A case of Warthin-like papillary thyroid carcinoma with diffuse sclerosing stroma and a novel RET mutation: a new entity or a combined tumour?

Activating mutations of the RET gene have been described for both papillary (chromosomal rearrangement) and medullary (missense mutations) thyroid carcinomas. Here, we describe a case of a Warthin-like variant of papillary thyroid carcinoma displaying some morphological aspects that mimic the diffus...

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Autores principales: Maffini, Fausto, Lorenzini, Daniele, Lepanto, Daniela, De Fiori, Elvio, Fumagalli, Caterina, Rappa, Alessandra, Tagliabue, Marta, Barberis, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cancer Intelligence 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834387/
https://www.ncbi.nlm.nih.gov/pubmed/31921336
http://dx.doi.org/10.3332/ecancer.2019.965
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author Maffini, Fausto
Lorenzini, Daniele
Lepanto, Daniela
De Fiori, Elvio
Fumagalli, Caterina
Rappa, Alessandra
Tagliabue, Marta
Barberis, Massimo
author_facet Maffini, Fausto
Lorenzini, Daniele
Lepanto, Daniela
De Fiori, Elvio
Fumagalli, Caterina
Rappa, Alessandra
Tagliabue, Marta
Barberis, Massimo
author_sort Maffini, Fausto
collection PubMed
description Activating mutations of the RET gene have been described for both papillary (chromosomal rearrangement) and medullary (missense mutations) thyroid carcinomas. Here, we describe a case of a Warthin-like variant of papillary thyroid carcinoma displaying some morphological aspects that mimic the diffuse sclerosing variant. The tumour harboured BRAF V600E mutation and a novel germline point mutation in the RET gene, with unknown clinical and pathological meaning.
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spelling pubmed-68343872020-01-09 A case of Warthin-like papillary thyroid carcinoma with diffuse sclerosing stroma and a novel RET mutation: a new entity or a combined tumour? Maffini, Fausto Lorenzini, Daniele Lepanto, Daniela De Fiori, Elvio Fumagalli, Caterina Rappa, Alessandra Tagliabue, Marta Barberis, Massimo Ecancermedicalscience Case Report Activating mutations of the RET gene have been described for both papillary (chromosomal rearrangement) and medullary (missense mutations) thyroid carcinomas. Here, we describe a case of a Warthin-like variant of papillary thyroid carcinoma displaying some morphological aspects that mimic the diffuse sclerosing variant. The tumour harboured BRAF V600E mutation and a novel germline point mutation in the RET gene, with unknown clinical and pathological meaning. Cancer Intelligence 2019-10-02 /pmc/articles/PMC6834387/ /pubmed/31921336 http://dx.doi.org/10.3332/ecancer.2019.965 Text en © the authors; licensee ecancermedicalscience. http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Maffini, Fausto
Lorenzini, Daniele
Lepanto, Daniela
De Fiori, Elvio
Fumagalli, Caterina
Rappa, Alessandra
Tagliabue, Marta
Barberis, Massimo
A case of Warthin-like papillary thyroid carcinoma with diffuse sclerosing stroma and a novel RET mutation: a new entity or a combined tumour?
title A case of Warthin-like papillary thyroid carcinoma with diffuse sclerosing stroma and a novel RET mutation: a new entity or a combined tumour?
title_full A case of Warthin-like papillary thyroid carcinoma with diffuse sclerosing stroma and a novel RET mutation: a new entity or a combined tumour?
title_fullStr A case of Warthin-like papillary thyroid carcinoma with diffuse sclerosing stroma and a novel RET mutation: a new entity or a combined tumour?
title_full_unstemmed A case of Warthin-like papillary thyroid carcinoma with diffuse sclerosing stroma and a novel RET mutation: a new entity or a combined tumour?
title_short A case of Warthin-like papillary thyroid carcinoma with diffuse sclerosing stroma and a novel RET mutation: a new entity or a combined tumour?
title_sort case of warthin-like papillary thyroid carcinoma with diffuse sclerosing stroma and a novel ret mutation: a new entity or a combined tumour?
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834387/
https://www.ncbi.nlm.nih.gov/pubmed/31921336
http://dx.doi.org/10.3332/ecancer.2019.965
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