Low-complexity domain of U1-70K modulates phase separation and aggregation through distinctive basic-acidic motifs

Liquid-liquid phase separation (LLPS) facilitates the formation of functional membraneless organelles and recent reports have linked this phenomenon to protein aggregation in neurodegenerative diseases. Understanding the mechanism of LLPS and its regulation thus promises to shed light on the pathoge...

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Detalles Bibliográficos
Autores principales: Xue, Song, Gong, Rui, He, Fanqi, Li, Yanqin, Wang, Yunjia, Tan, Tianwei, Luo, Shi-Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834393/
https://www.ncbi.nlm.nih.gov/pubmed/31723601
http://dx.doi.org/10.1126/sciadv.aax5349

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834393/
https://www.ncbi.nlm.nih.gov/pubmed/31723601
http://dx.doi.org/10.1126/sciadv.aax5349

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