SCAN1-TDP1 trapping on mitochondrial DNA promotes mitochondrial dysfunction and mitophagy

A homozygous mutation of human tyrosyl-DNA phosphodiesterase 1 (TDP1) causes the neurodegenerative syndrome, spinocerebellar ataxia with axonal neuropathy (SCAN1). TDP1 hydrolyzes the phosphodiester bond between DNA 3′-end and a tyrosyl moiety within trapped topoisomerase I (Top1)-DNA covalent compl...

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Detalles Bibliográficos
Autores principales: Ghosh, Arijit, Bhattacharjee, Sangheeta, Chowdhuri, Srijita Paul, Mallick, Abhik, Rehman, Ishita, Basu, Sudipta, Das, Benu Brata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834389/
https://www.ncbi.nlm.nih.gov/pubmed/31723605
http://dx.doi.org/10.1126/sciadv.aax9778

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