih.gov/pubmed/31921336
http://dx.doi.org/10.3332/ecancer.2019.965
Descripción
Sumario:Activating mutations of the RET gene have been described for both papillary (chromosomal rearrangement) and medullary (missense mutations) thyroid carcinomas. Here, we describe a case of a Warthin-like variant of papillary thyroid carcinoma displaying some morphological aspects that mimic the diffuse sclerosing variant. The tumour harboured BRAF V600E mutation and a novel germline point mutation in the RET gene, with unknown clinical and pathological meaning.

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